All Publications
By Year
2026
Serum meprin α levels for the detection of systemic inflammatory response syndrome.
Beckinger S, Mengel M, Lindner M, Köhling V, Peters F, Götting I, Stoske J, Rusch J, Radke I, Schädler D, Bülck C, Bickenbach K, Rüffer M, Mailer RK, Schumacher N, Renné T, Haase M, Naumann R, Becker-Pauly C, Rüffer S. Mol Med. 2026 Jul 18;32(1):113. doi: 10.1186/s10020-026-01570-w.
The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets.
Kreiselmaier S, Keller M, Nardi L, Mueller C, von Wiegen N, Bickenbach K, Gröbner L, Abukhalaf M, Tholey A, Mueller MM, Körschgen H, Schmeisser MJ, Becker-Pauly C, Pietrzik CU. FASEB J. 2026 Jul 15;40(13):e72097. doi: 10.1096/fj.202601333R.
AURORA A interacts with DICER and SETD2 to promote S-phase progression.
Müller J, Daunke T, Berner N, Bhandare P, Gebhardt A, Hoffmann L, Diebold M, Vogt M, Hofstetter J, Cruz-Garcia Y, Dudvarski-Stankovic N, Schneider K, Adhikari B, Lamer S, Schlosser A, Büchel G, Sos ML, Küster B, Knapp S, Wilhelm S, Wolf E. EMBO Rep. 2026 Jun 30. doi: 10.1038/s44319-026-00850-0. Online ahead of print. PMID: 42380670
On the Scope of DCAF1-Recruiting PROTACs Degrading Protein Kinases.
Weckesser J, Miletić N, Sivashanmugam SA, Ohmayer U, Steger M, Shashikadze B, Gehrtz P, Unzue Lopez A, Wegener A, Dietz TY, Hammann T, Hartung IV, Elson L, Němec V, Schwalm MP, Adhikari B, Wolf E, Krämer A, Müller S, Daub H, Knapp S. J Med Chem. 2026 Jun 17. doi: 10.1021/acs.jmedchem.6c00383. Online ahead of print. PMID: 42304961
Zhang H, Guo Y, Adhikari B, Dudvarski-Stankovic N, Wolf E, Rudel T. Nat Commun. 2026 May 18;17(1):4420. doi: 10.1038/s41467-026-73213-x.
Klink N, Urban S, Seier JA, Adhikari B, Schwalm MP, Müller J, Dorsch M, Steinbach P, Jung J, Vogt M, Kaschani F, Koch J, Führer S, Kaiser M, Schulze N, Knapp S, Wolf E, Paschen A, Grüner BM, Gersch M. Nat Commun. 2026 May 13;17(1):4331. doi: 10.1038/s41467-026-72295-x.
Duhay V, Tian M, Kosieradzka K, Ebner M, Lo WT, Krauss M, Sprengel HL, Voss M, Riechmann M, Savas JN, Schwake M, Haucke V, Damme M. Nat Commun. 2026 Mar 14. doi: 10.1038/s41467-026-70345-y. Online ahead of print.
Klapproth E, Marks J, Diaba-Nuhoho P, Grell S, Leubauer P, Kämmerer S, Soltwedel JR, Rasmussen F, Mejia F, Moss ML, Prince C, Mirtschink P, Wielockx B, Saftig P, Wagner M, Lorenz K, El-Armouche A. Br J Pharmacol. 2026 Mar;183(5):990-1008. doi: 10.1111/bph.70201. Epub 2025 Oct 8.
Meprin β elevates hippocampal soluble Aβ in the APP/V717I mouse model.
Keller M, Gallagher C, Marengo L, Bickenbach K, Schmitt U, Abukhalaf M, Tholey A, Kreiselmaier S, Becker-Pauly C, Mittmann T, Pietrzik CU.Exp Neurol. 2026 Mar;397:115600. doi: 10.1016/j.expneurol.2025.115600. Epub 2025 Dec 19.
Köhling V, Peters F, Götting I, Fries E, Beck N, Armbrust F, Beckinger S, Bülck C, Canbay V, Harder I, Mengel M, Rüffer M, Bickenbach K, Kalogeropoulos K, Schweizer M, Lewerenz M, Schumacher N, Jonca N, Haase M, Naumann R, Auf dem Keller U, Becker-Pauly C, Rüffer S. J Invest Dermatol. 2026 Feb 10:S0022-202X(26)00084-9. doi: 10.1016/j.jid.2026.01.034. Online ahead of print.
Peng J, Yang J, Antonopoulou G, Fang R, Adhikari B, Vogt M, Wolf E, Sun C, Du S, Godfrey L, Gupta A, Trajkovic-Arsic M, Teichmann N, Grünwald BT, Krebs N, Steiger K, Mogler C, Althoff K, Wang X, Giglio G, Liffers ST, Savvatakis K, Braren R, Lawlor RT, Scarpa A, Behrens D, Lang KS, Cheung PF, Siveke JT. Nat Commun. 2026 Feb 6. doi: 10.1038/s41467-026-69013-y. Online ahead of print.
Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery.
Mitrović M, Greco FA, García YC, Lučić A, Hoffmann L, Chander R, Schönfeld J, Liebisch N, Sivashanmugam SA, Schwalm MP, Egner M, Lewandowski M, Merk D, Morasch V, Wolf E, Müller S, Hanke T, Proschak E, Hiesinger K, Knapp S. J Med Chem. 2026 Jan 23. doi: 10.1021/acs.jmedchem.5c02543. Online ahead of print. PMID: 41575171
O'Hanlon JA, Gutsche K, Müller JE, Ranjan Prusty N, Mirza A, Roumeliotis TI, Yang H, Stubbs M, Hallett ST, Eing L, McAndrew PC, Choudhary JS, Le Bihan YV, Caldwell J, van Montfort RLM, Workman P, Wolf E*, Newton GK*, Evans LE*
J Med Chem. 2026 Jan 12. doi: 10.1021/acs.jmedchem.5c03024. Online ahead of print.
Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease.
Lahme K, Sachs W, Froembling S, Loreth D, Böttcher-Dierks V, Neumann K, Hann FM, Arkan N, Brehler M, Reichelt J, Sgries A, Surmann K, Gaffling S, Adler MR, Sáez PJ, Wedekind U, Lampert A, Tasika E, Saftig P, Conze C, Thünauer R, Skuza S, Neitzel K, Zielinski S, Brand J, Bonn S, Michalik S, Völker U, Zimmermann M, Wiech T, Meyer TN, Fester L, Meyer-Schwesinger C. Cell. 2026 Jan 8;189(1):123-142.e30. doi: 10.1016/j.cell.2025.11.010. Epub 2025 Dec 4.
2025
LIMP-2 deficiency-associated glycolipid abnormalities in mice.
Gaspar P, Marques ARA, Ferraz MJ, Damme M, Kramer G, Mirzaian M, Gijbels M, Ottenhoff R, van Roomen C, Overkleeft HS, Schwake M, Heybrock S, Macário MC, Saftig P, Aerts JM. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Oct;1870(7):159657.
Roles of lysosomal small-molecule transporters in metabolism and signaling.
Damme M, Guelle O, Löw C, Gasnier B.Trends Cell Biol. 2025 Oct 17:S0962-8924(25)00222-3.
Type I interferon limits interleukin-6 signaling in SLE through shedding interleukin-6 receptors].
Hempel M, Klapproth E, Krause A, Becker-Pauly C, Zeissig S, Heschel B, Weser N, Fantana J, Leuchten N, Rose-John S, El-Armouche A, Korb-Pap A, Aringer M.Rheumatology (Oxford). 2025 Jul 9:keaf281. doi: 10.1093/rheumatology/keaf281.
Meprin β Modulates Brevican Proteolysis Impairing Neural Plasticity and Memory Formation.
Keller M, Gallagher C, Kreiselmaier S, Bickenbach K, Schmitt U, Marengo L, Taghikhah D, Abukhalaf M, Tholey A, Becker-Pauly C, Mittmann T, Pietrzik CU.FASEB J. 2025 May 31;39(10):e70616. doi: 10.1096/fj.202500017R.
Regulation of podocyte surface proteins by the enzyme A Disintegrin And Metalloproteinase 10 (ADAM10).
Rosenbaum D, Reichelt J, Gudaitis S, Kühne S, Zielinski S, Loreth D, Blume L, Brand J, Vitzthum H, Sachs W, Lampert A, Seipold L, Voss M, Meyer-Schwesinger C, Saftig P.
Kidney Int. 2025 May 6:S0085-2538(25)00344-8. Epub ahead of print.
Induced proximity to PML protects TDP-43 from aggregation via SUMO–ubiquitin networks.
Wagner K, Keiten-Schmitz J, Adhikari B, Patra U, Husnjak K, McNicoll F, Dormann D, Müller-McNicoll M, Tascher G, Wolf E, Müller S.
Nat Chem Biol. 2025 Apr 17. doi: 10.1038/s41589-025-01886-4. Epub ahead of print.
Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.
Škapik IP, Giacomelli C, Hahn S, Deinlein H, Gallant P, Diebold M, Biayna J, Hendricks A, Olimski L, Otto C, Kastner C, Wolf E, Schülein-Völk C, Maurus K, Rosenwald A, Schleussner N, Jackstadt RF, Schlegel N, Germer CT, Bushell M, Eilers M, Schmidt S, Wiegering A.
EMBO J. 2025 Apr;44(7):2075-2105.
HYTANE-Identified Latrophilin-3 Cleavage by Meprin β Leads to Loss of the Interaction Domains.
Armbrust F, Bickenbach K, Koudelka T, Joos C, Keller M, Tholey A, Pietrzik CU, Becker-Pauly C. J Proteome Res. 2025 Apr 4;24(4):1832-1844. doi: 10.1021/acs.jproteome.4c00912. Epub 2025 Mar 26.
Bi-allelic LAMP3 variants in childhood interstitial lung disease: a surfactant-related disease.
Louvrier C, Desroziers T, Soreze Y, Delgado Rodriguez M, Thomas L, Nau V, Dastot-Le Moal F, Bernstein JA, Cole FS, Damme M, Fischer A, Griese M, Hinds D, Keehan L, Milla C, Mohammad H, Rips J, Wambach JA, Wegner DJ, Amselem S, Legendre M, Giurgea I, Karabina SA, Breuer O, Coulomb l'Herminé A, Nathan N. EBioMedicine. 2025 Mar;113:105626.
Workflow for E3 Ligase Ligand Validation for PROTAC Development.
Miletić N, Weckesser J, Mosler T, Rathore R, Hoffmann ME, Gehrtz P, Schlesiger S, Hartung IV, Berner N, Wilhelm S, Müller J, Adhikari B, Němec V, Sivashanmugam SA, Elson L, Holzmann H, Schwalm MP, Hoffmann L, Abdul Azeez KR, Müller S, Kuster B, Wolf E, Đikić I, Knapp S., ACS Chem Biol. 2025 Feb 21;20(2):507-521.
Targeted approach to determine the impact of cancer-associated protease variants.
Bickenbach K, David N, Koudelka T, Joos C, Scharfenberg F, Rüffer M, Armbrust F, Georgiadis D, Beau F, Stahmer L, Rahn S, Tholey A, Pietrzik C, Becker-Pauly C.
Sci Adv. 2025 Feb 14;11(7):eadp5958.
Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription.
Bhandare P, Narain A, Hofstetter J, Rummel T, Wenzel J, Schülein-Völk C, Lamer S, Eilers U, Schlosser A, Eilers M, Erhard F, Wolf E.
Nucleic Acids Res. 2025 Feb 8;53(4):gkae1219.
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.
Snaebjornsson MT, Poeller P, Komkova D, Röhrig F, Schlicker L, Winkelkotte AM, Chaves-Filho AB, Al-Shami KM, Caballero CD, Koltsaki I, Vogel FCE, Frias-Soler RC, Rudalska R, Schwarz JD, Wolf E, Dauch D, Steuer R, Schulze A.
Nat Metab. 2025 Feb;7(2):348-366.
Physiological shedding and C-terminal proteolytic processing of TMEM106B.
Held S, Erck C, Kemppainen S, Bleibaum F, Giridhar NJ, Feederle R, Krenner C, Juopperi SP, Calliari A, Mentrup T, Schröder B, Dickson DW, Rauramaa T, Petrucelli L, Prudencio M, Hiltunen M, Lüningschrör P, Capell A, Damme M.
Cell Rep. 2025 Jan 28;44(1):115107.
Expanding the genetic landscape of Usher syndrome type IV caused by pathogenic ARSG variants.
Bauwens M, De Man V, Audo I, Balikova I, Zein WM, Smirnov V, Held S, Vermeer S, Loos E, Jacob J, Casteels I, Désir J, Depasse F, Van de Sompele S, Van Heetvelde M, De Bruyne M, Andrieu C, Condroyer C, Antonio A, Hufnagel R, Carvalho AL, Marques JP, Zeitz C, De Baere E, Damme M.
Clin Genet. 2025 Jan;107(1):44-55.
Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε.
Haag A, Němec V, Janovská P, Bartošíková J, Adhikari B, Müller J, Schwalm MP, Čada Š, Ohmayer U, Daub H, Kim Y, Born F, Wolf E, Bryja V, Knapp S.
J Med Chem. 2025 Jan 9;68(1):506-530.
Klapproth, E., Marks, J., Diaba-Nuhoho, P., Grell, S., Leubauer, P., Kämmerer, S., Soltwedel, J.R., Rasmussen, F., Meija, F., Moss, M., ; Prince, C., Mirtschink, P., Wielockx, B., Saftig, P., Wagner, M., Lorenz, K., El-Armouche , A. (2025)
Brit. J. Pharmacol., in press
Balta, D., Varghese, A., Huarcaya S.P., Di Spiezio, A., Marquez, A.R.A., Akdas, E.Y., Tabakaciliar, D., Drobny, A., Werner, C., Xiang, W., Mächtel, R., Dobert, J.P., Fejtova, A., Richter, F., Küspert, M., Arnold, P., Saftig, P., Zunke, F. (2025)
Mol. Neurodegen., 20, 95
LIMP-2 deficiency-associated glycolipid abnormalities in mice.
Gaspar, P., Marques, A.R.A., Ferraz, M.J., Damme, M., Kramer, G., Mirzaian, M., Gijbels, M., Ottenhof, R., vam Roomen, C., Overkleeft, H.S., Schwake, M., Heybrock, S., Macário, M.C., Saftig, P., Aerts, J.M. (2025)
Biochem. Biophys. Acta: Mol. Cell Biol. of Lipids, 1870, 159657
Regulation of Podocyte Surface Proteins by the A Disintegrin And Metalloproteinase 10 (ADAM10)
Rosenbaum, D., Reichelt, J., Gudaitis, S., Kühne,S., Zielinski, S., Loreth, D., Blume, L., Brand, J., Vitzthum, H., Sachs, W., Lampert, A., Seipold, L., Voss, M., Meyer-Schwesinger, C.*, Saftig, P.* (2025)
Kidney Int., 108, 214-232
Sphingosine-1-phosphate signaling activates E-Syt1 to facilitate HDL-derived cholesterol transport.
Xu, Z., Meng, Y., St-Germain, J., Afshari, A., Dixon, C.L., Heybrock, S., Zhao, Q., Weng, X., Chen,J., Collins,R., Hu, H., Zhou, Q., Sun,Q., Xu, P., Liu, W., Saftig, P., Raught. B., Fairn, G.D.,Neculai, D. (2025)
Nat. Cell Biol., 27, 918-930
Priego, N., de Pablos-Aragoneses, A., Perea-Garcia, M., Pieri, V., Hernandez-Oliver, C., Alvaro-Espinosa, L., Rojas, A., Sanchez, O., Steindl, A., Caleiras, E., Garcia, F., Gracia-martin, S., Grana-Castro, O., Carcia-Mulero, S., Serrano, D., Velasco-Beltran, P., Jimenez-Lasheras, B., Egia-Mendikute, L., Rupp, L., Stammberger, A., Meinhardt, M., Chaachou, A., Martinez-Saez, E., Bertero, L., Cassoni, P., Mangherini, L., Pellerino, A., Ruda, R., Soffietti, R., Al-Shahrour, F., Saftig, P., Sanz-Pamplona, R., Schmitz, M., Crocker, S.J., Calvo, A., Palazon, A., Renancer, A., Valiente, M. (2025)
Cancer Discov., 15:179-201
2024
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer.
Reissland M, Hartmann O, Tauch S, Bugter JM, Prieto-Garcia C, Schulte C, Loebbert S, Solvie D, Bitman-Lotan E, Narain A, Jacomin AC, Schuelein-Voelk C, Fuss CT, Pahor N, Ade C, Buck V, Potente M, Li V, Beliu G, Wiegering A, Grossmann T, Eilers M, Wolf E, Maric H, Rosenfeldt M, Maurice MM, Dikic I, Gallant P, Orian A, Diefenbacher ME.
Oncogene. 2024 Dec;43(50):3645-3659.
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway.
Brauer BK, Chen Z, Beirow F, Li J, Meisinger D, Capriotti E, Schweizer M, Wagner L, Wienberg J, Hobohm L, Blume L, Qiao W, Narimatsu Y, Carette JE, Clausen H, Winter D, Braulke T, Jabs S, Voss M.
EMBO J. 2024 Dec;43(24):6264-6290.
Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches.
Seubert AC, Krafft M, Bopp S, Helal M, Bhandare P, Wolf E, Alemany A, Riedel A, Kretzschmar K.
Stem Cell Reports. 2 2024 Dec 10;19(12):1706-1719.
Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA)
Adhikari B, Schneider K, Diebold M, Sotriffer C, Wolf E.
Elife. 2024 Dec 6;13:RP98450.
The lysosomal lipid transporter LIMP-2 is part of lysosome-ER STARD3-VAPB-dependent contact sites.
Rudnik S, Heybrock S, Coyaud E, Xu Z, Neculai D, Raught B, Oorschot V, Heus C, Klumperman J, Saftig P.
J Cell Sci. 2024 Nov 15;137(22):jcs261810.
Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases.
Sflakidou E, Adhikari B, Siokatas C, Wolf E*, Sarli V*.
ACS Pharmacol Transl Sci. 2024 Oct 19;7(11):3488-3501. *corresponding authors
Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy.
Hutchings AJ, Hambrecht B, Veh A, Giridhar NJ, Zare A, Angerer C, Ohnesorge T, Schenke M, Selvaraj BT, Chandran S, Sterneckert J, Petri S, Seeger B, Briese M, Stigloher C, Bischler T, Hermann A, Damme M, Sendtner M, Lüningschrör.
P. Nat Commun. 2024 Oct 4;15(1):8622.
Inhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high-level BACE1 expression.
Ulku I, Leung R, Herre F, Walther L, Shobo A, Saftig P, Hancock MA, Liebsch F, Multhaup G.
J Biol Chem. 2024 Aug;300(8):107510.
Non-canonical function of ADAM10 in presynaptic plasticity.
Bär J, Fanutza T, Reimann CC, Seipold L, Grohe M, Bolter JR, Delfs F, Bucher M, Gee CE, Schweizer M, Saftig P, Mikhaylova M.
Cell Mol Life Sci. 2024 Aug 9;81(1):342.
Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2.
Vogt M, Dudvarski Stankovic N, Cruz Garcia Y, Hofstetter J, Schneider K, Kuybu F, Hauck T, Adhikari B, Hamann A, Rocca Y, Grysczyk L, Martin B, Gebhardt-Wolf A, Wiegering A, Diefenbacher M, Gasteiger G, Knapp S, Saur D, Eilers M, Rosenfeldt M, Erhard F, Vos SM, Wolf E.
Gut. 2024 Aug 8;73(9):1509-1528.
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.
Song F, Kovac V, Mohammadi B, Littau JL, Scharfenberg F, Matamoros Angles A, Vanni I, Shafiq M, Orge L, Galliciotti G, Djakkani S, Linsenmeier L, Černilec M, Hartman K, Jung S, Tatzelt J, Neumann JE, Damme M, Tschirner SK, Lichtenthaler SF, Ricklefs FL, Sauvigny T, Schmitz M, Zerr I, Puig B, Tolosa E, Ferrer I, Magnus T, Rupnik MS, Sepulveda-Falla D, Matschke J, Šmid LM, Bresjanac M, Andreoletti O, Krasemann S, Foliaki ST, Nonno R, Becker-Pauly C, Monzo C, Crozet C, Haigh CL, Glatzel M, Curin Serbec V, Altmeppen HC.
Acta Neuropathol. 2024 Jul 9;148(1):2.
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes.
Jungnickel KEJ, Guelle O, Iguchi M, Dong W, Kotov V, Gabriel F, Debacker C, Dairou J, McCort-Tranchepain I, Laqtom NN, Chan SH, Ejima A, Sato K, Massa López D, Saftig P, Mehdipour AR, Abu-Remaileh M, Gasnier B, Löw C, Damme M.
Nat Cell Biol. 2024 Jul;26(7):1047-1061.
Proteolytic cleavage of Golgi glycosyltransferases by SPPL3 and other proteases and its implications for cellular glycosylation.
Voss M.
Biochim Biophys Acta Gen Subj. 2024 Jul;291(13):2733-2766.
Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown.
Daumke O, Damme M.
Structure. 2024 Jun 6;32(6):645-647.
Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis.
Gallwitz L, Bleibaum F, Voss M, Schweizer M, Spengler K, Winter D, Zöphel F, Müller S, Lichtenthaler S, Damme M, Saftig P.
Cell Mol Life Sci. 2024 May 22;81(1):227.
Correcting 4sU induced quantification bias in nucleotide conversion RNA-seq data.
Berg K, Lodha M, Delazer I, Bartosik K, Garcia YC, Hennig T, Wolf E, Dölken L, Lusser A, Prusty BK, Erhard F.
Nucleic Acids Res. 2024 Apr 24;52(7):e35.
Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells.
Zhuang X, Woods J, Ji Y, Scheich S, Mo F, Rajagopalan S, Coulibaly ZA, Voss M, Urlaub H, Staudt LM, Pan KT, Long EO.
Cell Rep. 2024 Apr 14;43(4):114105.
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts.
Trifault B, Mamontova V, Cossa G, Ganskih S, Wei Y, Hofstetter J, Bhandare P, Baluapuri A, Nieto B, Solvie D, Ade CP, Gallant P, Wolf E, Larsen DH, Munschauer M, Burger K.
Nucleic Acids Res. 2024 Apr 12;52(6):3050-3068.
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis.
Terron HM, Parikh SJ, Abdul-Hay SO, Sahara T, Kang D, Dickson DW, Saftig P, LaFerla FM, Lane S, Leissring MA.
Alzheimers Res Ther. 2024 Apr 4;16(1):70.
A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes.
Armbrust F, Bickenbach K, Altmeppen H, Foggetti A, Winkelmann A, Wulff P, Glatzel M, Pietrzik CU, Becker-Pauly C.
Cell Mol Life Sci. 2024 Mar 13;81(1):139.
Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Roske Y, Cappel C, Cremer N, Hoffmann P, Koudelka T, Tholey A, Heinemann U, Daumke O, Damme M.
Nucleic Acids Res. 2024 Jan 11;52(1):370-384.
2023
Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases.
Vadon- Le Goff S, Tessier A, Napoli M, Dieryckx C, Bauer J, Dussoyer M, Lagoutte P, Peyronnel C, Essayan L, Kleiser S, Tueni N, Bettler E, Mariano N, Errazuriz-Cerda E, Fruchart Gaillard C, Ruggiero F, Becker-Pauly C, Allain JM, Bruckner-Tuderman L, Nyström A, Moali C.
Nat Commun. 2023 Dec 4;14(1):8020.
Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila.
Hofstetter J, Ogunleye A, Kutschke A, Buchholz LM, Wolf E*, Raabe T*, Gallant P*.
Life Sci Alliance. 2023 Nov 7;7(1):e202302130. *corresponding authors
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages.
De Silva NS, Siewiera J, Alkhoury C, Nader GPF, Nadalin F, de Azevedo K, Couty M, Izquierdo HM, Bhargava A, Conrad C, Maurin M, Antoniadou K, Fouillade C, Londono-Vallejo A, Behrendt R, Bertotti K, Serdjebi C, Lanthiez F, Gallwitz L, Saftig P, Herrero-Fernández B, Saez A, González-Granado JM, van Niel G, Boissonnas A, Piel M, Manel N.
Nat Aging. 2023 Oct;3(10):1251-1268.
EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells
Schumacher N, Thomsen I, Brundert F, Hejret V, Düsterhöft S, Tichý B, Schmidt-Arras D, Voss M, Rose-John S.
Biochim Biophys Acta Mol Cell Res. 2023 October; 1870(7):119489.
Tetraspanin 15 Depletion impairs Extracellular Vesicle Docking with Target Neurons.
Stajano D, Lombino FL, Schweizer M, Glatzel M, Saftig P, Gromova KV, Kneussel M (2023)
J. Extracell. Biol. 2023 Sep 11;2(9):e113.
ADAM10-dependent Notch signaling establishes dental cell boundaries required for enamel formation.
Mitsiadis TA, Jimenez-Rojo L, Weber S, Saftig P, Pagella P. (2022)
iScience, 2022 Sep 16;25(10):105154.
The putative pleiotropic functions of meprin β in gastric cancer.
Siemsen W, Halske C, Behrens HM, Krüger S, Becker-Pauly C, Röcken C.
Gastric Cancer. 2023 Jul;26(4):542-552.
The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes.
Djakovic L, Henning T, Reinisch K, Milic A, Whisnant AW, Wolf K, Weiß E, Haas T, Grothey A, Jürgens CS, Kluge M, Wolf E, Erhard F, Friedel CC*, Dölken L*.
Nat Commun. 2023 Jul 31;14(1):4591. *corresponding authors
Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism.
Van Acker ZP, Perdok A, Hellemans R, North K, Vorsters I, Cappel C, Dehairs J, Swinnen JV, Sannerud R, Bretou M, Damme M, Annaert W.
Nat Commun. 2023 May 24;14(1):2847.
Rab GTPase regulation of phagosome-lysosome fusion is bypassed in the presence of micromolar Ca2.
Becker J, Schleinitz A, Hermsen C, Rappold S, Saftig P, Jeschke A, Haas A.
J Cell Sci. 2023 May 1;136(9):jcs260806.
Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein.
Mohammadi B, Song F, Matamoros-Angles A, Shafiq M, Damme M, Puig B, Glatzel M, Altmeppen HC.
Cell Tissue Res. 2023 Apr;392(1):215-234.
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Exp Cell Res. 2023 Apr 15;425(2):113541.
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis.
Bülck C, Nyström EEL, Koudelka T, Mannbar-Frahm M, Andresen G, Radhouani M, Tran F, Scharfenberg F, Schrell F, Armbrust F, Dahlke E, Zhao B, Vervaeke A, Theilig F, Rosenstiel P, Starkl P, Rosshart SP, Fickenscher H, Tholey A, Hansson GC, Becker-Pauly C.
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Multi Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins.
Akter F, Bonini S, Ponnaiyan S, Kögler-Mohrbacher B, Bleibaum F, Damme M, Renard BY, Winter D.
Mol Cell Proteomics. 2023 Mar;22(3):100509.
Lysosome-targeted multi-functional lipid probes reveal sterol transporters NPC1 and LIMP-2 as sphingosine transporters.
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Proteolysis of CD44 at the cell surface controls a downstream protease network.
Wöhner B, Li W, Hey S, Drobny A, Werny L, Becker-Pauly C, Lucius R, Zunke F, Linder S, Arnold P.
Front Mol Biosci. 2023 Feb 17;10:1026810.
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis.
Ulku I, Liebsch F, Akerman SC, Schulz JF, Kulic L, Hock C, Pietrzik C, di Spiezio A, Thinakaran G, Saftig P, Multhaup G. (2023)
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LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.
Rodrigues PM, Sousa LG, Perrod C, Maceiras AR, Ferreirinha P, Pombinho R, Romera-Cárdenas G, Gomez-Lazaro M, Senkara M, Pistolic J, Cabanes D, Klein L, Saftig P, Alves NL.
Autophagy. 2023 Feb;19(2):426-439.
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.
Schleinitz A, Pöttgen LA, Keren-Kaplan T, Pu J, Saftig P, Bonifacino JS, Haas A, Jeschke A.
Cell Rep. 2023 Jan 31;42(1):111969.
Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.
Cabron AS, Borgmeyer U, Richter J, Peisker H, Gutbrod K, Dörmann P, Capell A, Damme M.
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Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.
Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, Künzel SR, Kämmerer S, Günscht M, Sprott D, Lesche M, Rost F, Dahl A, Rauch E, Kattner L, Weber S, Mirtschink P, Kopaliani I, Guan K, Lorenz K, Saftig P, Wagner M, El-Armouche A.
Nat Commun. 2022 Dec 10;13(1):7648.
Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease.
Gallwitz L, Schmidt L, Marques ARA, Tholey A, Cassidy L, Ulku I, Multhaup G, Di Spiezio A, Saftig P.
Neurobiol Dis. 2022 Dec;175:105919.
MYC multimers shield stalled replication forks from RNA polymerase.
Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E*, Eilers M*.
Nature. 2022 Dec;612(7938):148-155. *corresponding authors
Zymogenic latency in an ∼250-million-year-old astacin metallopeptidase.
Guevara T, Rodríguez-Banqueri A, Stöcker W, Becker-Pauly C, Gomis-Rüth FX.
Acta Crystallogr D Struct Biol. 2022 Nov 1;78(Pt 11):1347-1357.
Usher syndrome type IV: clinically and molecularly confirmed by novel ARSG variants.
Velde HM, Reurink J, Held S, Li CHZ, Yzer S, Oostrik J, Weeda J, Haer-Wigman L, Yntema HG, Roosing S, Pauleikhoff L, Lange C, Whelan L, Dockery A, Zhu J, Keegan DJ, Farrar GJ, Kremer H, Lanting CP, Damme M, Pennings RJE.
Hum Genet. 2022 Nov;141(11):1723-1738.
Endogenous tagging reveals a mid-Golgi localization of the glycosyltransferase-cleaving intramembrane protease SPPL3
Truberg J, Hobohm L, Jochimsen A, Desel C, Schweizer M, Voss M.
Biochim Biophys Acta Mol Cell Res. 2022 Nov;1869(11):119345.
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals.
Pedram, K, Laqtom, NN, Shon, DJ, Di Spiezio A, Riley NM, Saftig P, Abu-Remaileh M, Bertozzi CR.
Proc. Natl. Acad. Sci. 2022 Sep 27;119(39):e2117105119.
The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis.
Schwarz JD, Lukassen S, Bhandare P, Eing L, Snaebjörnsson MT, García YC, Kisker JP, Schulze A, Wolf E.
Front Cell Dev Biol. 2022 Sep 14;10:954358.
RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells.
Otto C, Kastner C, Schmidt S, Uttinger K, Baluapuri A, Denk S, Rosenfeldt MT, Rosenwald A, Roehrig F, Ade CP, Schuelein-Voelk C, Diefenbacher ME, Germer CT, Wolf E, Eilers M, Wiegering A.
Mol Oncol. 2022 Aug;16(15):2788-2809.
Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc).
Schulte DM, Waetzig GH, Schuett H, Marx M, Schulte B, Garbers C, Lokau J, Vlacil AK, Schulz J, Seoudy AK, Schieffer B, Rosenstiel P, Seeger M, Laudes M, Rose-John S, Lützen U, Grote K, Schreiber S.
Front Pharmacol. 2022 Jun 9;13:758233.
The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo. Kirschke S, Ogunsulire I, Selvakumar B, Schumacher N, Sezin T, Rose-John S, Scheffold A, Garbers C, Lokau J.
J Biol Chem. 2022 Jun;298(6):101910.
Identification of IL-6 Signalling Components as Predictors of Severity and Outcome in COVID-19.
Rodríguez- Hernández MÁ, Carneros D, Núñez-Núñez M, Coca R, Baena R, López-Ruiz GM, Cano-Serrano ME, Martínez-Tellería A, Fuentes-López A, Praena-Fernandez JM, Garbers C, Hernández-Quero J, García F, Rose-John S, Bustos M.
Front Immunol. 2022 May 13;13:891456.
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Prieto Huarcaya S, Drobny A, Marques ARA, Di Spiezio A, Dobert JP, Balta D, Werner C, Rizo T, Gallwitz L, Bub S, Stojkovska I, Belur NR, Fogh J, Mazzulli JR, Xiang W, Fulzele A, Dejung M, Sauer M, Winner B, Rose-John S, Arnold P, Saftig P, Zunke F.
Autophagy. 2022 May;18(5):1127-1151.
Recombinant pro-Cathepsin D enhances alpha-Synuclein degradation in alpha-Synucleinopathy models.
Huarcaya SP, Drobny A, Marques ARA Di Spiezio A, Dobert JP, Balta D, Werner C, Rizo T, Gallwitz L, Bub S, Stojkovska I, Belur NR, Fogh J, Mazzulli JR, Xiang W, Fulzele A, Dejung M, Sauer M, Winner B, Rose-John S, Arnold P, Saftig P, Zunke F.
Autophagy, 2022 May;18(5):1127-1151.
BCAS3-Related Neurodevelopmental Disorder Shows Magnetic Resonance Imaging Features Resembling Brain Iron Accumulation.
Wong WK, Troedson C, Damme M, Goetti R, Temple SEL, Schöls L, Balousha G, Prelog K, Buckley M, Roscioli T, Hengel H, Mohammad SS.
Mov Disord. 2022 Apr;37(4):870-872
IL-6 Responsiveness of CD4+ and CD8+ T Cells after Allogeneic Stem Cell Transplantation Differs between Patients and Is Associated with Previous Acute Graft versus Host Disease and Pretransplant Antithymocyte Globulin Therapy.
Tvedt THA, Rose-John S, Tsykunova G, Ahmed AB, Gedde-Dahl T, Ersvær E, Bruserud Ø.
J Clin Med. 2022 Apr 30;11(9):2530.
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Mentrup T, Stumpff-Niggemann AY, Leinung N, Schlosser C, Schubert K, Wehner R, Tunger A, Schatz V, Neubert P, Gradtke AC, Wolf J, Rose-John S, Saftig P, Dalpke A, Jantsch J, Schmitz M, Fluhrer R, Jacobsen ID, Schröder B.
Nat Commun. 2022 Apr 6;13(1):1880.
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.
Mentrup T, Stumpff-Niggemann Y, Leinung N, Schlosser C, Schubert K, Wehner R, Tunger A, Schatz V, Neubert P, Gradtke AC, Wolf J, Rose-John S, Saftig P, Dalpke A, Jantsch J, Schmitz M, Fluhrer R, Jacobsen ID, Schröder B.
Nature Comm. 2022 Apr 6;13(1):1880
PCSK9 acts as a key regulator of Aβ clearance across the blood-brain barrier.
Mazura AD, Ohler A, Storck SE, Kurtyka M, Scharfenberg F, Weggen S, Becker-Pauly C, Pietrzik CU.
Cell Mol Life Sci. 2022 Mar 27;79(4):212.
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
Marengo L, Armbrust F, Schoenherr C, Storck SE, Schmitt U, Zampar S, Wirths O, Altmeppen H, Glatzel M, Kaether C, Weggen S, Becker-Pauly C, Pietrzik CU.
Cell Mol Life Sci. 2022 Mar 2;79(3):168.
Meprin and ADAM proteases as triggers of systemic inflammation in sepsis.
Rahn S, Becker-Pauly C.
FEBS Lett. 2022 Mar;596(5):534-556. Review.
Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing.
Png G, Gerlini R, Hatzikotoulas K, Barysenka A, Rayner NW, Klarić L, Rathkolb B, Aguilar-Pimentel JA, Rozman J, Fuchs H, Gailus-Durner V, Tsafantakis E, Karaleftheri M, Dedoussis G, Pietrzik C, Wilson JF, Angelis MH, Becker-Pauly C, Gilly A, Zeggini E.
Hum Mol Genet. 2022 Mar;596(5):534-556.
MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties.
Werny L, Grogro A, Bickenbach K, Bülck C, Armbrust F, Koudelka T, Pathak K, Scharfenberg F, Sammel M, Sheikhouny F, Tholey A, Linder S, Becker-Pauly C.
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Mechanisms of interorgan crosstalk in health and disease.
Herrlich A, Kefaloyianni E, Rose-John S.
FEBS Lett. 2022 Mar;596(5):529-533.
Intravitreal gene therapy restores the autophagy-lysosomal pathway and attenuates retinal degeneration in cathepsin D-deficient mice.
Liu J, Bassal M, Schlichting S, Braren I, Di Spiezio A, Saftig P, Bartsch U.
Neurobiol Dis. 2022 Mar;164:105628
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Rudnik S, Heybrock S, Saftig P, Damme M.
J Cell Sci. 2022 Mar 1;135(5)
N- terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion.
Hobohm L, Koudelka T, Bahr FH, Truberg J, Kapell S, Schacht SS, Meisinger D, Mengel M, Jochimsen A, Hofmann A, Heintz L, Tholey A, Voss M.
Cell Mol Life Sci. 2022 Mar 13;79(3):185
The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis.
Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE.
Front Oncol. 2022 Feb 8;12:777634
Enhancement of proliferation of human umbilical cord blood-derived CD34+ hematopoietic stem cells by a combination of hyper-interleukin-6 and small molecules.
Park YS, Lee Y, Choi NY, Hwang HS, Rose-John S, Zenke M, Ko K.
Biochem Biophys Rep. 2022 Jan 27;29:101214.
Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia.
Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, V Koningsbruggen-Rietschel S, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dötsch J, Alejandre Alcazar MA.
Eur Respir J. 2022 Feb 17;59(2):2002248.
IL-6- induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
Dudek M, Lohr K, Donakonda S, Baumann T, Lüdemann M, Hegenbarth S, Dübbel L, Eberhagen C, Michailidou S, Yassin A, Prinz M, Popper B, Rose-John S, Zischka H, Knolle PA.
Cell Rep. 2022 Feb 15;38(7):110389.
MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress.
Sipol A, Hameister E, Xue B, Hofstetter J, Barenboim M, Öllinger R, Jain G, Prexler C, Rubio RA, Baldauf MC, Franchina DG, Petry A, Schmäh J, Thiel U, Görlach A, Cario G, Brenner D, Richter GHS, Grünewald TGP, Rad R, Wolf E, Ruland J, Sorensen PH, Burdach SEG.
Blood. 2022 Feb 24;139(8):1184-1197.
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D.
J Exp Med. 2022 Jan 3;219(1):e20201039.
ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer.
Schumacher N, Rose-John S.
Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119141.
Lung emphysema and impaired macrophage elastase1 clearance in mucolipin 3 deficient mice.
Spix B, Butz ES, Chen CC, Scotto Rosato A, Tang R, Jeridi A, Kudrina V, Plesch E, Wartenberg P, Arlt E, Briukhovetska D, Ansari M, Günsel GG, Conlon TM, Wyatt A, Wetzel S, Teupser D, Holdt LM, Ectors F, Boekhoff I, Boehm U, García-Añoveros J, Saftig P, Giera M, Kobold S, Schiller HB, Zierler S, Gudermann T, Wahl-Schott C, Bracher F, Yildirim A, Biel M, Grimm, C.
Nat Commun. 2022 Jan 14;13(1):318
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht S, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D.
J. Exp. Med. 2022 Jan 3;219(1):e20201039
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D.
J Exp Med. 2022 Jan 3;219(1):e20201039
Novel, highly potent PROTACs targeting AURORA-A kinase.
Bozilovic J, Eing L, Berger BT, Adhikari B, Weckesser J, Berner NB, Wilhelm S, Kuster B, Wolf E*, Knapp S*.
Current Research in Chemical Biology 2:100032 *corresponding authors
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, den Dekker AT, Brouwer RWW, Baluapuri A, Habringer S, Reichert M, Illendula A, Krämer OH, Schick M, Wolf E, van IJcken WFJ, Esposito I, Keller U, Schneider G, Wirth M.
PNAS. 2022, 119(9).
Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma.
Riedel A, Helal M, Pedro L, Swietlik JJ, Shorthouse D, Schmitz W, Haas L, Young T, da Costa ASH, Davidson S, Bhandare P, Wolf E, Hall BA, Frezza C, Oskarsson T, Shields JD.
Cancer Immunol Res. 2022, 10(4):482-497.
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis andgenetic instability in diffuse large B-cell lymphoma
Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K,Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A,Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R,Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, OostendorpRAJ, Miething C, Lenhof HP, Bassermann F, Chapuy B, Wirth M, Wolf E, Rad R, Müller S, Keller U.
Nature Communications 13.
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.
Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M.
Mol Cell. 2022 Jan 6;82(1):159-176.e12.
2021
Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.
Grainger AT, Pilar N, Li J, Chen MH, Abramson AM, Becker-Pauly C, Shi W.
Genetics. 2021 Dec 10;219(4):iyab160.
Corrigendum to "Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis".
Peters F, Rahn S, Mengel M, Scharfenberg F, Otte A, Koudelka T, Wagner EF, Wunderlich FT, Haase M, Naumann R, Tholey A, Becker-Pauly C.
Matrix Biol. 2021 Nov 2:S0945-053X(21)00096-2.
AMPylation profiling during neuronal differentiation reveals extensive variation on lysosomal proteins.
Becker T, Cappel C, Di Matteo F, Sonsalla G, Kaminska E, Spada F, Cappello S, Damme M, Kielkowski P.
iScience. 2021 Nov 26;24(12):103521
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.
Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bär J, Shrivastava AN, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, Mazzola F, Varani L, Thapa S, Gilch S, Schätzl H, Harris DA, Triller A, Mikhaylova M, Aguzzi A, Altmeppen HC, Glatzel M.
Sci Adv. 2021 Nov 26;7(48)
Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells.
Fritsch J, Frankenheim J, Marischen L, Vadasz T, Troeger A, Rose-John S, Schmidt-Arras D, Schneider-Brachert W.
Cells. 2021 Nov 10;10(11):3100. 2021 Nov;18(11):787-803.
Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells.
Adhikari B*, Narain A, Wolf E*.
STAR Protoc. 2021 Nov 19;2(4):100949. *corresponding authors
The Swedish dilemma - the almost exclusive use of APPswe-based mouse models impedes adequate evaluation of alternative β-secretases.
Armbrust F, Bickenbach K, Marengo L, Pietrzik C, Becker-Pauly C.
Biochim Biophys Acta Mol Cell Res. 2021 Oct 23:119164.
Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R.
Gellrich A, Scharfenberg F, Peters F, Sammel M, Helm O, Armbrust F, Schmidt F, Lokau J, Garbers C, Sebens S, Arnold P, Becker-Pauly C.
Front Mol Biosci. 2021 Oct 6;8:702341.
Regulation of meprin metalloproteases in mucosal homeostasis.
Werny L, Colmorgen C, Becker-Pauly C.
Biochim Biophys Acta Mol Cell Res. 2021 Oct 6;1869(1):119158.
CLN6 deficiency causes selective changes in the lysosomal protein composition.
Tuermer A, Mausbach S, Kaade E, Damme M, Sylvester M, Gieselmann V, Thelen M.
Proteomics. 2021 Oct;21(19):e2100043.
Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring.
Breuer S, Kasper P, Vohlen C, Janoschek R, Hoffmann T, Appel S, Müller-Limberger E, Mesaros A, Rose-John S, Garbers C, Müller S, Lackmann JW, Mahabir E, Dötsch J, Hucklenbruch-Rother E, Bae-Gartz I.
Nutrients. 2021 Oct 23;13(11):3735.
Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.
Künzel SR, Hoffmann M, Weber S, Künzel K, Kämmerer S, Günscht M, Klapproth E, Rausch JSE, Sadek MS, Kolanowski T, Meyer-Roxlau S, Piorkowski C, Tugtekin SM, Rose-John S, Yin X, Mayr M, Kuhlmann JD, Wimberger P, Grützmann K, Herzog N, Küpper JH, O'Reilly M, Kabir SN, Sommerfeld LC, Guan K, Wielockx B, Fabritz L, Nattel S, Ravens U, Dobrev D, Wagner M, El-Armouche A.
Circ Res. 2021 Oct;129(8):804-820.
Identification of the factor XII contact activation site enables sensitive coagulation diagnostics.
Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jämsä A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer JR, Rose-John S, Butler LM, Salomon O, Stavrou EX, Renné T.
Nat Commun. 2021 Sep 22;12(1):5596.
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis.
Del Poggetto E, Ho IL, Balestrieri C, Yen EY, Zhang S, Citron F, Shah R, Corti D, Diaferia GR, Li CY, Loponte S, Carbone F, Hayakawa Y, Valenti G, Jiang S, Sapio L, Jiang H, Dey P, Gao S, Deem AK, Rose-John S, Yao W, Ying H, Rhim AD, Genovese G, Heffernan TP, Maitra A, Wang TC, Wang L, Draetta GF, Carugo A, Natoli G, Viale A.
Science. 2021 Sep 17;373(6561):eabj0486.
Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis.
Shriki A, Lanton T, Sonnenblick A, Levkovitch-Siany O, Eidelshtein D, Abramovitch R, Rosenberg N, Pappo O, Elgavish S, Nevo Y, Safadi R, Peled A, Rose-John S, Galun E, Axelrod JH.
Cancer Res. 2021 Sep 15;81(18):4766-4777.
Post-translational modification by ADAM10 shape myeloid antigen presenting cell homeostasis in the splenic marginal zone.
Diener N, Fontaine J-F, Klein M, Hieronymus T, Wanke F, Kurschus F, Ludwig A, Ware C, Saftig P, Bopp T, Clausen BE, Backer RA.
Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2111234118
Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis.
Peters F, Rahn S, Mengel M, Scharfenberg F, Otte A, Koudelka T, Wagner EF, Wunderlich FT, Haase M, Naumann R, Tholey A, Becker-Pauly C.
Matrix Biol. 2021 Aug;102:37-69.
Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG).
Kowalewski B, Lange H, Galle S, Dierks T, Lübke T, Damme M.
Biochem J. 2021 Aug 18:BCJ20210415.
Macrophage-derived IL-6 trans-signaling as a novel target in the pathogenesis of bronchopulmonary dysplasia.
Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, Koningsbruggen-Rietschel SV, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dötsch J, Alejandre Alcazar MA.
Eur Respir J. 2021 Aug 26:2002248.
Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination.
Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dölken L, Schlosser A, Erhard F*, Baluapuri A*, Wolf E*.
Molecular Cell, 2021 Aug 5;81(15):3110-3127.e14. *corresponding authors
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.
Dölle A, Adhikari B, Krämer A, Weckesser J, Berner N, Berger LM, Diebold M, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Gebel J, Löhr F, Dötsch V, Eilers M, Heinzlmeir S, Kuster B, Sotriffer C, Wolf E*, Knapp S.*
J Med Chem. 2021 Aug 12;64(15):10682-10710. *corresponding authors
MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma.
Krenz B, Gebhardt-Wolf A, Ade CP, Gaballa A, Roehrig F, Vendelova E, Baluapuri A, Eilers U, Gallant P, D'Artista L, Wiegering A, Gasteiger G, Rosenfeldt MT, Bauer S, Zender L, Wolf E, Eilers M. Cancer Res. 2021 Aug 15;81(16):4242-4256.
Phosphorylation of meprin β controls its cell surface abundance and subsequently diminishes ectodomain shedding.
Armbrust F, Bickenbach K, Koudelka T, Tholey A, Pietrzik C, Becker-Pauly C.
FASEB J. 2021 Jul;35(7):e21677.
LAMP3 deficiency affects surfactant homeostasis in mice.
Lunding LP, Krause D, Stichtenoth G, Stamme C, Lauterbach N, Hegermann J, Ochs M, Schuster B, Sedlacek R, Saftig P, Schwudke D, Wegmann M, Damme M.
PLoS Genet. 2021 Jun 23;17(6):e1009619.
Quantification and characterization of the 5'exonuclease activity of the lysosomal nuclease PLD3 by a novel cell-based assay.
Cappel C, Gonzalez AC, Damme M.
J Biol Chem. Jan-Jun 2021;296:100152
The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis.
Davies R, Williams J, Sime K, Jin HS, Thompson C, Jordan L, Lang D, Halcox JP, Ellins E, Jones GW, Jones SA, Rose-John S, Williams A, Choy E.
Rheumatology (Oxford). 2021 Jun 18;60(6):2852-2861.
Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance.
Reif A, Lam K, Weidler S, Lott M, Boos I, Lokau J, Bretscher C, Mönnich M, Perkams L, Schmälzlein M, Graf C, Fischer JP, Lechner C, Hallstein K, Becker S, Weyand M, Steegborn C, Schultheiss G, Rose-John S, Garbers C, Unverzagt C.
Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13380-13387.
Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease.
Schreiber S, Aden K, Bernardes JP, Conrad C, Tran F, Höper H, Volk V, Mishra N, Blase JI, Nikolaus S, Bethge J, Kühbacher T, Röcken C, Chen M, Cottingham I, Petri N, Rasmussen BB, Lokau J, Lenk L, Garbers C, Feuerhake F, Rose-John S, Waetzig GH, Rosenstiel P.
Gastroenterology. 2021 Jun;160(7):2354-2366.e11.
Interleukin-6 controls recycling and degradation, but not internalization of its receptors.
Flynn CM, Kespohl B, Daunke T, Garbers Y, Düsterhöft S, Rose-John S, Haybaeck J, Lokau J, Aparicio-Siegmund S, Garbers C.
J Biol Chem. 2021 Jan-Jun;296:100434.
LAMP3 deficiency affects surfactant homeostasis in mice.
Lunding LP, Krause D, Stichtenoth G, Stamme C, Lauterbach N, Hegermann J, Ochs M, Schuster B, Sedlacek R, Saftig P, Schwudke D, Wegmann M, Damme M.
Plos Genetics 2021 Jun 23;17(6):e1009619
GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin.
Mattila SO, Tuhkanen HE, Lackman JJ, Konzacka A, Morató X, Argerich J, Saftig P, Ciruela F, Petäjä-Repo UE.
FASEB J. 2021 Jun;35(6):e21654
ADAM10-mediated ectodomain shedding is an essential driver of podocyte damage.
Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch RL, Lichtenthaler S., Saftig P*, Meyer-Schwesinger C.*
J. Am. Soc. Nephrol. 2021 Jun 1;32(6):1389-1408 (* equal senior authorship and correspondence)
ADAM10 hyperactivation acts on Piccolo to deplete synaptic vesicle stores in Huntington's disease.
Cozzolino F, Vezzoli E, Cheroni C, Besusso D, Conforti P, Valenza M, Iacobucci I, Monaco V, Birolini G, Bombaci M, Falqui A, Saftig P, Rossi R, Monti M, Cattaneo E, Zuccato C.
Hum. Mol. Gen. 2021 Jun 17;30(13):1175-1187
Distinct contributions of meprins to skin regeneration after injury - Meprin α a physiological processer of pro-collagen VII.
Kruppa D, Peters F, Bornert O, Maler MD, Martin SF, Becker-Pauly C, Nyström A.
Matrix Biol Plus. 2021 May 13;11:100065.
Initiation of Pancreatic Cancer: The Interplay of Hyperglycemia and Macrophages Promotes the Acquisition of Malignancy-Associated Properties in Pancreatic Ductal Epithelial Cells.
Otto L, Rahn S, Daunke T, Walter F, Winter E, Möller JL, Rose-John S, Wesch D, Schäfer H, Sebens S.
Int J Mol Sci. 2021 May 11;22(10):5086.
Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP.
Cancer Res. 2021 Apr 1;81(7):1627-1632.
Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles.
Lückstädt W, Bub S, Koudelka T, Pavlenko E, Peters F, Somasundaram P, Becker-Pauly C, Lucius R, Zunke F, Arnold P.
Front Cell Dev Biol. 2021 Mar 2;9:622390.
S-Palmitoylation determines TMEM55B-dependent positioning of lysosomes.
Rudnik S, Heybrock S, Saftig P, Damme M.
2021 Mar 1;135(5):jcs258566
New clinical and molecular evidence linking mutations in ARSG to Usher syndrome type IV.
Peter VG, Quinodoz M, Sadio S, Held S, Rodrigues M, Soares M, Sousa AB, Coutinho Santos L, Damme M, Rivolta C.
Hum Mutat. 2021 Mar;42(3):261-271
Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction.
Stroobants S, D'Hooge R, Damme M.
Brain Pathol. 2021 Mar;31(2):223-238.
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate.
Mailer RK, Allende M, Heestermans M, Schweizer M, Deppermann C, Frye M, Pula G, Odeberg J, Gelderblom M, Rose-John S, Sickmann A, Blankenberg S, Huber TB, Kubisch C, Maas C, Gambaryan S, Firsov D, Stavrou EX, Butler LM, Renné T.
Blood. 2021 Mar 11;137(10):1392-1405.
Rapid and progressive loss of multiple retinal cell types in cathepsin D-deficient mice, an animal model of CLN10 disease.
Bassal M, Liu J, Jankowiak W, Saftig P, Bartsch U.
Cells. 2021 Mar 21;10(3):696.
Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease.
Hartmann O, Reissland M, Maier CR, Fischer T, Prieto-Garcia C, Baluapuri A, Schwarz J, Schmitz W, Garrido-Rodriguez M, Pahor N, Davies CC, Bassermann F, Orian A, Wolf E, Schulze A, Calzado MA, Rosenfeldt MT, Diefenbacher ME.
Front Cell Dev Biol. 2021 Mar 2;9:641618
Discovery and Optimization of Selective Inhibitors of Meprin α (Part II).
Wang C, Diez J, Park H, Spicer TP, Scampavia LD, Becker-Pauly C, Fields GB, Minond D, Bannister TD.
Pharmaceuticals (Basel). 2021 Feb 27;14(3):197.
Discovery and Optimization of Selective Inhibitors of Meprin α (Part I).
Hou S, Diez J, Wang C, Becker-Pauly C, Fields GB, Bannister T, Spicer TP, Scampavia LD, Minond D.
Pharmaceuticals (Basel). 2021 Feb 28;14(3):203.
Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice.
Westermann LM, Baranowsky A, Di Lorenzo G, Danyukova T, Soul J, Schwartz JM, Hendrickx G, Amling M, Rose-John S, Garbers C, Schinke T, Pohl S.
Sci Rep. 2021 Feb 11;11(1):3556.
Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19.
Garbers C, Rose-John S.
Lancet Rheumatol. 2021 Feb;3(2):e96-e97.
ADAM17 Deficiency Protects against Pulmonary Emphysema.
Saad MI, McLeod L, Hodges C, Vlahos R, Rose-John S, Ruwanpura S, Jenkins BJ.
Am J Respir Cell Mol Biol. 2021 Feb;64(2):183-195.
Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice.
Schumacher N, Yan K, Gandraß M, Müller M, Krisp C, Häsler R, Carambia A, Nofer JR, Bernardes JP, Khouja M, Thomsen I, Chalupsky K, Bolik J, Hölscher C, Wunderlich T, Herkel J, Rosenstiel P, Schramm C, Schlüter H, Renné T, Mittrücker HW, Rose-John S, Schmidt-Arras D.
J Hepatol. 2021 Feb;74(2):407-418.
Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.
Endres T, Solvie D, Heidelberger JB, Andrioletti V, Baluapuri A, Ade CP, Muhar M, Eilers U, Vos SM, Cramer P, Zuber J, Beli P, Popov N, Wolf E, Gallant P, Eilers M.
Mol Cell. 2021 Feb 18;81(4):830-844.e13.
Plant roots employ cell-layer-specific programs to respond to pathogenic and beneficial microbes.
Fröschel C, Komorek J, Attard A, Marsell A, Lopez-Arboleda WA, Le Berre J, Wolf E, Geldner N, Waller F, Korte A, Dröge-Laser W.
Cell Host Microbe. 2021 Feb 10;29(2):299-310.e7.
Meprin β: A novel regulator of blood-brain barrier integrity.
Gindorf M, Storck SE, Ohler A, Scharfenberg F, Becker-Pauly C, Pietrzik CU.
J Cereb Blood Flow Metab. 2021 Jan;41(1):31-44.
NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy.
Koerdel K, Spitzner M, Meyer T, Engels N, Krause F, Gaedcke J, Conradi LC, Haubrock M, Beißbarth T, Leha A, Johnsen SA, Ghadimi BM, Rose-John S, Grade M, Wienands J.
Cancers (Basel). 2021 Jan 26;13(3):455.
2020
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro.
Flynn CM, Garbers Y, Düsterhöft S, Wichert R, Lokau J, Lehmann CHK, Dudziak D, Schröder B, Becker-Pauly C, Rose-John S, Aparicio-Siegmund S, Garbers C.
Sci Rep. 2020 Dec 10;10(1):21612.
Characterization of the complex of the lysosomal membrane transporter MFSD1 and its accessory subunit GLMP.
Massa López D, Kählau L, Jungnickel KEJ, Löw C, Damme M.
FASEB J. 2020 Nov;34(11):14695-14709
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.
Adhikari B, Bozilovic J, Diebold M, Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, Dudvarski Stankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, Schlosser A, Heinzlmeir S, Sotriffer C, Knapp S*, Wolf E*.
Nat Chem Biol. 2020 Nov;16(11):1179-1188. *corresponding authors
Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis.
Rajeeve K, Vollmuth N, Janaki-Raman S, Wulff TF, Baluapuri A, Dejure FR, Huber C, Fink J, Schmalhofer M, Schmitz W, Sivadasan R, Eilers M, Wolf E, Eisenreich W, Schulze A, Seibel J, Rudel T.
Nat Microbiol. 2020 Nov;5(11):1390-1402.
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A.
EMBO Rep. 2020 Oct 5;21(10):e50241
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.
Gleitz HFE, Dugourd AJF, Leimkühler NB, Snoeren IAM, Fuchs SNR, Menzel S, Ziegler S, Kröger N, Triviai I, Büsche G, Kreipe H, Banjanin B, Pritchard JE, Hoogenboezem R, Bindels EM, Schumacher N, Rose-John S, Elf S, Saez-Rodriguez J, Kramann R, Schneider RK.
Blood. 2020 Oct 29;136(18):2051-2064.
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Werner- Klein M, Grujovic A, Irlbeck C, Obradović M, Hoffmann M, Koerkel-Qu H, Lu X, Treitschke S, Köstler C, Botteron C, Weidele K, Werno C, Polzer B, Kirsch S, Gužvić M, Warfsmann J, Honarnejad K, Czyz Z, Feliciello G, Blochberger I, Grunewald S, Schneider E, Haunschild G, Patwary N, Guetter S, Huber S, Rack B, Harbeck N, Buchholz S, Rümmele P, Heine N, Rose-John S, Klein CA.
Nat Commun. 2020 Oct 5;11(1):4977.
The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression.
Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W, Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M, Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E, Meierjohann S.
Oncogene. 2020 Oct;39(44):6841-6855.
IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants.
Bartsch YC, Eschweiler S, Leliavski A, Lunding HB, Wagt S, Petry J, Lilienthal GM, Rahmöller J, de Haan N, Hölscher A, Erapaneedi R, Giannou AD, Aly L, Sato R, de Neef LA, Winkler A, Braumann D, Hobusch J, Kuhnigk K, Krémer V, Steinhaus M, Blanchard V, Gemoll T, Habermann JK, Collin M, Salinas G, Manz RA, Fukuyama H, Korn T, Waisman A, Yogev N, Huber S, Rabe B, Rose-John S, Busch H, Berberich-Siebelt F, Hölscher C, Wuhrer M, Ehlers M.
J Allergy Clin Immunol. 2020 Sep;146(3):652-666.e11.
Letter to the Editor: Non-specific effects resulting from use of tocilizumab in mice.
Lokau J, Waetzig GH, Rose-John S, Garbers C.
Metabolism. 2020 Aug;109:154281.
LAMP-2 Is Involved in Surface Expression of RANKL of Osteoblasts In Vitro.
Jansen IDC, Tigchelaar-Gutter W, Hogervorst JMA, de Vries TJ, Saftig P, Everts V.
Int J Mol Sci. 2020 Aug 25;21(17):6110
IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Escrig A, Molinero A, Méndez B, Giralt M, Comes G, Sanchis P, Fernández-Gayol O, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J.
Cells. 2020 Jul 2;9(7):1605.
ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation.
Schumacher N, Rose-John S, Schmidt-Arras D.
Int J Mol Sci. 2020 Jul 20;21(14):5133.
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C.
Gut. 2020 Jul;69(7):1269-1282.
Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40.
Suire CN, Abdul-Hay SO, Sahara T, Kang D, Brizuela MK, Saftig P, Dickson DW, Rosenberry TL, Leissring MA.
Alzheimers Res Ther. 2020 Jul 6;12(1):80
The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis.
Saad MI, McLeod L, Yu L, Ebi H, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.
Carcinogenesis. 2020 Jun 17;41(4):527-538.
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.
Schwerd T, Krause F, Twigg SRF, Aschenbrenner D, Chen YH, Borgmeyer U, Müller M, Manrique S, Schumacher N, Wall SA, Jung J, Damm T, Glüer CC, Scheller J, Rose-John S, Jones EY, Laurence A, Wilkie AOM, Schmidt-Arras D, Uhlig HH.
Bone Res. 2020 Jun 11;8:24.
Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets.
Galgano D, Soheili T, Voss M, Torralba-Raga L, Tesi B, Cichocki F, Andre I, Rettig J, Cavazzana M, Bryceson Y.
Front Immunol. 2020 Jun 9;11:1154
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa G, Roeschert I, Prinz F, Baluapuri A, Vidal RS, Schülein-Völk C, Chang YC, Ade CP, Mastrobuoni G, Girard C, Kumar A, Wortmann L, Walz S, Lührmann R, Kempa S, Kuster B, Wolf E, Mumberg D, Eilers M.
Mol Cell. 2021 Jun 3;81(11):2495. Erratum for: Mol Cell. 2020 Mar 19;77(6):1322-1339.e11.
Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles.
Arnold P, Lückstädt W, Li W, Boll I, Lokau J, Garbers C, Lucius R, Rose-John S, Becker-Pauly C.
Cells. 2020 May 24;9(5):1307.
Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages.
Berner DK, Wessolowski L, Armbrust F, Schneppenheim J, Schlepckow K, Koudelka T, Scharfenberg F, Lucius R, Tholey A, Kleinberger G, Haass C, Arnold P, Becker-Pauly C.
FASEB J. 2020 May;34(5):6675-6687
Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles.
Arnold P, Lückstädt W, Li W, Boll I, Lokau J, Garbers C, Lucius R, Rose-John S, Becker-Pauly C.
Cells. 2020 May 24;9(5):1307
Soluble interleukin-6 receptor in patients with JAK2V617F somatic mutation and myeloproliferative neoplasm.
Garbers C, Rose-John S.
EClinicalMedicine. 2020 May 3;22:100340
Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells.
Lokau J, Kleinegger F, Garbers Y, Waetzig GH, Grötzinger J, Rose-John S, Haybaeck J, Garbers C.
PLoS One. 2020 May 4;15(5):e0232612
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Marques ARA, Di Spiezio A, Thießen N, Schmidt L, Grötzinger J, Lüllmann-Rauch R, Damme M, Storck SE, Pietrzik CU, Fogh J, Bär J, Mikhaylova M, Glatzel M, Bassal M, Bartsch U, Saftig P.
Autophagy. 2020 May;16(5):811-825
Target gene-independent functions of MYC oncoproteins.
Baluapuri A, Wolf E, Eilers M.
Nat Rev Mol Cell Biol. 2020 May;21(5):255-267.
The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M.
Cell Rep. 2020 Mar 10;30(10):3506-3519.e6
Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner.
Willis EF, MacDonald KPA, Nguyen QH, Garrido AL, Gillespie ER, Harley SBR, Bartlett PF, Schroder WA, Yates AG, Anthony DC, Rose-John S, Ruitenberg MJ, Vukovic J.
Cell. 2020 Mar 5;180(5):833-846
Interleukin-6 plays a critical role in aldosterone-induced macrophage recruitment and infiltration in the myocardium.
Liao CW, Chou CH, Wu XM, Chen ZW, Chen YH, Chang YY, Wu VC, Rose-John S, Hung CS, Lin YH; TAIPAI Study Group.
Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165627
The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M.
Cell Rep. 2020 Mar 10;30(10):3506-3519
Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease.
Manso AM, Hashem SI, Nelson BC, Gault E, Soto-Hermida A, Villarruel E, Brambatti M, Bogomolovas J, Bushway PJ, Chen C, Battiprolu P, Keravala A, Schwartz JD, Shah G, Gu Y, Dalton ND, Hammond K, Peterson K, Saftig P, Adler ED.
Sci Transl Med. 2020 Mar 18;12(535):eaax1744.
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.
Wünnemann F, Ta-Shma A, Preuss C, Leclerc S, van Vliet PP, Oneglia A, Thibeault M, Nordquist E, Lincoln J, Scharfenberg F, Becker-Pauly C, Hofmann P, Hoff K, Audain E, Kramer HH, Makalowski W, Nir A, Gerety SS, Hurles M, Comes J, Fournier A, Osinska H, Robins J, Pucéat M; MIBAVA Leducq Consortium principal investigators, Elpeleg O, Hitz MP, Andelfinger G.
Nat Genet. 2020 Jan;52(1):40-47
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C.
Cell Mol Life Sci. 2020 Jan;77(2):331-350
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C.
Cell Mol Life Sci. 2020 Jan;77(2):331-350
Targeting MYC Proteins for Tumor Therapy
Wolf E* and Eilers M*.
Annual Review of Cancer Biology, 2020, 4 *corresponding authors
2019
IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling.
Wilkinson AN, Chang K, Kuns RD, Henden AS, Minnie SA, Ensbey KS, Clouston AD, Zhang P, Koyama M, Hidalgo J, Rose-John S, Varelias A, Vuckovic S, Gartlan KH, Hill GR.
Blood. 2019 Dec 5;134(23):2092-2106
IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease.
Escrig A, Canal C, Sanchis P, Fernández-Gayol O, Montilla A, Comes G, Molinero A, Giralt M, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J.
Brain Behav Immun. 2019 Nov;82:145-159
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C.
FASEB J. 2019 Nov;33(11):11925-11940
IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease.
Escrig A, Canal C, Sanchis P, Fernández-Gayol O, Montilla A, Comes G, Molinero A, Giralt M, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J.
Brain Behav Immun. 2019 Nov;82:145-159
Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.
Notomi S, Ishihara K, Efstathiou NE, Lee JJ, Hisatomi T, Tachibana T, Konstantinou EK, Ueta T, Murakami Y, Maidana DE, Ikeda Y, Kume S, Terasaki H, Sonoda S, Blanz J, Young L, Sakamoto T, Sonoda KH, Saftig P, Ishibashi T, Miller JW, Kroemer G, Vavvas DG.
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23724-23734
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C.
FASEB J. 2019 Nov;33(11):11925-11940
A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A.
Nat Cell Biol. 2019 Nov;21(11):1413-1424.
Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells.
Otto C, Schmidt S, Kastner C, Denk S, Kettler J, Müller N, Germer CT, Wolf E, Gallant P, Wiegering A.
Neoplasia. 2019 Nov;21(11):1110-1120.
Treatment of type 2 diabetes with the designer cytokine IC7Fc.
Findeisen M, Allen TL, Henstridge DC, Kammoun H, Brandon AE, Baggio LL, Watt KI, Pal M, Cron L, Estevez E, Yang C, Kowalski GM, O'Reilly L, Egan C, Sun E, Thai LM, Krippner G, Adams TE, Lee RS, Grötzinger J, Garbers C, Risis S, Kraakman MJ, Mellet NA, Sligar J, Kimber ET, Young RL, Cowley MA, Bruce CR, Meikle PJ, Baldock PA, Gregorevic P, Biden TJ, Cooney GJ, Keating DJ, Drucker DJ, Rose-John S, Febbraio MA.
Nature. 2019 Oct;574(7776):63-68
The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP.
Massa López D, Thelen M, Stahl F, Thiel C, Linhorst A, Sylvester M, Hermanns-Borgmeyer I, Lüllmann-Rauch R, Eskild W, Saftig P, Damme M.
Elife. 2019 Oct 29;8
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Peters F, Becker-Pauly C.
Cancer Metastasis Rev. 2019 Sep;38(3):347-356. Review.
Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding.
Scharfenberg F, Armbrust F, Marengo L, Pietrzik C, Becker-Pauly C.
Cell Mol Life Sci. 2019 Aug;76(16):3193-3206. Review.
Interleukin 6 Dependent Synaptic Plasticity in a Social Defeat-Susceptible Prefrontal Cortex Circuit.
Esquivel-Rendón E, Vargas-Mireles J, Cuevas-Olguín R, Miranda-Morales M, Acosta-Mares P, García-Oscos F, Pineda JC, Salgado H, Rose-John S, Atzori M.
Neuroscience 2019 Aug 21;414:280-296
Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma.
Scherger AK, Al-Maarri M, Maurer HC, Schick M, Maurer S, Öllinger R, Gonzalez-Menendez I, Martella M, Thaler M, Pechloff K, Steiger K, Sander S, Ruland J, Rad R, Quintanilla-Martinez L, Wunderlich FT, Rose-John S, Keller U.
JCI Insight 2019 Aug 8;4(15)
The IL-6-neutralizing sIL-6R/sgp130 buffer system is disturbed in patients with type 2 diabetes.
Aparicio-Siegmund S, Garbers Y, Flynn CM, Waetzig GH, Gouni-Berthold I, Krone W, Berthold HK, Laudes M, Rose-John S, Garbers C.
Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E411-E420
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S*, Ikonen E*, Saftig P*, Neculai D*.
Nat Commun. 2019 Aug 6;10(1):3521
* Corresponding author
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
Dammert MA, Brägelmann J, Olsen RR, Böhm S, Monhasery N, Whitney CP, Chalishazar MD, Tumbrink HL, Guthrie MR, Klein S, Ireland AS, Ryan J, Schmitt A, Marx A, Ozretić L, Castiglione R, Lorenz C, Jachimowicz RD, Wolf E, Thomas RK, Poirier JT, Büttner R, Sen T, Byers LA, Reinhardt HC, Letai A, Oliver TG, Sos ML.
Nat Commun. 2019 Aug 2;10(1):3485.
MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.
Annunziata I, van de Vlekkert D, Wolf E, Finkelstein D, Neale G, Machado E, Mosca R, Campos Y, Tillman H, Roussel MF, Andrew Weesner J, Ellen Fremuth L, Qiu X, Han MJ, Grosveld GC, d'Azzo A.
Nat Commun. 2019 Aug 9;10(1):3623.
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.
Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C.
Int J Mol Sci. 2019 Jul 26;20(15)
Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.
Moreau D, Vacca F, Vossio S, Scott C, Colaco A, Paz Montoya J, Ferguson C, Damme M, Moniatte M, Parton RG, Platt FM, Gruenberg J.
EMBO Rep. 2019 Jul;20(7):e47055
A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five.
Khundadze M, Ribaudo F, Hussain A, Rosentreter J, Nietzsche S, Thelen M, Winter D, Hoffmann B, Afzal MA, Hermann T, de Heus C, Piskor EM, Kosan C, Franzka P, von Kleist L, Stauber T, Klumperman J, Damme M, Proikas-Cezanne T, Hübner CA.
Neurobiol Dis. 2019 Jul;127:419-431
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C.
Gut. Jul;69(7):1269-1282
The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients.
Dos Santos Guilherme M, Stoye NM, Rose-John S, Garbers C, Fellgiebel A, Endres K.
Front Aging Neurosci. 2019 Jul 23;11:182
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.
Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C.
Int J Mol Sci. 2019 Jul 26;20(15)
Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles.
Li X, Qin L, Li Y, Yu H, Zhang Z, Tao C, Liu Y, Xue Y, Zhang X, Xu Z, Wang Y, Lou H, Tan Z, Saftig P, Chen Z, Xu T, Bi G, Duan S, Gao Z.
Cell Rep. 2019 Jul 23;28(4):1015-1028.e5
Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes.
Pasquier A, Vivot K, Erbs E, Spiegelhalter C, Zhang Z, Aubert V, Liu Z, Senkara M, Maillard E, Pinget M, Kerr-Conte J, Pattou F, Marciniak G, Ganzhorn A, Ronchi P, Schieber NL, Schwab Y, Saftig P, Goginashvili A, Ricci R.
Nat Commun. 2019 Jul 25;10(1):3312
Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes.
Peters F, Scharfenberg F, Colmorgen C, Armbrust F, Wichert R, Arnold P, Potempa B, Potempa J, Pietrzik CU, Häsler R, Rosenstiel P, Becker-Pauly C.
FASEB J. 2019 Jun;33(6):7490-7504
Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3.
Servais FA, Kirchmeyer M, Hamdorf M, Minoungou NWE, Rose-John S, Kreis S, Haan C, Behrmann I.
Mol Ther Nucleic Acids. 2019 Jun 7;16:419-433
The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes.
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, von Eyss B, Gaubatz S.
Cell Rep. 2019 Jun 18;27(12):3533-3546.e7.
The cancer associated meprin β variant p.G32R provides an additional activation site and promotes cancer cell invasion.
Schäffler H, Li W, Helm O, Krüger S, Böger C, Peters F, Röcken C, Sebens S, Lucius R, Becker-Pauly C, Arnold P.
J Cell Sci. 2019 May 31;132(11)
Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation.
Pavlenko E, Cabron AS, Arnold P, Dobert JP, Rose-John S, Zunke F.
Int J Mol Sci. 2019 May 4;20(9)
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P, Poirier J, Saftig P, Bateman RJ, Breitner J, Hock C, Multhaup G.
Nat Commun. 2019 May 20;10(1):2240
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.
Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C.
J Clin Invest. 2019 May 6;129(6):2390-2403
MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation.
Baluapuri A*, Hofstetter J*, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E.
Mol Cell 2019 May 16;74(4):674-687.e11. *joint first authors
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Reinicke AT, Laban K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch PC, Duncan KE, Saftig P, Rinschen MM, Morellini F, Meyer-Schwesinger C.
Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7963-7972
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.
EMBO Mol Med. 2019 Apr;11(4)
Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.
Boon L, Ugarte-Berzal E, Martens E, Vandooren J, Rybakin V, Colau D, Gordon-Alonso M, van der Bruggen P, Stöcker W, Becker-Pauly C, Witters P, Morava-Kozics E, Jaeken J, Proost P, Opdenakker G.
FEBS J. 2019 Mar;286(5):930-945
ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury.
Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, Bogie J, Vanmierlo T, Vidal PM, Rose-John S, Gou-Fabregas M, Hendrix S.
Brain Behav Immun. 2019 Mar 6
Impaired mechanical, heat, and cold nociception in a murine model of genetic TACE/ADAM17 knockdown.
Quarta S, Mitrić M, Kalpachidou T, Mair N, Schiefermeier-Mach N, Andratsch M, Qi Y, Langeslag M, Malsch P, Rose-John S, Kress M.
FASEB J. 2019 Mar;33(3):4418-4431
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase.
Herold S, Kalb J, Büchel G, Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C, Dobbelstein M, Wolf E, Molenaar J, Versteeg R, Walz S, Eilers M.
Nature. 2019 Mar;567(7749):545-549.
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, Wiltfang J, Becker-Pauly C, Beher D, Pietrzik CU, Fraering PC, Wirths O, Weggen S.
Acta Neuropathol. 2019 Feb;137(2):239-257
Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.
Kleinegger F, Hofer E, Wodlej C, Golob-Schwarzl N, Birkl-Toeglhofer AM, Stallinger A, Petzold J,Orlova A, Krassnig S, Reihs R, Niedrist T, Mangge H, Park YN, Thalhammer M, Aigelsreiter A, Lax S, Garbers C, Fickert P, Rose-John S, Moriggl R, Rinner B, Haybaeck J.
Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):308-321
Correction to: A new multiple trauma model of the mouse.
Fitschen-Oestern S, Lippross S, Klueter T, Weuster M, Varoga D, Tohidnezhad M, Pufe T, Rose-John S, Andruszkow H, Hildebrand F, Steubesand N, Seekamp A, Neunaber C.
BMC Musculoskelet Disord. 2019 Feb 11;20(1):72
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Paige E, Clément M, Lareyre F, Sweeting M, Raffort J, Grenier C, Finigan A, Harrison J, Peters JE, Sun BB, Butterworth AS, Harrison SC, Bown MJ, Lindholt JS, Badger SA, Kullo IJ, Powell J, Norman PE, Scott DJA, Bailey MA, Rose-John S, Danesh J, Freitag DF, Paul DS, Mallat Z.
Circ Genom Precis Med. 2019 Feb;12(2):e002413
Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation byproteolytic cleavage.
Prenissl N, Lokau J, Rose-John S, Haybaeck J, Garbers C.
Cytokine. 2019 Feb;114:1-5
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Karmilin K, Schmitz C, Kuske M, Körschgen H, Olf M, Meyer K, Hildebrand A, Felten M, Fridrich S, Yiallouros I, Becker-Pauly C, Weiskirchen R, Jahnen-Dechent W, Floehr J, Stöcker W.
Sci Rep. 2019 Jan 24;9(1):546
Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.
Agthe M, Brügge J, Garbers Y, Wandel M, Kespohl B, Arnold P, Flynn CM, Lokau J, Aparicio-Siegmund S, Bretscher C, Rose-John S, Waetzig GH, Putoczki T, Grötzinger J, Garbers C.
Cell rep.2019 Jan;156(1):145-159.e19
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice.
Aden K, Bartsch K, Dahl J, Reijns MAM, Esser D, Sheibani-Tezerji R, Sinha A, Wottawa F, Ito G, Mishra N, Knittler K, Burkholder A, Welz L, van Es J, Tran F, Lipinski S, Kakavand N, Boeger C, Lucius R, von Schoenfels W, Schafmayer C, Lenk L, Chalaris A, Clevers H, Röcken C, Kaleta C, Rose-John S, Schreiber S, Kunkel T, Rabe B, Rosenstiel P.
Gastroenterology.2019 Jan;156(1):145-159.e19
Interleukin 6 Trans-Signalling and Risk of Future Cardiovascular Events.
Ziegler L, Gajulapuri A, Frumento P, Bonomi A, Wallén H, de Faire U, Rose-John S, Gigante B.
Cardiovasc Res 2019 Jan 1;115(1):213-221
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Reinicke AT, Laban K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch PC, Duncan KE, Saftig P, Rinschen MM, Morellini F, Meyer-Schwesinger C.
Proc Natl Acad Sci U S A. 2019; 116(16):7963-7972
The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
Niemeyer J , Mentrup T , Heidasch R, Mueller S, Biswas U, Meyer R, Papadopoulou A, Dederer V, Haug-Kroeper M, Adamski V, Lüllmann-Rauch R, Bergmann M, Mayerhofer A, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler S, Lemberg M, Schröder B.
EMBO R. 2019; 20(3):e46449
2018
The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.
Pohl S, Angermann A, Jeschke A, Hendrickx G, Yorgan TA, Makrypidi-Fraune G, Steigert A, Kuehn SC, Rolvien T, Schweizer M, Koehne T, Neven M, Winter O, Velho RV, Albers J, Streichert T, Pestka JM, Baldauf C, Breyer S, Stuecker R, Muschol N, Cox TM, Saftig P, Paganini C, Rossi A, Amling M, Braulke T, Schinke T.
J Bone Miner Res. 2018 Dec;33(12):2186-2201
Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity.
Talantikite M, Lécorché P, Beau F, Damour O, Becker-Pauly C, Ho WB, Dive V, Vadon-Le Goff S, Moali C.
FEBS Open Bio. 2018 Nov 12;8(12):2011-2021
PLD3 and spinocerebellar ataxia.
Gonzalez AC, Stroobants S, Reisdorf P, Gavin AL, Nemazee D, Schwudke D, D'Hooge R, Saftig P, Damme M.
Brain. 2018 Nov 1;141(11):e78.
Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe C, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A, Seufferlein T.
J Clin Invest 2018 Nov 1;128(11):5056-5072
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.
Cabron AS, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, Dobert JP, Pavlenko E, Schumacher N,Renné T, Taylor PR, Linder S, Rose-John S, Zunke F.
J Immunol 2018 Nov 15;201(10):3106-3118
PLD3 and spinocerebellar ataxia.
Gonzalez AC, Stroobants S, Reisdorf P, Gavin AL, Nemazee D, Schwudke D, D'Hooge R, Saftig P, Damme M.
Brain. 2018 Nov 1;141(11):e78
Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.
Biasin V, Wygrecka M, Bärnthaler T, Jandl K, Jain PP, Bálint Z, Kovacs G, Leitinger G, Kolb-Lenz D, Kornmueller K, Peters F, Sinn K, Klepetko W, Heinemann A, Olschewski A, Becker-Pauly C, Kwapiszewska G.
Thromb Haemost. 2018 Oct;118(10):1790-1802
Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis.
Stahl FR, Jung R, Jazbutyte V, Ostermann E, Tödter S, Brixel R, Kemmer A, Halle S, Rose-John S, Messerle M, Arck PC, Brune W, Renné T.
Sci Rep 2018 Oct 4;8(1):14823
A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans.
Khateb S, Kowalewski B, Bedoni N, Damme M, Pollack N, Saada A, Obolensky A, Ben-Yosef T, Gross M, Dierks T, Banin E, Rivolta C, Sharon D.
Genet Med. 2018 Sep;20(9):1004-1012
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.
Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D.
Nat Immunol. 2018 Sep;19(9):942-953
Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Nivarthi H, Gordziel C,Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S,Friedrich K, Moriggl R.
Oncotarget 2018 Sep 18;9(73):33865
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.
Seipold L, Altmeppen H, Koudelka T, Tholey A, Kasparek P, Sedlacek R, Schweizer M, Bär J, Mikhaylova M, Glatzel M, Saftig P.
Cell Mol Life Sci. 2018 Sep;75(17):3251-3267
Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells.
Lücke K, Yan I, Krohn S, Volmari A, Klinge S, Schmid J, Schumacher V, Steinmetz OM, Rose-John S, Mittrücker HW.
PLoS One 2018 Aug 31;13(8):e0203395
A RAB27A 5' untranslated region structural variant associated with late-onset hemophagocytic lymphohistiocytosis and normal pigmentation.
Tesi B, Rascon J, Chiang SCC, Burnyte B, Löfstedt A, Fasth A, Heizmann M, Juozapaite S, Kiudeliene R, Kvedaraite E, Miseviciene V, Muleviciene A, Müller ML, Nordenskjöld M, Matuzeviciene R, Samaitiene R, Speckmann C, Stankeviciene S, Zekas V, Voss M, Ehl S, Vaiciene-Magistris N, Henter JI, Meeths M, Bryceson YT.
J Allergy Clin Immunol. 2018 Jul;142(1):317-321.e8
Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice.
Holz K, Prinz M, Brendecke SM, Hölscher A, Deng F, Mitrücker HW, Rose-John S, Hölscher C.
Front Immunol 2018 May 2;9:836
Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma.
Kaiser K, Prystaz K, Vikman A, Haffner-Luntzer M, Bergdolt S, Strauss G, Waetzig GH, Rose-John S, Ignatius A.
Naunyn Schmiedebergs Arch Pharmacol 2018 May;391(5):523-536
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.
J Exp Med. 2018 Apr 2;215(4):1205-1225
Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome.
De Pace R, Skirzewski M, Damme M, Mattera R, Mercurio J, Foster AM, Cuitino L, Jarnik M, Hoffmann V, Morris HD, Han TU, Mancini GMS, Buonanno A, Bonifacino JS.
PLoS Genet. 2018 Apr 26;14(4):e1007363
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.
J Exp Med 2018 Apr 2;215(4):1205-1225
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.
Linsenmeier L, Mohammadi B, Wetzel S, Puig B, Jackson WS, Hartmann A, Uchiyama K, Sakaguchi S, Endres K, Tatzelt J, Saftig P, Glatzel M, Altmeppen HC.
Mol Neurodegener. 2018 Apr 6;13(1):18
RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.
Bartsch K, Damme M, Regen T, Becker L, Garrett L, Hölter SM, Knittler K, Borowski C, Waisman A, Glatzel M, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rabe B.
Front Immunol. 2018 Mar 29;9:587
BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.
Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K.
J Clin Invest 2018 Mar 1;128(3):916-930
Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7.
Pastor VB, Sahoo SS, Boklan J, Schwabe GC, Saribeyoglu E, Strahm B, Lebrecht D, Voss M, Bryceson YT, Erlacher M, Ehninger G, Niewisch M, Schlegelberger B, Baumann I, Achermann JC, Shimamura A, Hochrein J, Tedgård U, Nilsson L, Hasle H, Boerries M, Busch H, Niemeyer CM, Wlodarski MW.
Haematologica. 2018 Mar;103(3):427-437
The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpectedfunction of ADAM-17 in necroptosis.
Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D.
Oncotarget 2018 Feb 5;9(16):12941-12958
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.
Prystaz K, Kaiser K, Kovtun A, Haffner-Luntzer M, Fischer V, Rapp AE, Liedert A, Strauss G, Waetzig GH, Rose-John S, Ignatius A.
Am J Pathol. 2018 Feb;188(2):474-490
Snf1- RELATED KINASE1-Controlled C/S1-bZIP Signaling Activates Alternative Mitochondrial Metabolic Pathways to Ensure Plant Survival in Extended Darkness.
Pedrotti L, Weiste C, Nägele T, Wolf E, Lorenzin F, Dietrich K, Mair A, Weckwerth W, Teige M, Baena-González E, Dröge-Laser W.
Plant Cell. 2018 Feb;30(2):495-509.
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.
Gonzalez AC, Schweizer M, Jagdmann S, Bernreuther C, Reinheckel T, Saftig P, Damme M.
Cell Rep. 2018 Jan 23;22(4):1040-1053
Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer.
Garbers C, Rose-John S.
Methods Mol Biol. 2018;1725:127-140
The ADAM17 Metalloproteinase Maintains Arterial Elasticity.
Nicolaou A, Northoff BH, Zhao Z, Kohlmaier A, Sass K, Rose-John S, Steffens S, Weber C, Teupser D, Holdt LM.
Thromb Haemost 2018 Jan;118(1):210-213
Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.
Dixit A, Bottek J, Beerlage AL, Schuettpelz J, Thiebes S, Brenzel A, Garbers C, Rose-John S, Mittrücker HW, Squire A, Engel DR.
J Leukoc Biol. 2018 Jan;103(1):13-22
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.
Gonzalez AC, Schweizer M, Jagdmann S, Bernreuther C, Reinheckel T, Saftig P, Damme M.
Cell Rep. 2018 Jan 23;22(4):1040-1053
2017
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.
Conrad KS, Cheng TW, Ysselstein D, Heybrock S, Hoth LR, Chrunyk BA, Am Ende CW, Krainc D, Schwake M, Saftig P, Liu S, Qiu X, Ehlers MD.
Nat Commun. 2017 Dec 4;8(1):1908
Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.
Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M.
Cell Rep. 2017 Dec 19;21(12):3483-3497.
Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.
Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.
Cell Rep. 2017 Nov 21;21(8):2090-2103
Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis.
Arnold P, Otte A, Becker-Pauly C.
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2096-2104. Review.
Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Hölscher C.
Front Immunol. 2017 Nov 10;8:1537
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, Maystadt I, Füchtbauer A, Füchtbauer EM, Jablonka S, Blum R, Üçeyler N, Petri S, Kaltschmidt B, Jahn R, Kaltschmidt C, Sendtner M.
Nat Commun. 2017 Oct 30;8(1):678
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.
Bartsch K, Knittler K, Borowski C, Rudnik S, Damme M, Aden K, Spehlmann ME, Frey N, Saftig P, Chalaris A, Rabe B.
Hum Mol Genet. 2017 Oct 15;26(20):3960-3972
Long- term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R.
Neurobiol Dis. 2017 Oct;106:255-268
The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.
Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.
Oncoimmunology 2017 Oct 26;7(1):e1368603
Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.
Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.
Front Physiol. 2017 Oct 9;8:775
Long- term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R.
Neurobiol Dis. 2017 Oct;106:255-268
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.
Bartsch K, Knittler K, Borowski C, Rudnik S, Damme M, Aden K, Spehlmann ME, Frey N, Saftig P, Chalaris A, Rabe B.
Hum Mol Genet. 2017 Oct 15;26(20):3960-3972
PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters.
Gerlach JM, Furrer M, Gallant M, Birkel D, Baluapuri A, Wolf E, Gallant P.
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9224-E9232.
The role of ADAM17 in the T-cell response against bacterial pathogens.
Link MA, Lücke K, Schmid J, Schumacher V, Eden T, Rose-John S, Mittrücker HW.
PLoS One. 2017 Sep 6;12(9):e0184320
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, Saftig P, Van Damme P.
Hum Mol Genet. 2017 Aug 1;26(15):2850-2863
Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice.
Tode J, Richert E, Koinzer S, Klettner A, Pickhinke U, Garbers C, Rose-John S, Nölle B, Roider J.
Cytokine. 2017 Aug;96:8-15
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, Saftig P, Van Damme P.
Hum Mol Genet. 2017 Aug 1;26(15):2850-2863
Cancer- associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C.
Oncotarget. 2017 Jul 4;8(33):54873-54888
Meprin β and BMP-1 are differentially regulated by CaCl2.
Schneppenheim J, Scharfenberg F, Lucius R, Becker-Pauly C, Arnold P.
Cell Calcium. 2017 Jul;65:8-13
Cancer- associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C.
Oncotarget 2017 Jul 4;8(33):54873-54888
EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.
Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M.
Gastroenterology 2017 Jul;153(1):178-190.e10
The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments.
Schneppenheim J, Loock AC, Hüttl S, Schweizer M, Lüllmann-Rauch R, Oberg HH, Arnold P, Lehmann CHK, Dudziak D, Kabelitz D, Lucius R, Lennon-Duménil AM, Saftig P, Schröder B.
J Immunol. 2017 Jul 1;199(1):172-185
Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.
Cheng S, Wani WY, Hottman DA, Jeong A, Cao D, LeBlanc KJ, Saftig P, Zhang J, Li L.
J Neurochem. 2017 Jul;142(2):297-304
Functional characterization of the lysosomal membrane protein TMEM192 in mice.
Nguyen TL, Schneppenheim J, Rudnik S, Lüllmann-Rauch R, Bernreuther C, Hermans-Borgmeyer I, Glatzel M, Saftig P, Schröder B.
Oncotarget. 2017 Jul 4;8(27):43635-43652
The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.
Dejure FR, Royla N, Herold S, Kalb J, Walz S, Ade CP, Mastrobuoni G, Vanselow JT, Schlosser A, Wolf E, Kempa S, Eilers M.
EMBO J. 2017 Jul 3;36(13):1854-1868.
Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S.
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8029-8034.
Over- expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.
Kammoun HL, Allen TL, Henstridge DC, Kraakman MJ, Peijs L, Rose-John S, Febbraio MA.
PLoS One. 2017 Jun 20;12(6):e0179099
IL6- Dependent Genomic Instability Heralds Accelerated Carcinogenesis Following Liver Regeneration on a Background of Chronic Hepatitis.
Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, Rosenberg N, Paldor M, Goldenberg D, Sonnenblick A, Peled A, Rose-John S, Galun E, Axelrod JH.
Hepatology. 2017 May;65(5):1600-1611
Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.
Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose-John S, Knolle PA, Wohlleber D.
J Hepatol. 2017 May;66(5):978-986
IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.
Timper K, Denson JL, Steculorum SM, Heilinger C, Engström-Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT, Brüning JC.
Cell Rep. 2017 Apr 11;19(2):267-280
The balance between Treg and TH17 cells: CD11b and interleukin-6.
Garbers C, Rose-John S.
Eur J Immunol. 2017 Apr;47(4):629-632
Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
Balic JJ, Garbers C, Rose-John S, Yu L, Jenkins BJ.
Cytokine. 2017 Apr;92:118-123
Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.
Sontag S, Förster M, Qin J, Wanek P, Mitzka S, Schüler HM, Koschmieder S, Rose-John S, Seré K, Zenke M.
Stem Cells. 2017 Apr;35(4):898-908
Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.
Kissing S, Rudnik S, Damme M, Lüllmann-Rauch R, Ichihara A, Kornak U, Eskelinen EL, Jabs S, Heeren J, De Brabander JK, Haas A, Saftig P.
Autophagy. 2017 Apr 3;13(4):670-685
Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules.
Schulze U, Brast S, Grabner A, Albiker C, Snieder B, Holle S, Schlatter E, Schröter R, Pavenstädt H, Herrmann E, Lambert C, Spoden GA, Florin L, Saftig P, Ciarimboli G.
FASEB J. 2017 Apr;31(4):1421-1433
Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms.
Tesi B*, Davidsson J*, Voss M*, Rahikkala E, Holmes TD, Chiang SCC, Komulainen-Ebrahim J, Gorcenco S, Rundberg Nilsson A, Ripperger T, Kokkonen H, Bryder D, Fioretos T, Henter JI, Möttönen M, Niinimäki R, Nilsson L, Pronk CJ, Puschmann A, Qian H, Uusimaa J, Moilanen J, Tedgård U, Cammenga J, Bryceson YT.
Blood. 2017 Apr 20;129(16):2266-2279
Natural killer cell biology illuminated by primary immunodeficiency syndromes in humans.
Voss M, Bryceson YT.
Clin Immunol. 2017 Apr;177:29-42
OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M.
Oncogene. 2017 Apr 6;36(14):1911-1924.
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.
Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C.
FASEB J. 2017 Mar;31(3):1226-1237
Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.
Kissing S, Rudnik S, Damme M, Lüllmann-Rauch R, Ichihara A, Kornak U, Eskelinen EL, Jabs S, Heeren J, De Brabander JK, Haas A, Saftig P.
Mol Cell Proteomics. 2017 Mar;16(3):438-450
Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II.
Markmann S, Krambeck S, Hughes CJ, Mirzaian M, Aerts JM, Saftig P, Schweizer M, Vissers JP, Braulke T, Damme M.
Mol Cell Proteomics. 2017 Mar;16(3):438-450
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.
Sci Rep. 2017 Mar 9;7:44053
Instructive Role of the Microenvironment in Preventing Renal Fibrosis.
Matsumoto K, Xavier S, Chen J, Kida Y, Lipphardt M, Ikeda R, Gevertz A, Caviris M, Hatzopoulos AK, Kalajzic I, Dutton J, Ratliff BB, Zhao H, Darzynkiewicz Z, Rose-John S, Goligorsky MS.
Stem Cells Transl Med. 2017 Mar;6(3):992-1005
Sequestration of cholesterol within the host late endocytic pathway restricts liver-stage Plasmodium development.
Petersen W, Stenzel W, Silvie O, Blanz J, Saftig P, Matuschewski K, Ingmundson A.
Mol Biol Cell. 2017 Mar 15;28(6):726-735
Quantitative proteome analysis of mouse liver lysosomes provides evidence for mannose 6-phosphate-independent targeting mechanisms of acid hydrolases in mucolipidosis II.
Markmann S, Krambeck S, Hughes CJ, Mirzaian M, Aerts JM, Saftig P, Schweizer M, Vissers JC, Braulke T, Damme M.
Mol Cell Proteomics. 2017 Mar;16(3):438-450
Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice.
Arnold P, Koopmann L, Peters F, Birkenfeld , Goff SV, Damm T, Qin C, Moali C, Lucius R, Becker-Pauly C.
Cell Tissue Res. 2017 Feb;367(2):351-358
Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth.
Burger R, Günther A, Klausz K, Staudinger M, Peipp M, Penas EM, Rose-John S, Wijdenes J, Gramatzki M.
Haematologica. 2017 Feb;102(2):381-390
Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM.
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):247-257
The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.
Becker-Pauly C, Pietrzik CU.
Front Mol Neurosci. 2017 Jan 5;9:159. Review.
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.
Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.
Front Mol Neurosci. 2017 Jan 5;9:159
Meprin β contributes to collagen deposition in lung fibrosis.
Biasin V, Wygrecka M, Marsh LM, Becker-Pauly C, Brcic L, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G.
Sci Rep. 2017 Jan 6;7:39969
Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.
Breig O, Yates M, Neaud V, Couchy G, Grigoletto A, Lucchesi C, Prox J, Zucman-Rossi J, Becker-Pauly C, Rosenbaum J.
Oncotarget. 2017 Jan 31;8(5):7839-7851
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P.
Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):217-230
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.
Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.
PLoS Biol. 2017 Jan 6;15(1):e2000080
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.
Nat Immunol. 2017 Jan;18(1):74-85
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.
Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D.
Hepatology. 2017 Jan;65(1):89-103
Intermittent Fasting Preserves Beta-Cell Mass in Obesity-induced Diabetes via the Autophagy-Lysosome Pathway.
Liu H, Javaheri A, Godar RJ, Murphy J, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, McDaniel ML, Remedi MS, Razani B, Urano F, Diwan A.
Autophagy. 2017;13(11):1952-1968
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P.
Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):217-230
Serum Starvation Induces BACE1 Processing and Secretion.
Stavropoulou AV, Mavrofrydi O, Saftig P, Efthimiopoulos S.
Curr Alzheimer Res. 2017;14(4):453-459
2016
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate.
Madoux F, Dreymuller D, Pettiloud JP, Santos R, Becker-Pauly C, Ludwig A, Fields GB, Bannister T, Spicer TP, Cudic M, Scampavia LD, Minond D.
Sci Rep. 2016 Dec 5;6(1):11
Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.
Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ.
Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.
Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P.
Oncogenesis. 2016 Nov 21;5(11):e270
Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.
Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.
J Immunol. 2016 Nov 1;197(9):3705-3715
Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts.
Heckt T, Keller J, Peters S, Streichert T, Chalaris A, Rose-John S, Mell B, Joe B, Amling M, Schinke T.
Bone. 2016 Nov;92:85-93
Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver.
Grünwald B, Harant V, Schaten S, Frühschütz M, Spallek R, Höchst B, Stutzer K, Berchtold S, Erkan M, Prokopchuk O, Martignoni M, Esposito I, Heikenwalder M, Gupta A, Siveke J, Saftig P, Knolle P, Wohlleber D, Krüger A.
Gastroenterology. 2016 Nov;151(5):1011-1024.e7
The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells.
King B, Boccalatte F, Moran-Crusio K, Wolf E, Wang J, Kayembe C, Lazaris C, Yu X, Aranda-Orgilles B, Lasorella A, Aifantis I.
Nat Immunol. 2016 Nov;17(11):1312-1321.
Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.
Kalinin DV, Wagner S, Riemann B, Hermann S, Schmidt F, Becker-Pauly C, Rose-John S, Schäfers M, Holl R.
J Med Chem. 2016 Oct 27;59(20):9541-9559
Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains.
Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, Becker-Pauly C.
Biol Chem. 2016 Sep 1;397(9):857-69
A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease.
Wolf H, Damme M, Stroobants S, D'Hooge R, Beck HC, Hermans-Borgmeyer I, Lüllmann-Rauch R, Dierks T, Lübke T.
Dis Model Mech. 2016 Sep 1;9(9):1015-28
The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2.
Beckmann AM, Glebov K, Walter J, Merkel O, Mangold M, Schmidt F, Becker-Pauly C, Gütschow M, Stirnberg M.
Biol Chem. 2016 Aug 1;397(8):777-90
ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A.
JCI Insight. 2016 Aug 18;1(13)
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response.
Heim D, Gil-Ibanez I, Herden J, Parplys AC, Borgmann K, Schmidt-Arras D, Lohse AW, Rose-John S, Wege H.
Oncotarget. 2016 Aug 23;7(34):55639-55648
Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A.
Elife. 2016 Aug 1;5
Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling.
Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, Garbers C.
J Biol Chem. 2016 Jul 29;291(31):16186-96
Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.
Wörmann SM, Song L, Ai J, Diakopoulos KN, Kurkowski MU, Görgülü K, Ruess D, Campbell A, Doglioni C, Jodrell D, Neesse A, Demir IE, Karpathaki AP, Barenboim M, Hagemann T, Rose-John S, Sansom O, Schmid RM, Protti MP, Lesina M, Algül H.
Gastroenterology. 2016 Jul;151(1):180-193.e12
Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer.
Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K
Gut. 2016 Jul;65(7):1139-50
Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models.
Becker-Pauly C, Pietrzik CU.
EBioMedicine. 2016 Jul;9:19-20
Dissecting the role of ADAM10 as a mediator of S. aureus α-toxin action.
von Hoven G, Rivas AJ, Neukirch C, Klein S, Hamm C, Qin Q, Meyenburg M, Füser S, Saftig P, Hellmann N, Postina R, Husmann M.
Biochem J. 2016 Jul 1;473(13):1929-40
Different promoter affinities account for specificity in MYC-dependent gene regulation.
Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E.
Elife. 2016 Jul 27;5:e15161.
The role of interleukin-6 signaling in nervous tissue.
Rothaug M, Becker-Pauly C, Rose-John S.
Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1218-27. Review.
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.
Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, Barrett DM, Weiss SL, Fitzgerald JC, Berg RA, Aplenc R, Callahan C, Rheingold SR, Zheng Z, Rose-John S, White JC, Nazimuddin F, Wertheim G, Levine BL, June CH, Porter DL, Grupp SA.
Cancer Discov. 2016 Jun;6(6):664-79
Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.
Demeestere D, Dejonckheere E, Steeland S, Hulpiau P, Haustraete J, Devoogdt N, Wichert R, Becker-Pauly C, Van Wonterghem E, Dewaele S, Van Imschoot G, Aerts J, Arckens L, Saeys Y, Libert C, Vandenbroucke RE.
Mol Ther. 2016 May;24(5):890-902
Human and murine Interleukin 23 receptors are novel substrates for a disintegrin and metalloproteases ADAM10 and ADAM17.
Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J.
J Biol Chem. 2016 May 13;291(20):10551-61
Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.
Riethmueller S, Ehlers JC, Lokau J, Düsterhöft S, Knittler K, Dombrowsky G, Grötzinger J, Rabe B, Rose-John S, Garbers C.
Sci Rep. 2016 May 6;6:25550
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.
Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker HW, Chalaris A.
J Leukoc Biol. 2016 May;99(5):749-60
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.
Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker HW, Chalaris A.
J Leukoc Biol. 2016 May;99(5):749-60
Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74.
Hüttl S, Helfrich F, Mentrup T, Held S, Fukumori A, Steiner H, Saftig P, Fluhrer R, Schröder B.
Biochem J. 2016 May 15;473(10):1405-22
Cathepsin K Deficiency Suppresses Disuse-Induced Bone Loss.
Moriya S, Izu Y, Arayal S, Kawasaki M, Hata K, Pawaputanon Na Mahasarakhahm C, Izumi Y, Saftig P, Kaneko K, Noda M, Ezura Y.
J Cell Physiol. 2016 May;231(5):1163-70
Age-dependent development of liver fibrosis in Glmpgt/gt mice.
Cecilie K. Nesset, Xiang Yi Kong, Markus Damme, Camilla Schjalm, Norbert Roos, Else Marit Løberg and Winnie Eskild.
Fibrogenesis Tissue Repair. 2016 Apr 28;9:5
Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts.
Malysheva K, de Rooij K, Lowik CW, Baeten DL, Rose-John S, Stoika R, Korchynskyi O.
Croat Med J. 2016 Apr 23;57(2):89-98
Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.
Birner P, Heider S, Petzelbauer P, Wolf P, Kornauth C, Kuroll M, Merkel O, Steiner G, Kishimoto T, Rose-John S, Soleiman A, Moriggl R, Kenner L.
Exp Dermatol. 2016 Apr;25(4):305-10
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D.
Oncotarget. 2016 Apr 5;7(14):17431-41.
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2.
Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M.
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3791-6
Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 delivery to lamellar bodies accounts for altered alveolar phospholipid content in Adaptor Protein-3-deficient pearl mice.
Kook S, Wang P, Young L, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S.
J Biol Chem. 2016 Apr 15;291(16):8414-27
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D.
Oncotarget. 2016 Apr 5;7(14):17431-41
Determination of Cleavage Site of Reelin between Its Sixth and Seventh Repeat and Contribution of Meprin Metalloproteases to the Cleavage.
Sato Y, Kobayashi D, Kohno T, Kidani Y, Prox J, Becker-Pauly C, Hattori M.
J Biochem. 2016 Mar;159(3):305-12
Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice.
Kruszewski K, Lüllmann-Rauch R, Dierks T, Bartsch U, Damme M.
nvest Ophthalmol Vis Sci. 2016 Mar;57(3):1120-31
Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation.
Marmary Y, Adar R, Gaska S, Wygoda A, Maly A, Cohen J, Eliashar R, Mizrachi L, Orfaig-Geva C, Baum BJ, Rose-John S, Galun E, Axelrod JH.
Cancer Res. 2016 Mar 1;76(5):1170-80
Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA.
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3006-11
Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site.
Schönherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU.
Mol Neurodegener. 2016 Feb 19;11:19
KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.
Rosean TR, Holman CJ, Tompkins VS, Jing X, Krasowski MD, Rose-John S, Janz S.
Blood Cancer J. 2016 Feb 26;6:e398
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C.
Cell Rep. 2016 Feb 23;14(7):1761-1773
A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.
Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C.
Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6
IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.
Brooks GD, McLeod L, Alhayyani S, Miller A, Russell PA, Ferlin W, Rose-John S, Ruwanpura S, Jenkins BJ.
Cancer Res. 2016 Feb 15;76(4):866-76
LAMP proteins account for the maturation delay during the establishment of the Coxiella burnetii-containing vacuole.Schulze-Luehrmann J, Eckart RA, Ölke M, Saftig P, Liebler-Tenorio E, Lührmann A.
Cell Microbiol. 2016 Feb;18(2):181-94
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Klionsky DJ, ..., Damme M, ..., Zughaier SM.
Autophagy. 2016 Jan 2;12(1):1-222.
IL-6 Trans-Signaling Drives Murine Crescentic GN.
Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J
J Am Soc Nephrol. 2016 Jan;27(1):132-42
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Klionsky DJ, ..., Saftig P, ..., Zughaier SM.
Autophagy. 2016;12(1):1-222
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.
Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF.
Elife. 2016 Jan 23;5:e12748
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C.
J Biol Chem. 2016 Jan 1;291(1):318-33.
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
Vo BT*, Wolf E*, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M, Roussel MF.
Cancer Cell. 2016 Jan 11;29(1):5-16. *joint first authors
Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.
Jaenicke LA, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg AK, Geyer M, Eilers M, Popov N.
Mol Cell. 2016 Jan 7;61(1):54-67.
2015
Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells.
Holmer R, Wätzig GH, Tiwari S, Rose-John S, Kalthoff H.
BMC Cancer. 2015 Dec 16;15:975.
Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.
Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R.
EMBO Rep. 2015 Dec;16(12):1723-36.
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.
Blanz J, Zunke F, Markmann S, Damme M, Braulke T, Saftig P, Schwake M.
Traffic. 2015 Oct;16(10):1127-36
Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles.
Schumacher N, Meyer D, Mauermann A, von der Heyde J, Wolf J, Schwarz J, Knittler K, Murphy G, Michalek M, Garbers C, Bartsch JW, Guo S, Schacher B, Eickholz P, Chalaris A, Rose-John S, Rabe B.
J Biol Chem. 2015 Oct 23;290(43):26059-71
Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
Grill M, Syme TE, Noçon AL, Lu AZ, Hancock D, Rose-John S, Campbell IL
Glia. 2015 Oct;63(10):1738-52
Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation.
Ullah MA, Revez JA, Loh Z, Simpson J, Zhang V, Bain L, Varelias A, Rose-John S, Blumenthal A, Smyth MJ, Hill GR, Sukkar MB, Ferreira MA, Phipps S
J Allergy Clin Immunol. 2015 Oct;136(4):1065-73
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.
Blanz J, Zunke F, Markmann S, Damme M, Braulke T, Saftig P, Schwake M.
Traffic. 2015 Oct;16(10):1127-36
Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4.
Bonaccorso RL, Chepurny OG, Becker-Pauly C, Holz GG, Doyle RP.
Mol Pharm. 2015 Sep 8;12(9):3502-6
Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice.
Damme M, Stroobants S, Lüdemann M, Rothaug M, Lüllmann-Rauch R, Beck HC, Ericsson A, Andersson C, Fogh J, D'Hooge R, Saftig P, Blanz J.
Ann Clin Transl Neurol. 2015 Sep 19;2(11):987-1001
Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer.
Goumas FA, Holmer R, Egberts JH, Gontarewicz A, Heneweer C, Geisen U, Hauser C, Mende MM, Legler K, Röcken C, Becker T, Waetzig GH, Rose-John S, Kalthoff H
Int J Cancer. 2015 Sep 1;137(5):1035-46
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.
Kreins AY, Ciancanelli MJ, Okada S, Kong XF, Ramírez-Alejo N, Kilic SS, El Baghdadi J, Nonoyama S, Mahdaviani SA, Ailal F, Bousfiha A, Mansouri D, Nievas E, Ma CS, Rao G, Bernasconi A, Sun Kuehn H, Niemela J, Stoddard J, Deveau P, Cobat A, El Azbaoui S, Sabri A, Lim CK, Sundin M, Avery DT, Halwani R, Grant AV, Boisson B, Bogunovic D, Itan Y, Moncada-Velez M, Martinez-Barricarte R, Migaud M, Deswarte C, Alsina L, Kotlarz D, Klein C, Muller-Fleckenstein I, Fleckenstein B, Cormier-Daire V, Rose-John S, Picard C, Hammarstrom L, Puel A, Al-Muhsen S, Abel L, Chaussabel D, Rosenzweig SD, Minegishi Y, Tangye SG, Bustamante J, Casanova JL, Boisson-Dupuis S.
J Exp Med. 2015 Sep 21;212(10):1641-62
Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice.
Damme D, Stroobants S, Lüdemann M, Rothaug M, Lüllmann-Rauch R, Beck HC, Ericsson A, Andersson C, Fogh J, D’Hooge R, Saftig P, Blanz J.
Ann Clin Transl Neurol. 2015 Sep 19;2(11):987-1001
Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
Jäckle F, Schmidt F, Wichert R, Arnold P, Prox J, Mangold M, Ohler A, Pietrzik CU, Koudelka T, Tholey A, Gütschow M, Stirnberg M, Becker-Pauly C.
Biochem J. 2015 Aug 15;470(1):91-103
Calcium negatively regulates meprin β activity and attenuates substrate cleavage.
Arnold P, Schmidt F, Prox J, Zunke F, Pietrzik C, Lucius R, Becker-Pauly C.
FASEB J. 2015 Aug;29(8):3549-57
In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11.
Varga RE, Khundadze M, Damme M, Nietzsche S, Hoffmann B, Stauber T, Koch N, Hennings JC, Franzka P, Huebner AK, Kessels MM, Biskup C, Jentsch TJ, Qualmann B, Braulke T, Kurth I, Beetz C, Hübner CA.
PLoS Genet. 2015 Aug 18;11(8):e1005454
Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells.
Hüttl S, Kläsener K, Schweizer M, Schneppenheim J, Oberg HH, Kabelitz D, Reth M, Saftig P, Schröder B.
J Immunol. 2015 Aug 15;195(4):1548-63
TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice.
Kobuch J, Cui H, Grünwald B, Saftig P, Knolle PA, Krüger A.
Haematologica. 2015 Aug;100(8):1005-13
A cell-based assay reveals nuclear translocation of intracellular domains released by SPPL proteases.
Mentrup, T., Häsler,R., Fluhrer, R., Saftig, P., Schröder, B.
Traffic. 2015 Aug;16(8):871-92
Meprin α and meprin β: Procollagen proteinases in health and disease.
Prox J, Arnold P, Becker-Pauly C.
Matrix Biol. 2015 May-Jul;44-46:7-13
STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.
Nat Commun. 2015 Jul 22;6:7736
A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.
Hong SS, Choi JH, Lee SY, Park YH, Park KY, Lee JY, Kim J, Gajulapati V, Goo JI, Singh S, Lee K, Kim YK, Im SH, Ahn SH, Rose-John S, Heo TH, Choi Y.
J Immunol. 2015 Jul 1;195(1):237-45
Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RA, Panzer U, Steinmetz OM.
J Am Soc Nephrol. 2015 Jul;26(7):1597-607
LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation.
Küspert M, Murakawa Y, Schäffler K, Vanselow JT, Wolf E, Juranek S, Schlosser A, Landthaler M, Fischer U.
RNA. 2015 Jul;21(7):1294-305.
Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver.
Kong XY, Kase ET, Herskedal A, Schjalm C, Damme M, Nesset CK, Thoresen GH, Rustan AC, Eskild W.
PLoS One. 2015 Jun 5;10(6):e0129402
Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages.
Beyer C, Huang J, Beer J, Zhang Y, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Maier C, Munoz L, Krönke G, Uderhardt S, Distler O, Jones S, Rose-John S, Oravecz T, Schett G, Distler JH
Ann Rheum Dis. 2015 Jun;74(6):1317-24
Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat.
Garcia- Oscos F, Peña D, Housini M, Cheng D, Lopez D, Cuevas-Olguin R, Saderi N, Salgado Delgado R, Galindo Charles L, Salgado Burgos H, Rose-John S, Flores G, Kilgard MP, Atzori M
J Neurosci Res. 2015 Jun;93(6):859-65
Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.
Kuhn PH*, Voss M*, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R.
Mol Cell Proteomics. 2015 Jun;14(6):1584-98
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.
Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M.
EMBO J. 2015 Jun 3;34(11):1554-71.
Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma.
Mackiewicz J, Karczewska-Dzionk A, Laciak M, Kapcinska M, Wiznerowicz M, Burzykowski T, Zakowska M, Rose-John S, Mackiewicz A.
Medicine (Baltimore). 2015 May;94(21):e853
IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans.
Müller N, Schulte DM, Türk K, Freitag-Wolf S, Hampe J, Zeuner R, Schröder JO, Gouni-Berthold I, Berthold HK, Krone W, Rose-John S, Schreiber S, Laudes M
J Lipid Res. 2015 May;56(5):1034-42
Vacuolar ATPase in Phagosome-Lysosome Fusion.
Kissing S, Hermsen C, Repnik U, Nesset CK, von Bargen K, Griffiths G, Ichihara A, Lee BS, Schwake M, De Brabander J, Haas A, Saftig P.
J Biol Chem. 2015 May 29;290(22):14166-80
Evaluation of ¹¹¹In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers.
Jodal A, Pape F, Becker-Pauly C, Maas O, Schibli R, Béhé M.
PLoS One. 2015 Apr 9;10(4):e0123443
Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III).
Kowalewski B, Heimann P, Ortkras T, Lüllmann-Rauch R, Sawada T, Walkley SU, Dierks T, Damme M.
Hum Mol Genet. 2015 Apr 1;24(7):1856-68
Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.
van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM
Am J Pathol. 2015 Apr;185(4):1145-55
Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis.
van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM.
Am J Pathol. 2015 Apr;185(4):1145-55
snoRNAs are a novel class of biologically relevant Myc targets.
Herter EK, Stauch M, Gallant M, Wolf E, Raabe T, Gallant P.
BMC Biol. 2015 Apr 16;13:25.
Taming of the beast: shaping Myc-dependent amplification.
Wolf E, Lin CY, Eilers M, Levens DL.
Trends Cell Biol. 2015 Apr;25(4):241-8.
Review:Autophagy in neuronal cells: general principles and physiological and pathological functions.
Damme M, Suntio T, Saftig P, Eskelinen EL.
Acta Neuropathol. 2015 Mar;129(3):337-62
Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.
Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, EstevezE, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S,Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A,Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA
Cell Metab. 2015 Mar 3;21(3):403-16
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease.
Peters J, Rittger A, Weisner R, Knabbe J, Zunke F, Rothaug M, Damme M, Berkovic SF, Blanz J, Saftig P, Schwake M.
Biochem Biophys Res Commun. 2015 Feb 13;457(3):334-40
Pharmaceutical relevant cytokine receptors: lessons from the first drafts of the human proteome.
Garbers C, Rose-John S
J Proteome Res. 2015 Feb 6;14(2):1330-2
The sheddase ADAM10 is a potent modulator of prion disease.
Altmeppen HC, Prox J, Krasemann S, Puig B, Kruszewski K, Dohler F, Bernreuther C, Hoxha A, Linsenmeier L, Sikorska B, Liberski PP, Bartsch U, Saftig P, Glatzel M.
Elife. 2015 Feb 5;4:e04260
β-Secretase BACE1 Regulates Hippocampal and Reconstituted M-Currents in a β-Subunit-Like Fashion.
Hessler S, Zheng F, Hartmann S, Rittger A, Lehnert S, Völkel M, Nissen M, Edelmann E, Saftig P, Schwake M, Huth T, Alzheimer C.
J Neurosci. 2015 Feb 25;35(8):3298-311
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease.
Peters J, Rittger A, Weisner R, Knabbe J, Zunke F, Rothaug M, Damme M, Berkovic SF, Blanz J, Saftig P, Schwake M.
Biochem Biophys Res Commun. 2015 Feb 13;457(3):334-40
Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.
Weber D, Heisig J, Kneitz S, Wolf E, Eilers M, Gessler M.
J Mol Cell Cardiol. 2015 Feb;79:79-88.
Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier.
Okada R, Wu Z, Zhu A, Ni J, Zhang JQ, Yoshimine Y, Peters C, Saftig P, Nakanishi H.
Mol Cell Neurosci. 2015 Jan;64:51-60
RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity.
Mittelberger F, Meyer C, Waetzig GH, Zacharias M, Valentini E, Svergun DI, Berg K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U.
RNA Biol. 2015;12(9):1043-53
ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis.
Caolo V, Swennen G, Chalaris A, Wagenaar A, Verbruggen S, Rose-John S, Molin DG, Vooijs M, Post MJ
Angiogenesis. 2015 Jan;18(1):13-22
Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M.
Hsu MP, Frausto R, Rose-John S, Campbell IL
Glia. 2015 Jan;63(1):132-41
Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex.
Garcia-Oscos F, Peña D, Housini M, Cheng D, Lopez D, Borland MS, Salgado-Delgado R, Salgado H, D'Mello S, Kilgard MP, Rose-John S, Atzori M
Brain Behav Immun. 2015 Jan;43:149-58
Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury.
Godar RJ, Ma X, Liu H, Murphy JT, Weinheimer CJ, Kovacs A, Crosby SD, Saftig P, Diwan A.
Autophagy. 2015;11(9):1537-60
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease.
Rothaug M, Stroobants S, Schweizer M, Peters J, Zunke F, Allerding M, D’Hooge R, Saftig P, Blanz J.
Acta Neuropathol Commun. 2015 Jan 31;3:6
2014
GP130 activation induces myeloma and collaborates with MYC.
Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U
J Clin Invest. 2014 Dec;124(12):5263-74
Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease.
Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reißig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Münzel T
Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2658-68
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.
Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R.
EMBO J. 2014 Dec 17;33(24):2890-905
Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6.
Reif A, Siebenhaar S, Tröster A, Schmälzlein M, Lechner C, Velisetty P, Gottwald K, Pöhner C, Boos I, Schubert V, Rose-John S, Unverzagt C
Angew Chem Int Ed Engl. 2014 Nov 3;53(45):12125-31
Mycobacterium simiae infection in two unrelated patients with different forms of inherited IFN-γR2 deficiency.
Martínez- Barricarte R, Megged O, Stepensky P, Casimir P, Moncada-Velez M, Averbuch D, Assous MV, Abuzaitoun O, Kong XF, Pedergnana V, Deswarte C, Migaud M, Rose-John S, Itan Y, Boisson B, Belkadi A, Conti F, Abel L, Vogt G, Boisson-Dupuis S, Casanova JL, Bustamante J
J Clin Immunol. 2014 Nov;34(8):904-9
Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.
Effenberger T, von der Heyde J, Bartsch K, Garbers C, Schulze-Osthoff K, Chalaris A, Murphy G, Rose-John S, Rabe B
FASEB J. 2014 Nov;28(11):4847-56
Dual regulation of Fbw7 function and oncogenic transformation by Usp28.
Schülein-Völk C, Wolf E, Zhu J, Xu W, Taranets L, Hellmann A, Jänicke LA, Diefenbacher ME, Behrens A, Eilers M, Popov N.
Cell Rep. 2014 Nov 6;9(3):1099-109.
Molecular Characterization of Arylsulfatase G: Expression, Processing, Glycosylation, Transport, and Activity.
Kowalewski B, Lübke T, Kollmann K, Braulke T, Reinheckel T, Dierks T, Damme M.
J Biol Chem. 2014 Oct 3;289(40):27992-8005
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.
Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J.
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8
Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.
Madoux F, Tredup C, Spicer TP, Scampavia L, Chase PS, Hodder PS, Fields GB, Becker-Pauly C, Minond D.
Biopolymers. 2014 Sep;102(5):396-406
Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.
Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C
PLoS One. 2014 Sep 26;9(9):e107990
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.
Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF
Cell Metab. 2014 Sep 2;20(3):433-47
Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.
Quarta S, Baeumer BE, Scherbakov N, Andratsch M, Rose-John S, Dechant G, Bandtlow CE, Kress M
J Neurosci. 2014 Sep 24;34(39):13222-33
The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.
Marczynska J, Ozga A, Wlodarczyk A, Majchrzak-Gorecka M, Kulig P, Banas M, Michalczyk-Wetula D, Majewski P, Hutloff A, Schwarz J, Chalaris A, Scheller J, Rose-John S, Cichy J
J Immunol. 2014 Sep 15;193(6):2753-63
IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function.
Böttcher JP, Schanz O, Garbers C, Zaremba A, Hegenbarth S, Kurts C, Beyer M, Schultze JL, Kastenmüller W, Rose-John S, Knolle PA
Cell Rep. 2014 Sep 11;8(5):1318-27
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J
Biochim Biophys Acta. 2014 Sep;1842(9):1485-94
Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.
Chow SZ, Speck M, Yoganathan P, Nackiewicz D, Hansen AM, Ladefoged M, Rabe B, Rose-John S, Voshol PJ, Lynn FC, Herrera PL, Müller W, Ellingsgaard H, Ehses JA
Diabetes. 2014 Sep;63(9):2984-95
BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues.
Muthalagu N, Junttila MR, Wiese KE, Wolf E, Morton J, Bauer B, Evan GI, Eilers M, Murphy DJ.
Cell Rep. 2014 Sep 11;8(5):1347-53.
Microbial- induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.
Schütte A, Ermund A, Becker-Pauly C, Johansson ME, Rodriguez-Pineiro AM, Bäckhed F, Müller S, Lottaz D, Bond JS, Hansson GC.
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12396-401
Dendritic cell development requires histone deacetylase activity.
Chauvistré H, Küstermann C, Rehage N, Klisch T, Mitzka S, Felker P, Rose-John S, Zenke M, Seré KM
Eur J Immunol. 2014 Aug;44(8):2478-88
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.
Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C.
Nat Commun. 2014 Aug 21;5:4699
Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells.
Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, Schneppenheim R, Martin CL, Schröder B.
Biochem Biophys Res Commun. 2014 Aug 15;451(1):48-53
Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins.
Groot AJ, Habets R, Yahyanejad S, Hodin CM, Reiss K, Saftig P, Theys J, Vooijs M.
Mol Cell Biol. 2014 Aug;34(15):2822-32
RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.
Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N
Cardiovasc Res. 2014 Jul 15;103(2):206-16
Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.
Schlecker E, Fiegler N, Arnold A, Altevogt P, Rose-John S, Moldenhauer G, Sucker A, Paschen A, von Strandmann EP, Textor S, Cerwenka A
Cancer Res. 2014 Jul 1;74(13):3429-40
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.
Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E*, Eilers M*.
Nature. 2014 Jul 24;511(7510):483-7. *corresponding authors
Mapping orphan proteases by proteomics: Meprin metalloproteases deciphered as potential therapeutic targets.
Becker-Pauly C, Broder C, Prox J, Koudelka T, Tholey A.
Proteomics Clin Appl. 2014 Jun;8(5-6):382-8
Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR.
Science. 2014 Jun 27;344(6191):1506-10
The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).
Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J
J Biol Chem. 2014 Jun 27;289(26):18442-50
A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor.
Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J
J Biol Chem. 2014 Jun 6;289(23):16336-48
Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR.
Science. 2014 Jun 27;344(6191):1506-10
Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space.
Pruessmeyer J, Hess FM, Alert H, Groth E, Pasqualon T, Schwarz N, Nyamoya S, Kollert J, van der Vorst E, Donners M, Martin C, Uhlig S, Saftig P, Dreymueller D, Ludwig A.
Blood. 2014 Jun 26;123(26):4077-88
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.
Romi E, Gokhman I, Wong E, Antonovsky N, Ludwig A, Sagi I, Saftig P, Tessier-Lavigne M, Yaron A.
Nat Commun. 2014 Jun 5;5:4058
Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.
Baumgart S, Chen NM, Siveke JT, König A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Urrutia R, Ellenrieder V.
Cancer Discov. 2014 Jun;4(6):688-701.
Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease.
Damme M, Brandenstein L, Fehr S, Jankowiak W, Bartsch U, Schweizer M, Hermans-Borgmeyer I, Storch S.
Neurobiol Dis. 2014 May;65:12-24
LC-MS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries.
Tucher J, Linke D, Koudelka T, Cassidy L, Tredup C, Wichert R, Pietrzik C, Becker-Pauly C, Tholey A.
J Proteome Res. 2014 Apr 4;13(4):2205-14
Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3activation.
Aparicio-Siegmund S, Sommer J, Monhasery N, Schwanbeck R, Keil E, Finkenstädt D, Pfeffer K, Rose-John S, Scheller J, Garbers C
Oncotarget. 2014 Apr 30;5(8):2131-48
The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.Schneppenheim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B.
Mol Cell Biol. 2014 Apr;34(8):1398-411
IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions.
Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A
J Invest Dermatol. 2014 Mar;134(3):728-735
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells.
Kong XY*), Nesset CK*), Damme M*), Løberg EM, Lübke T, Mæhlen J, Andersson KB, Lorenzo PI, Roos N, Thoresen GH, Rustan AC, Kase ET, Eskild W.
Dis Model Mech. 2014 Mar;7(3):351-62
*) contributed equally
Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.
Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J
Biochim Biophys Acta. 2014 Feb;1843(2):275-87
Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.
Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J
J Neurosci. 2014 Feb 12;34(7):2503-13
Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.
Sanz-Moreno A, Fuhrmann D, Wolf E, von Eyss B, Eilers M, Elsässer HP.
PLoS One. 2014 Feb 19;9(2):e89187.
Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.
Acta Neuropathol. 2014;127(6):845-60
Stabilized Interleukin-6 receptor binding RNA aptamers.
Meyer C, Berg K, Eydeler-Haeder K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U
RNA Biol. 2014;11(1):57-65
Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.
Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A
J Biol Chem. 2014 Jan 31;289(5):3080-93
Oncogenic deletion mutants of gp130 signal from intracellular compartments.
Schmidt-Arras D, Müller M, Stevanovic M, Horn S, Schütt A, Bergmann J, Wilkens R, Lickert A, Rose-John S
J Cell Sci. 2014 Jan 15;127(Pt 2):341-53
"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells.
Trilling M, Le VT, Rashidi-Alavijeh J, Katschinski B, Scheller J, Rose-John S, Androsiac GE, Jonjic S, Poli V, Pfeffer K, Hengel H
J Immunol. 2014 Jan 1;192(1):447-58
T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
Dewitz C, Möller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S
FEBS J. 2014 Jan;281(1):157-74
The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction.
Müller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, Deshmukh SD, Dauth S, Brix K, Saftig P, Peters C, Henneke P, Reinheckel T.
FASEB J. 2014 Jan;28(1):162-75
Differential protein-protein interactions of full length human FasL and FasL fragments generated by proteolysis.
Lettau M*, Voss M*, Ebsen H, Kabelitz D, Janssen O.
Exp Cell Res. 2014 Jan 15;320(2):290-301
2013
Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A.
Biochim Biophys Acta. 2013 Dec;1833(12):3355-3367
ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice.
Vidal PM, Lemmens E, Avila A, Vangansewinkel T, Chalaris A, Rose-John S, Hendrix S
Cell Death Dis. 2013 Dec 12;4:e954
Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A
Biochim Biophys Acta. 2013 Dec;1833(12):3355-3367
Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
J Immunol. 2013 Dec 1;191(11):5574-82
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.
Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S.
Nature. 2013 Dec 5;504(7478):172-6
Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.
Voss M, Schröder B, Fluhrer R.
Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. Review
The role of MIZ-1 in MYC-dependent tumorigenesis.
Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M.
Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a014290.
Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10).
Weber S, Wetzel S, Prox J, Lehmann T, Schneppenheim J, Donners M, Saftig P.
Biochem Biophys Res Commun. 2013 Dec 13;442(3-4):234-41
Miz1 is required to maintain autophagic flux.
Wolf E*, Gebhardt A*, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M.
Nat Commun. 2013;4:2535. *these authors contributed equally
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3).
Möller-Hackbarth K, Dewitz C, Schweigert O, Trad A, Garbers C, Rose-John S, Scheller J
J Biol Chem. 2013 Nov 29;288(48):34529-44
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).
Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J
Cell Cycle. 2013 Nov 1;12(21):3421-32
Enzyme replacement therapy for alpha-mannosidosis: 12 months follow-up of a single centre, randomised, multiple dose study.
Borgwardt L, Dali CI, Fogh J, Månsson JE, Olsen KJ, Beck HC, Nielsen KG, Nielsen LH, Olsen SO, Riise Stensland HM, Nilssen O, Wibrand F, Thuesen AM, Pearl T, Haugsted U, Saftig P, Blanz J, Jones SA, Tylki-Szymanska A, Guffon-Fouiloux N, Beck M, Lund AM.
J Inherit Metab Dis. 2013 Nov;36(6):1015-24
Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions.
Martin P, Palmer G, Vigne S, Lamacchia C, Rodriguez E, Talabot-Ayer D, Rose-John S, Chalaris A, Gabay C
J Leukoc Biol. 2013 Oct;94(4):791-802
Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice.
Tsantikos E, Maxwell MJ, Putoczki T, Ernst M, Rose-John S, Tarlinton DM, Hibbs ML.
Arthritis Rheum. 2013 Oct;65(10):2691-702
Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets.
Marino M, Scuderi F, Ponte E, Maiuri MT, De Cristofaro R, Provenzano C, Rose-John S, Cittadini A, Bartoccioni E
J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):841-52
Epidermal ADAM17 is dispensable for notch activation.
Groot AJ, Cobzaru C, Weber S, Saftig P, Blobel CP, Kopan R, Vooijs M, Franzke CW.
J Invest Dermatol. 2013 Sep;133(9):2286-8
The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.
Kraft S, Jouvin MH, Kulkarni N, Kissing S, Morgan ES, Dvorak AM, Schröder B, Saftig P, Kinet JP.
J Immunol. 2013 Sep 15;191(6):2871-8
Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength.
Broder C, Arnold P, Vadon-Le Goff S, Konerding MA, Bahr K, Müller S, Overall CM, Bond JS, Koudelka T, Tholey A, Hulmes DJ, Moali C, Becker-Pauly C.
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14219-24
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage.
Cohnen A, Chiang SC, Stojanovic A, Schmidt H, Claus M, Saftig P, Janßen O, Cerwenka A, Bryceson YT, Watzl C.
Blood. 2013 Aug 22;122(8):1411-8
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D’Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P.
J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a
TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis.
Becker-Pauly C, Rose-John S.
EMBO Mol Med. 2013 Jul;5(7):970-2
Trp53 deficiency protects against acute intestinal inflammation.
Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.
J Immunol. 2013 Jul 15;191(2):837-47
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C.
EMBO J. 2013 Jul 17;32(14):2015-28
The intramembrane protease SPPL2A is critical for tooth enamel formation.
Bronckers AL, Gueneli N, Lüllmann-Rauch R, Schneppenheim J, Moraru AP, Himmerkus N, Bervoets TJ, Fluhrer R, Everts V, Saftig P, Schröder B.
J Bone Miner Res. 2013 Jul;28(7):1622-30
Natural history of alpha mannosidosis a longitudinal study.
Beck M, Olsen KJ, Wraith JE, Zeman J, Michalski JC, Saftig P, Fogh J, Malm D.
Orphanet J Rare Dis. 2013 Jun 20;8:88
Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles.
Schmid J, Oelbe M, Saftig P, Schwake M, Schweda F.
Pflugers Arch. 2013 Jun;465(6):895-905
An analysis of the function and expression of D6 on lymphatic endothelial cells.
McKimmie CS, Singh MD, Hewit K, Lopez-Franco O, Le Brocq M, Rose-John S, Lee KM, Baker AH, Wheat R, Blackbourn DJ, Nibbs RJ, Graham GJ
Blood. 2013 May 2;121(18):3768-77
Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice.
Braun O, Dewitz C, Möller-Hackbarth K, Scheller J, Schiffelholz T, Baier PC, Rose-John S (2013)
J Interferon Cytokine Res. 2013 May;33(5):254-60
In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli.
Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, Shriki A, Klaus S, Rosen S, Rose-John S, Galun E, Axelrod JH, Heyman SN
Clin Exp Pharmacol Physiol. 2013 Apr;40(4):262-72
Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.
Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grötzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M.
Hum Mol Genet. 2013 Apr 1;22(7):1417-23
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice.
Sina C, Lipinski S, Gavrilova O, Aden K, Rehman A, Till A, Rittger A, Podschun R, Meyer-Hoffert U, Haesler R, Midtling E, Pütsep K, McGuckin MA, Schreiber S, Saftig P*, Rosenstiel P*.
Gut. 2013 Apr;62(4):520-30 *: corresponding author
The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.
Broder C, Becker-Pauly C.
Biochem J. 2013 Mar 1;450(2):253-64
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H
J Clin Invest. 2013 Mar;123(3):1019-31
The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model.
Wei LH, Chou CH, Chen MW, Rose-John S, Kuo ML, Chen SU, Yang YS
J Clin Endocrinol Metab. 2013 Mar;98(3):E472-84
gp130 activation is regulated by D2-D3 interdomain connectivity.
Schütt A, Zacharias M, Schneider N, Horn S, Grötzinger J, Rose-John S, Schmidt-Arras D
Biochem J. 2013 Mar 15;450(3):487-96
ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.
Trad A, Hansen HP, Shomali M, Peipp M, Klausz K, Hedemann N, Yamamoto K, Mauermann A, Desel C, Lorenzen I, Lemke H, Rose-John S, Grötzinger J
Cancer Immunol Immunother. 2013 Mar;62(3):411-21
mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease.
Derer S, Till A, Haesler R, Sina C, Grabe N, Jung S, Nikolaus S, Kuehbacher T, Groetzinger J, Rose-John S, Rosenstiel PC, Schreiber S
Gut. 2013 Mar;62(3):376-86
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J.
Curr Biol. 2013 Mar 4;23(5):430-5
Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system.
Koike M, Shibata M, Ezaki J, Peters C, Saftig P, Kominami E, Uchiyama Y.
Eur J Neurosci. 2013 Mar;37(5):816-30
d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers.
Magbanua E, Zivkovic T, Hansen B, Beschorner N, Meyer C, Lorenzen I, Grötzinger J, Hauber J, Torda AE, Mayer G, Rose-John S, Hahn U
RNA Biol. 2013 Feb;10(2):216-27
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.
Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, Hölscher C, Rose-John S, Grötzinger J, Lorenzen I, Scheller J
J Biol Chem. 2013 Feb 8;288(6):4346-54
Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction.
Samavedam UK, Kalies K, Scheller J, Sadeghi H, Gupta Y, Jonkman MF, Schmidt E, Westermann J, Zillikens D, Rose-John S, Ludwig RJ
J Autoimmun. 2013 Feb;40:74-85
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C.
Cell Mol Life Sci. 2013 Jan;70(2):309-33
IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.
Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, Engel DR, Scheller J, Rose-John S, Mittrücker HW
J Immunol. 2013 Jan 15;190(2):703-11
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C
Cell Mol Life Sci. 2013 Jan;70(2):309-33
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.
Schneppenheim J, Dressel R, Hüttl S, Lüllmann-Rauch R, Engelke M, Dittmann K, Wienands J, Eskelinen EL, Hermans-Borgmeyer I, Fluhrer R, Saftig P, Schröder B.
J Exp Med. 2013 Jan 14;210(1):41-58
2012
Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.
Appelqvist H, Sandin L, Björnström K, Saftig P, Garner B, Ollinger K, Kågedal K.
PLoS One. 2012;7(11):e50262
Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.
Hönnemann J, Sanz-Moreno A, Wolf E, Eilers M, Elsässer HP.
PLoS One. 2012;7(4):e34885.
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.
Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M.
PLoS Genet. 2012;8(5):e1002728.
Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis.
Thelen M*), Damme M*), Schweizer M, Hagel C, Wong AM, Cooper JD, Braulke T, Galliciotti G.
PLoS One. 2012;7(4):e35493
*) contributed equally
Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.
Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, Rose-John S, Scheller J, Thiery J, Kratzsch J.
PLoS One. 2012;7(4):e34787
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.
Geurts N, Becker-Pauly C, Martens E, Proost P, Van den Steen PE, Stöcker W, Opdenakker G.
FEBS Lett. 2012 Dec 14;586(24):4264-9
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.
Hofmann S, Vögtle T, Bender M, Rose-John S, Nieswandt B
J Thromb Haemost. 2012 Dec;10(12):2581-92
Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon.
Arampatzidou M, Schütte A, Hansson GC, Saftig P, Brix K.
Biol Chem. 2012 Dec;393(12):1391-403
Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).
Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R.
J Biol Chem. 2012 Dec 21;287(52):43401-9
Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane.
Arolas JL, Broder C, Jefferson T, Guevara T, Sterchi EE, Bode W, Stöcker W, Becker-Pauly C, Gomis-Rüth FX.
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16131-6
Meprin α transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration.
Minder P, Bayha E, Becker-Pauly C, Sterchi EE.
JJ Biol Chem. 2012 Oct 12;287(42):35201-1
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis.
Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grötzinger J, Rose-John S, Ehlers S, Hölscher C
Immunobiology. 2012 Oct;217(10):996-1004
Activity-dependent proteolytic cleavage of neuroligin-1.
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T.
Neuron. 2012 Oct 18;76(2):410-22
Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.
Bijakowski C, Vadon-Le Goff S, Delolme F, Bourhis JM, Lécorché P, Ruggiero F, Becker-Pauly C, Yiallouros I, Stöcker W, Dive V, Hulmes DJ, Moali C.
J Biol Chem. 2012 Sep 28;287(40):33581-93
The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species.
Bien J, Jefferson T, Causević M, Jumpertz T, Munter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU.
J Biol Chem. 2012 Sep 28;287(40):33304-13
TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections.
Ohler A, Becker-Pauly C.
Biol Chem. 2012 Sep;393(9):907-14
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Kollmann K*), Damme M*), Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski JC, Käkelä R, Walkley SU, Braulke T.
Brain. 2012 Sep;135(Pt 9):2661-75
*) contributed equally
Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing.
ElSharawy A, Warner J, Olson J, Forster M, Schilhabel MB, Link DR, Rose-John S, Schreiber S, Rosenstiel P, Brayer J, Franke A
BMC Genomics. 2012 Sep 20;13:500
Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis.
Gerlach K, Daniel C, Lehr HA, Nikolaev A, Gerlach T, Atreya R, Rose-John S, Neurath MF, Weigmann B
Cancer Res. 2012 Sep 1;72(17):4340-50
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.
O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE
EMBO Mol Med. 2012 Sep;4(9):939-51
Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.
Tharmarajah G, Faas L, Reiss K, Saftig P, Young A, Van Raamsdonk CD.
Pigment Cell Melanoma Res. 2012 Sep;25(5):555-65
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, Joussen AM, Boulton ME.
EMBO Mol Med. 2012 Sep;4(9):980-91
The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.
Demirel Ö, Jan I, Wolters D, Blanz J, Saftig P, Tampé R, Abele R.
J Cell Sci. 2012 Sep 15;125(Pt 18):4230-40
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
Prox J, Willenbrock M, Weber S, Lehmann T, Schmidt-Arras D, Schwanbeck R, Saftig P, Schwake M.
Cell Mol Life Sci. 2012 Sep;69(17):2919-32
A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand β-glucocerebrosidase.
Zachos C, Blanz J, Saftig P, Schwake M.
Traffic. 2012 Aug;13(8):1113-23
A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.
Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S
Biochem J. 2012 Jul 1;445(1):135-44
Dendritic cell lineage commitment is instructed by distinct cytokine signals.
Seré KM, Lin Q, Felker P, Rehage N, Klisch T, Ortseifer I, Hieronymus T, Rose-John S, Zenke M
Eur J Cell Biol. 2012 Jun-Jul;91(6-7):515-23
Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex.
Wolf E, Kastner B, Lührmann R.
RNA. 2012 Jul;18(7):1347-57.
Long- term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection.
Mackiewicz A, Mackiewicz J, Wysocki PJ, Wiznerowicz M, Kapcinska M, Laciak M, Rose-John S, Izycki D, Burzykowski T, Karczewska-Dzionk A
Expert Opin Investig Drugs. 2012 Jun;21(6):773-83. Erratum in: Expert Opin Investig Drugs. 2012 Jul;21(7):1065.
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice.
Kowalewski B, Lamanna WC*), Lawrence R*), Damme M*), Stroobants S, Padva M, Kalus I, Frese MA, Lübke T, Lüllmann-Rauch R, D'Hooge R, Esko JD, Dierks T.
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10310-5
*) contributed equally
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.
Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, Janz S, Scheller J, Rose-John S
Blood. 2012 May 31;119(22):5173-81
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, Hu X.
Nat Immunol. 2012 May 20;13(7):642-50
The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.
Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J
FEBS Lett. 2012 Apr 24;586(8):1093-100
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J
J Biol Chem. 2012 Apr 20;287(17):13743-51
The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling.
Garcia-Oscos F, Salgado H, Hall S, Thomas F, Farmer GE, Bermeo J, Galindo LC, Ramirez RD, D'Mello S, Rose-John S, Atzori M
Biol Psychiatry. 2012 Apr 1;71(7):574-82
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.
Prox J, Rittger A, Saftig P.
Exp Brain Res. 2012 Apr;217(3-4):331-41
A designer hyper interleukin 11 (H11) is a biologically active cytokine.
Dams-Kozlowska H, Gryska K, Kwiatkowska-Borowczyk E, Izycki D, Rose-John S, Mackiewicz A
BMC Biotechnol. 2012 Mar 21;12:8
IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.
Traum D, Timothee P, Silver J, Rose-John S, Ernst M, LaRosa DF
J Leukoc Biol. 2012 Mar;91(3):427-35
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
Makrypidi G*), Damme M*), Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T.
Mol Cell Biol. 2012 Feb;32(4):774-82
*) contributed equally
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice.
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, Wollert KC, Seegert D, Rose-John S, Tietge UJ, Schieffer B, Grote K
Arterioscler Thromb Vasc Biol 2012 Feb;32(2):281-90
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T.
Mol Cell Biol. 2012 Feb;32(4):774-82
Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells.
Meyer C, Eydeler K, Magbanua E, Zivkovic T, Piganeau N, Lorenzen I, Grötzinger J, Mayer G, Rose-John S, Hahn U
RNA Biol. 2012 Jan;9(1):67-80
Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells.
Ding X, Lin Q, Ensenat-Waser R, Rose-John S, Zenke M
Stem Cells Dev. 2012 Jan;21(1):121-32
2011
Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli.
Vazeille E, Bringer MA, Gardarin A, Chambon C, Becker-Pauly C, Pender SL, Jakob C, Müller S, Lottaz D, Darfeuille-Michaud A.
PLoS One. 2011;6(6):e21199
Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer.
Lottaz D, Maurer CA, Noël A, Blacher S, Huguenin M, Nievergelt A, Niggli V, Kern A, Müller S, Seibold F, Friess H, Becker-Pauly C, Stöcker W, Sterchi EE.
PLoS One. 2011;6(11):e26450
Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S.
Biniossek ML, Nägler DK, Becker-Pauly C, Schilling O.
J Proteome Res. 2011 Dec 2;10(12):5363-73
A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36.
Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BC, Germain-Zito N, Becker-Pauly C, Ghatei MA, Bloom SR, Murphy KG.
Endocrinology. 2011 Dec;152(12):4630-40
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J
J Biol Chem 2011 Dec 16;286(50):42959-70
Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages.
Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, Hildner K, Hoffman A, Kiesslich R, Rink AD, Rau TT, Rose-John S, Kessler H, Schmidt J, Neurath MF
Gastroenterology. 2011 Dec;141(6):2026-38
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.
Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jézégou A, Reinheckel T, Hasilik A, Saftig P, Schröder B.
Biochem J. 2011 Oct 1;439(1):113-28
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS
J Clin Invest. 2011 Oct;121(10):3846-59
Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.
Behnke J, Schneppenheim J, Koch-Nolte F, Haag F, Saftig P, Schröder B.
FEBS Lett. 2011 Oct 3;585(19):2951-7
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.
van Niel G, Charrin S, Simoes S, Romao M, Rochin L, Saftig P, Marks MS, Rubinstein E, Raposo G.
Dev Cell. 2011 Oct 18;21(4):708-21
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U, Staufenbiel M.
J Neurochem. 2011 Oct;119(1):231-9
CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.
Doyle EL, Ridger V, Ferraro F, Turmaine M, Saftig P, Cutler DF.
Blood. 2011 Oct 13;118(15):4265-73
Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.Sulis ML, Saftig P, Ferrando AA.
Leukemia. 2011 Oct;25(10):1564-9
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jézégou A, Reinheckel T, Hasilik A, Saftig P, Schröder B.
Biochem J. 2011 Oct 1;439(1):113-28
Proteomicanalyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.
Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM.
Mol Cell Proteomics. 2011 Sep;10(9):M111.009233
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.
Jefferson T, Čaušević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C.
J Biol Chem. 2011 Aug 5;286(31):27741-50
Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.
Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J
Mol Biol Cell. 2010 Aug 1;21(15):2797-807. Erratum in: Mol Biol Cell. 2011 Jun;22(12):2132
Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.
Evans SF, Irmady K, Ostrow K, Kim T, Nykjaer A, Saftig P, Blobel C, Hempstead BL.
J Biol Chem. 2011 Aug 26;286(34):29556-67
Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion.
Ohler A, Becker-Pauly C.
Biol Chem. 2011 Jul;392(7):653-64
The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution.
Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):515-20
Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits.
Dauth S, Sîrbulescu RF, Jordans S, Rehders M, Avena L, Oswald J, Lerchl A, Saftig P, Brix K.
BMC Neurosci. 2011 Jul 27;12:74
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.
Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP.
Blood. 2011 Jul 28;118(4):1163-74
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method.
Agafonov DE, Deckert J, Wolf E, Odenwälder P, Bessonov S, Will CL, Urlaub H, Lührmann R.
Mol Cell Biol. 2011 Jul;31(13):2667-82.
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model.
Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH
Crit Care Med. 2011 Jun;39(6):1407-13
Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2.
Desmond MJ, Lee D, Fraser SA, Katerelos M, Gleich K, Martinello P, Li YQ, Thomas MC, Michelucci R, Cole AJ, Saftig P, Schwake M, Stapleton D, Berkovic SF, Power DA.
Am J Physiol Renal Physiol. 2011 Jun;300(6):F1437-47
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.
Cullen V, Sardi SP, Ng J, Xu YH, Sun Y, Tomlinson JJ, Kolodziej P, Kahn I, Saftig P, Woulfe J, Rochet JC, Glicksman MA, Cheng SH, Grabowski GA, Shihabuddin LS, Schlossmacher MG.
Ann Neurol. 2011 Jun;69(6):940-53
Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.
Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, Pappo O, Rose-John S, Galun E, Axelrod JH
J Hepatol. 2011 May;54(5):922-9
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.
Schiechl G, Bauer B, Fuss I, Lang SA, Moser C, Ruemmele P, Rose-John S, Neurath MF, Geissler EK, Schlitt HJ, Strober W, Fichtner-Feigl S
J Clin Invest. 2011 May;121(5):1692-708
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo.Altmeppen HC, Prox J, Puig B, Kluth MA, Bernreuther C, Thurm D, Jorissen E, Petrowitz B, Bartsch U, De Strooper B, Saftig P, Glatzel M.
Mol Neurodegener. 2011 May 27;6:36
The effect of cathepsin K deficiency on airway development and TGF-β1 degradation.
Zhang D, Leung N, Weber E, Saftig P, Brömme D.
Respir Res. 2011 May 31;12(1):72
Stat3/ Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H
Cancer Cell. 2011 Apr 12;19(4):456-69
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.
Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J
J Biol Chem. 2011 Apr 29;286(17):14804-11
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures.
Loppnow H, Zhang L, Buerke M, Lautenschläger M, Chen L, Frister A, Schlitt A, Luther T, Song N, Hofmann B, Rose-John S, Silber RE, Müller-Werdan U, Werdan K
J Cell Mol Med. 2011 Apr;15(4):994-1004
Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling.
Malchow S, Thaiss W, Jänner N, Waetzig GH, Gewiese-Rabsch J, Garbers C, Yamamoto K, Rose-John S, Scheller J
Biochim Biophys Acta. 2011 Mar;1812(3):290-301
Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis.
Loppnow H, Buerke M, Werdan K, Rose-John S
J Cell Mol Med. 2011 Mar;15(3):484-500
Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers.
Behnke J, Eskelinen EL, Saftig P, Schröder B.
Biochem J. 2011 Mar 1;434(2):219-31
β- Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current.
Huth T, Rittger A, Saftig P, Alzheimer C.
Pflugers Arch. 2011 Mar;461(3):355-71
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J.
J Neurosci. 2011 Feb 2;31(5):1837-49
Role for LAMP-2 in endosomal cholesterol transport.
Schneede A, Schmidt CK, Hölttä-Vuori M, Heeren J, Willenborg M, Blanz J, Domanskyy M, Breiden B, Brodesser S, Landgrebe J, Sandhoff K, Ikonen E, Saftig P, Eskelinen EL.
J Cell Mol Med. 2011 Feb;15(2):280-95
LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation.
Carrasco-Marín E, Fernández-Prieto L, Rodriguez-Del Rio E, Madrazo-Toca F, Reinheckel T, Saftig P, Alvarez-Dominguez C.
J Biol Chem. 2011 Feb 4;286(5):3332-41
Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α-mannosidosis.
Damme M, Stroobants S, Walkley SU, Lüllmann-Rauch R, D'Hooge R, Fogh J, Saftig P, Lübke T, Blanz J.
J Neuropathol Exp Neurol. 2011 Jan;70(1):83-94
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ
J Immunol. 2011 Jan 15;186(2):1199-208
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer.
Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, Chang JS, Lai TC, Rose-John S, Kuo ML, Wei LH
Cancer Res. 2011 Jan 15;71(2):424-34
ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.
Conrad U, Plagmann I, Malchow S, Sack M, Floss DM, Kruglov AA, Nedospasov SA, Rose-John S, Scheller J
Plant Biotechnol J. 2011 Jan;9(1):22-31
Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α-mannosidosis.
Damme M, Stroobants S, Walkley SU, Lüllmann-Rauch R, D’Hooge R, Fogh J, Saftig P, Lübke T, Blanz J.
J Neuropathol Exp Neurol. 2011 Jan;70(1):83-94
2010
Processing of procollagen III by meprins: new players in extracellular matrix assembly?
Kronenberg D, Bruns BC, Moali C, Vadon-Le Goff S, Sterchi EE, Traupe H, Böhm M, Hulmes DJ, Stöcker W, Becker-Pauly C.
J Invest Dermatol. 2010 Dec;130(12):2727-35
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S, Neurath MF(2010)
J Exp Med. 2010 Dec 20;207(13):2855-68
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA
Nat Immunol. 2010 Dec;11(12):1119-26
Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1.
Schwarz N, Pruessmeyer J, Hess FM, Dreymueller D, Pantaler E, Koelsch A, Windoffer R, Voss M, Sarabi A, Weber C, Sechi AS, Uhlig S, Ludwig A.
Cell Mol Life Sci. 2010 Dec;67(24):4233-48
3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core.
Golas MM, Sander B, Bessonov S, Grote M, Wolf E, Kastner B, Stark H, Lührmann R.
Mol Cell. 2010 Dec 22;40(6):927-38.
Role of IL-6 trans-signaling in CCl₄induced liver damage.
Gewiese-Rabsch J, Drucker C, Malchow S, Scheller J, Rose-John S
Biochim Biophys Acta. 2010 Nov;1802(11):1054-61
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.
Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R
Immunology. 2010 Nov;131(3):395-404
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.
Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP.
J Cell Sci. 2010 Nov 15;123(Pt 22):3913-22
Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases.
Hedrich J, Lottaz D, Meyer K, Yiallouros I, Jahnen-Dechent W, Stöcker W, Becker-Pauly C.
Biochemistry. 2010 Oct 5;49(39):8599-607
Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration.
Lam SP, Luk JM, Man K, Ng KT, Cheung CK, Rose-John S, Lo CM
Liver Transpl. 2010 Oct;16(10):1195-206
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B
Blood. 2010 Oct 28;116(17):3347-55
Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6
Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R
J Leukoc Biol. 2010 Sep;88(3):579-87
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J Exp Med. 2010 Aug 2;207(8):1617-24
Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.
McGreal EP, Davies PL, Powell W, Rose-John S, Spiller OB, Doull I, Jones SA, Kotecha S
Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):649-58
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S.
J Exp Med. 2010 Aug 2;207(8):1617-24
Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways.
Mendelson K, Swendeman S, Saftig P, Blobel CP.
J Biol Chem. 2010 Aug 6;285(32):25024-32
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).
Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff HJ, Lim ST.
J Biol Chem. 2010 Jul 23;285(30):22919-26
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
Shevtsova Z, Garrido M, Weishaupt J, Saftig P, Bähr M, Lühder F, Kügler S.
Am J Pathol. 2010 Jul;177(1):271-9
Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane.
Schröder B, Wrocklage C, Hasilik A, Saftig P.
Biol Chem. 2010 Jun;391(6):695-704
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx.
Horiuchi K, Le Gall S, Schulte M, Yamaguchi T, Reiss K, Murphy G, Toyama Y, Hartmann D, Saftig P, Blobel CP.
Mol Biol Cell. 2007 Jan;18(1):176-88. Erratum in: Mol Biol Cell. 2010 Jun;21(11):1908.
Molecular architecture of the human Prp19/CDC5L complex.
Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A, Fischle W, Urlaub H, Lührmann R.
Mol Cell Biol. 2010 May;30(9):2105-19.
Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation.
Ohler A, Debela M, Wagner S, Magdolen V, Becker-Pauly C.
Biol Chem. 2010 Apr;391(4):455-60
Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP).
Schröder B, Saftig P.
Biochem J. 2010 Apr 14;427(3):e1-3
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.
Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, Saftig P.
Version 2. J Neurosci. 2010 Apr 7;30(14):4833-44
The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes.
Lettau M, Pieper J, Gerneth A, Lengl-Janssen B, Voss M, Linkermann A, Schmidt H, Gelhaus C, Leippe M, Kabelitz D, Janssen O.
Protein Sci. 2010 Apr;19(4):658-69
Cathepsin K gene disruption does not affect murine aneurysm formation.
Bai L, Beckers L, Wijnands E, Lutgens SP, Herías MV, Saftig P, Daemen MJ, Cleutjens K, Lutgens E, Biessen EA, Heeneman S.
Atherosclerosis. 2010 Mar;209(1):96-103
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
J Immunol. 2010 Feb 15;184(4):2130-9
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model.
Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, Scheller J, Rose-John S, Kado S, Takada T
J Immunol. 2010 Feb 1;184(3):1543-51
ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.
Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J
Biochim Biophys Acta. 2010 Feb;1803(2):234-45
Disease- causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase.
Blanz J, Groth J, Zachos C, Wehling C, Saftig P, Schwake M.
Hum Mol Genet. 2010 Feb 15;19(4):563-72
Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.
Schütte A, Hedrich J, Stöcker W, Becker-Pauly C.
PLoS One. 2010 Jan 21;5(1):e8835
Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading.
Ambort D, Brellier F, Becker-Pauly C, Stöcker W, Andrejevic-Blant S, Chiquet M, Sterchi EE.
Matrix Biol. 2010 Jan;29(1):31-42
Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.
Damme M, Morelle W, Schmidt B, Andersson C, Fogh J, Michalski JC, Lübke T.
Mol Cell Biol. 2010 Jan;30(1):273-83
N- linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D
J Biol Chem. 2010 Jan 15;285(3):1781-9
TNF- alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.
Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Böll B, Chalaris A, Simhadri VR, Wiegmann K, Krell HW, Rose-John S, Engert A, von Strandmann EP, Hansen HP
Leukemia. 2010 Jan;24(1):51-7
Chaperone-assisted selective autophagy is essential for muscle maintenance.
Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J.
Curr Biol. 2010 Jan 26;20(2):143-8
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm.
Ha SD, Ham B, Mogridge J, Saftig P, Lin S, Kim SO.
J Biol Chem. 2010 Jan 15;285(3):2120-9
2009
Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, Tedjokusumo R, Esser K, Arzberger S, Kirschning CJ, Langenkamp A, Falk C, Büning H, Rose-John S, Protzer U
Hepatology. 2009 Dec;50(6):1773-82
G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation.
Sina C, Gavrilova O, Förster M, Till A, Derer S, Hildebrand F, Raabe B, Chalaris A, Scheller J, Rehmann A, Franke A, Ott S, Häsler R, Nikolaus S, Fölsch UR, Rose-John S, Jiang HP, Li J, Schreiber S, Rosenstiel P
J Immunol. 2009 Dec 1;183(11):7514-22
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T.
J Biol Chem. 2009 Dec 25;284(52):36024-33
Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules.
Cruz-Soto ME, Cosío G, Jeziorski MC, Vargas-Barroso V, Aguilar MB, Cárabez A, Berger P, Saftig P, Arnold E, Thebault S, Martínez de la Escalera G, Clapp C.
Endocrinology. 2009 Dec;150(12):5446-54
Klotho is a substrate for alpha-, beta- and gamma-secretase.
Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, Kuro-o M, Kaether C.
FEBS Lett. 2009 Oct 6;583(19):3221-4
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.Janes PW, Wimmer-Kleikamp SH, Frangakis AS, Treble K, Griesshaber B, Sabet O, Grabenbauer M, Ting AY, Saftig P, Bastiaens PI, Lackmann M.
PLoS Biol. 2009 Oct;7(10):e1000215
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
Voss M*, Lettau M*, Janssen O.
BMC Immunol. 2009 Oct 6;10:53
Transglutaminase-1 and bathing suit ichthyosis: molecular analysis of gene/environment interactions.
Aufenvenne K, Oji V, Walker T, Becker-Pauly C, Hennies HC, Stöcker W, Traupe H.
J Invest Dermatol. 2009 Aug;129(8):2068-71
Becker-Pauly C, Bruns BC, Damm O, Schütte A, Hammouti K, Burmester T, Stöcker W.
J Mol Biol. 2009 Jan 9;385(1):236-48
Exon, intron and splice site locations in the spliceosomal B complex.
Wolf E, Kastner B, Deckert J, Merz C, Stark H, Lührmann R.
EMBO J. 2009 Aug 5;28(15):2283-92.
NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.
Schieweck O, Damme M, Schröder B, Hasilik A, Schmidt B, Lübke T.
Biochem J. 2009 Jul 29;422(1):83-90
Transglutaminase- catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity.
Plagmann I, Chalaris A, Kruglov AA, Nedospasov S, Rosenstiel P, Rose-John S, Scheller J
J Biotechnol. 2009 Jun 15;142(2):170-8
IL-6-trans-signalling increases rapid-eye-movement sleep in rats.
May U, Schiffelholz T, Baier PC, Krueger JM, Rose-John S, Scheller J
Eur J Pharmacol. 2009 Jun 24;613(1-3):141-5
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
Baier PC, May U, Scheller J, Rose-John S, Schiffelholz T
Behav Brain Res. 2009 Jun 8;200(1):192-6
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.
Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J
J Virol. 2009 May;83(10):5117-26
Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production.
Chen L, Frister A, Wang S, Ludwig A, Behr H, Pippig S, Li B, Simm A, Hofmann B, Pilowski C, Koch S, Buerke M, Rose-John S, Werdan K, Loppnow H
Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H987-96
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.
Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B.
J Biol Chem. 2009 Apr 24;284(17):11738-47
Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1.
Kollmann K, Damme M, Deuschl F, Kahle J, D'Hooge R, Lüllmann-Rauch R, Lübke T.
FEBS J. 2009 Mar;276(5):1356-69
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha.
Le Gall SM, Bobé P, Reiss K, Horiuchi K, Niu XD, Lundell D, Gibb DR, Conrad D, Saftig P, Blobel CP.
Mol Biol Cell. 2009 Mar;20(6):1785-94
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M
Cancer Cell. 2009 Feb 3;15(2):103-13
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.
Cullen V, Lindfors M, Ng J, Paetau A, Swinton E, Kolodziej P, Boston H, Saftig P, Woulfe J, Feany MB, Myllykangas L, Schlossmacher MG, Tyynelä J.
Mol Brain. 2009 Feb 9;2:5
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.
Schröder J, Lüllmann-Rauch R, Himmerkus N, Pleines I, Nieswandt B, Orinska Z, Koch-Nolte F, Schröder B, Bleich M, Saftig P.
Mol Cell Biol. 2009 Feb;29(4):1083-94
Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function.
Huth T, Schmidt-Neuenfeldt K, Rittger A, Saftig P, Reiss K, Alzheimer C.
Neurobiol Dis. 2009 Feb;33(2):282-9
Bone density, strength, and formation in adult cathepsin K (-/-) mice.
Pennypacker B, Shea M, Liu Q, Masarachia P, Saftig P, Rodan S, Rodan G, Kimmel D.
Bone. 2009 Feb;44(2):199-207
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, Richards PJ, Slinn S, Ernst M, Jenkins BJ, Topley N, Rose-John S, Jones SA
J Immunol. 2009 Jan 1;182(1):613-22
Interleukin-6 and neural stem cells: more than gliogenesis.
Islam O, Gong X, Rose-John S, Heese K
Mol Biol Cell. 2009 Jan;20(1):188-99
Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption.
Wilson SR, Peters C, Saftig P, Brömme D.
J Biol Chem. 2009 Jan 23;284(4):2584-92
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes.
Herold N, Will CL, Wolf E, Kastner B, Urlaub H, Lührmann R.
Mol Cell Biol. 2009 Jan;29(1):281-301.
2008
Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia.
von Bismarck P, Claass A, Schickor C, Krause MF, Rose-John S
Exp Lung Res. 2008 Dec;34(10):694-706
IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier.
Linker RA, Lühder F, Kallen KJ, Lee DH, Engelhardt B, Rose-John S, Gold R
J Neuroimmunol. 2008 Dec 15;205(1-2):64-72
Posttranslational regulation of Fas ligand function.
Voss M*, Lettau M*, Paulsen M, Janssen O.
Cell Commun Signal. 2008 Dec 29;6:11
Reversal of peripheral and central neural storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice.
Blanz J, Stroobants S, Lüllmann-Rauch R, Morelle W, Lüdemann M, D’Hooge R, Reuterwall H, Michalski JC, Fogh J, Andersson C, Saftig P.
Hum Mol Genet. 2008 Nov 15;17(22):3437-45
Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130
Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J
J Biol Chem. 2008 Oct 3;283(40):27200-7
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10).
Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME.
FASEB J. 2008 Oct;22(10):3716-27
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C
J Cell Biol. 2008 Sep 8;182(5):993-1005
The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis.
Weigmann B, Lehr HA, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, Schmidt J, Galle PR, Rose-John S, Neurath MF
J Exp Med. 2008 Sep 1;205(9):2099-110
Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice.
Samokhin AO, Wong A, Saftig P, Brömme D.
Atherosclerosis. 2008 Sep;200(1):58-68
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis.
Jabs S, Quitsch A, Käkelä R, Koch B, Tyynelä J, Brade H, Glatzel M, Walkley S, Saftig P, Vanier MT, Braulke T.
J Neurochem. 2008 Aug;106(3):1415-25
ADAM10- mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.
Maretzky T, Scholz F, Köten B, Proksch E, Saftig P, Reiss K.
J Invest Dermatol. 2008 Jul;128(7):1737-46
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
Mudter J, Amoussina L, Schenk M, Yu J, Brüstle A, Weigmann B, Atreya R, Wirtz S, Becker C, Hoffman A, Atreya I, Biesterfeld S, Galle PR, Lehr HA, Rose-John S, Mueller C, Lohoff M, Neurath MF
J Clin Invest. 2008 Jul;118(7):2415-26
IL-6/IL-6R axis plays a critical role in acute kidney injury.
Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH
J Am Soc Nephrol. 2008 Jun;19(6):1106-15
Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.
Oneda B, Lods N, Lottaz D, Becker-Pauly C, Stöcker W, Pippin J, Huguenin M, Ambort D, Marti HP, Sterchi EE.
PLoS One. 2008 May 28;3(5):e2278
IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.
Marino M, Scuderi F, Provenzano C, Scheller J, Rose-John S, Bartoccioni E
J Neuroimmunol. 2008 May 30;196(1-2):41-8
Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.
Sudarman E, Bollati-Fogolín M, Hafner M, Müller W, Scheller J, Rose-John S, Eichler J
Chem Biol Drug Des. 2008 May;71(5):494-500
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel CP, Saftig P, Reiss K.
Circ Res. 2008 May 23;102(10):1192-201
IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
Walker F, Zhang HH, Matthews V, Weinstock J, Nice EC, Ernst M, Rose-John S, Burgess AW
Blood. 2008 Apr 15;111(8):3978-85
Array- based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.
Berkovic SF, Dibbens LM, Oshlack A, Silver JD, Katerelos M, Vears DF, Lüllmann-Rauch R, Blanz J, Zhang KW, Stankovich J, Kalnins RM, Dowling JP, Andermann E, Andermann F, Faldini E, D’Hooge R, Vadlamudi L, Macdonell RA, Hodgson BL, Bayly MA, Savige J, Mulley JC, Smyth GK, Power DA, Saftig P, Bahlo M.
Am J Hum Genet. 2008 Mar;82(3):673-84
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
Benrick A, Jirholt P, Wernstedt I, Gustafsson M, Scheller J, Eriksson AL, Borén J, Hedner T, Ohlsson C, Härd T, Rose-John S, Jansson JO
Regul Pept. 2008 Feb 7;146(1-3):189-96
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J
Blood. 2008 Feb 1;111(3):1021-8
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H.
Science. 2008 Feb 1;319(5863):624-7
Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice.
Beertsen W, Willenborg M, Everts V, Zirogianni A, Podschun R, Schröder B, Eskelinen EL, Saftig P. (2008)
J Immunol 180(1):475-82.
CathepsinK deficiency partially inhibits, but does not prevent, bone destructionin human tumor necrosis factor-transgenic mice.
Schurigt U, Hummel KM, Petrow PK, Gajda M, Stöckigt R, Middel P, Zwerina J, Janik T, Bernhardt R, Schüler S, Scharnweber D, Beckmann F, Saftig P, Kollias G, Schett G, Wiederanders B, Bräuer R.
Arthritis Rheum. 2008 Feb;58(2):422-34
The transcription factor repertoire of Flt3+ hematopoietic stem cells.
Hieronymus T, Ruau D, Ober-Blöbaum J, Baek JH, Rolletschek A, Rose-John S, Wobus AM, Müller AM, Zenke M
Cells Tissues Organs. 2008;188(1-2):103-15
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C.
J Biol Chem. 2008 Jan 18;283(3):1644-52
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis.
Partanen S, Haapanen A, Kielar C, Pontikis C, Alexander N, Inkinen T, Saftig P, Gillingwater TH, Cooper JD, Tyynelä J.
J Neuropathol Exp Neurol. 2008 Jan;67(1):16-29
2007
Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling.
Wei LH, Baumann H, Tracy E, Wang Y, Hutson A, Rose-John S, Henderson BW
Br J Cancer. 2007 Dec 3;97(11):1513-22
Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.
Koch M, May U, Kuhns S, Drechsler H, Adam N, Hattermann K, Wirtz S, Rose-John S, Scheller J
Biochem Biophys Res Commun. 2007 Dec 21;364(3):483-7
LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.
Reczek D, Schwake M, Schröder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P.
Cell. 2007 Nov 16;131(4):770-83
Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress.
Appenheimer MM, Girard RA, Chen Q, Wang WC, Bankert KC, Hardison J, Bain MD, Ridgley F, Sarcione EJ, Buitrago S, Kothlow S, Kaspers B, Robert J, Rose-John S, Baumann H, Evans SS
Eur J Immunol. 2007 Oct;37(10):2856-67
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.
Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones SA, Rose-John S, Scheller J
Blood. 2007 Sep 15;110(6):1748-55
Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo.
Coles B, Fielding CA, Rose-John S, Scheller J, Jones SA, O'Donnell VB
Am J Pathol. 2007 Jul;171(1):315-25. Erratum in: Am J Pathol. 2007 Sep;171(3):1078
Haematopoietic development and immunological function in the absence of cathepsin D.
Tulone C, Uchiyama Y, Novelli M, Grosvenor N, Saftig P, Chain BM.
BMC Immunol. 2007 Sep 26;8:22
Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.
Binker MG, Cosen-Binker LI, Terebiznik MR, Mallo GV, McCaw SE, Eskelinen EL, Willenborg M, Brumell JH, Saftig P, Grinstein S, Gray-Owen SD.
Cell Microbiol. 2007 Sep;9(9):2153-66
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, Yang H, Amigorena S, Ryffel B, Barrat FJ, Saftig P, Levi F, Lidereau R, Nogues C, Mira JP, Chompret A, Joulin V, Clavel-Chapelon F, Bourhis J, André F, Delaloge S, Tursz T, Kroemer G, Zitvogel L.
Nat Med. 2007 Sep;13(9):1050-9
Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells.
Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose-John S, Neurath MF, Becker C
J Immunol. 2007 Aug 15;179(4):2041-5
Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores.
Funicello M, Novelli M, Ragni M, Vottari T, Cocuzza C, Soriano-Lopez J, Chiellini C, Boschi F, Marzola P, Masiello P, Saftig P, Santini F, St-Jacques R, Desmarais S, Morin N, Mancini J, Percival MD, Pinchera A, Maffei M.
PLoS One. 2007 Aug 1;2(8):e683
Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.
Yamasaki R, Zhang J, Koshiishi I, Sastradipura Suniarti DF, Wu Z, Peters C, Schwake M, Uchiyama Y, Kira J, Saftig P, Utsumi H, Nakanishi H.
Mol Cell Neurosci. 2007 Aug;35(4):573-84
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.
Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF
Int Immunol. 2007 Jun;19(6):685-93
Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.
Hundhausen C, Schulte A, Schulz B, Andrzejewski MG, Schwarz N, von Hundelshausen P, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A.
J Immunol. 2007 Jun 15;178(12):8064-72
Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain.
Walls KC, Klocke BJ, Saftig P, Shibata M, Uchiyama Y, Roth KA, Shacka JJ.
Autophagy. 2007 May-Jun;3(3):222-9
Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio.
Schütte A, Lottaz D, Sterchi EE, Stöcker W, Becker-Pauly C.
Biol Chem. 2007 May;388(5):523-31
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation.
Becker-Pauly C, Höwel M, Walker T, Vlad A, Aufenvenne K, Oji V, Lottaz D, Sterchi EE, Debela M, Magdolen V, Traupe H, Stöcker W.
J Invest Dermatol. 2007 May;127(5):1115-25
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.
Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P.
Cell Death Differ. 2007 May;14(5):1040-9
Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy.
Schroen B, Leenders JJ, van Erk A, Bertrand AT, van Loon M, van Leeuwen RE, Kubben N, Duisters RF, Schellings MW, Janssen BJ, Debets JJ, Schwake M, Høydal MA, Heymans S, Saftig P, Pinto YM.
J Exp Med. 2007 May 14;204(5):1227-35
Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus.
Borchert N, Becker-Pauly C, Wagner A, Fischer P, Stöcker W, Brattig NW.
Microbes Infect. 2007 Apr;9(4):498-506
Self-assembly of the isolated KCNQ2 subunit interaction domain.
Wehling C, Beimgraben C, Gelhaus C, Friedrich T, Saftig P, Grötzinger J, Schwake M.
FEBS Lett. 2007 Apr 17;581(8):1594-8
Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.
Yeoh GC, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB
Hepatology. 2007 Feb;45(2):486-94
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Eichenauer DA, Simhadri VL, von Strandmann EP, Ludwig A, Matthews V, Reiners KS, von Tresckow B, Saftig P, Rose-John S, Engert A, Hansen HP
Cancer Res. 2007 Jan 1;67(1):332-8
Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells.
Chattopadhyay S, Tracy E, Liang P, Robledo O, Rose-John S, Baumann H
J Biol Chem. 2007 Feb 2;282(5):3014-26
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis.
Shacka JJ, Klocke BJ, Young C, Shibata M, Olney JW, Uchiyama Y, Saftig P, Roth KA.
J Neurosci. 2007 Feb 21;27(8):2081-90
Metalloproteases regulate T-cell proliferation and effector function via LAG-3.
Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, Hartmann D, Black RA, Rossi JJ, Blobel CP, Dempsey PJ, Workman CJ, Vignali DA.
EMBO J. 2007 Jan 24;26(2):494-504
LAMP proteins are required for fusion of lysosomes with phagosomes.
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S.
EMBO J. 2007 Jan 24;26(2):313-24
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Eichenauer DA, Simhadri VL, von Strandmann EP, Ludwig A, Matthews V, Reiners KS, von Tresckow B, Saftig P, Rose-John S, Engert A, Hansen HP.
Cancer Res. 2007 Jan 1;67(1):332-8
2006
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Weskamp G, Ford JW, Sturgill J, Martin S, Docherty AJ, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Sehara-Fujisawa A, Black RA, Ludwig A, Becherer JD, Conrad DH, Blobel CP.
Nat Immunol. 2006 Dec;7(12):1293-8
Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis.
Röcken C, Fändrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig P, Kähne T, Menard R, Ancsin JB, Bühling F.
J Pathol. 2006 Dec;210(4):478-87
Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic.
Lutgens SP, Kisters N, Lutgens E, van Haaften RI, Evelo CT, de Winther MP, Saftig P, Daemen MJ, Heeneman S, Cleutjens KB.
J Pathol. 2006 Nov;210(3):334-43
Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity.
Perez-Amodio S, Jansen DC, Schoenmaker T, Vogels IM, Reinheckel T, Hayman AR, Cox TM, Saftig P, Beertsen W, Everts V.
Calcif Tissue Int. 2006 Oct;79(4):245-54
Control of peripheral nerve myelination by the beta-secretase BACE1.
Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C.
Science. 2006 Oct 27;314(5799):664-6
Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis.
Knipper M, Claussen C, Rüttiger L, Zimmermann U, Lüllmann-Rauch R, Eskelinen EL, Schröder J, Schwake M, Saftig P.
J Physiol. 2006 Oct 1;576(Pt 1):73-86
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone.
Everts V, Korper W, Hoeben KA, Jansen ID, Bromme D, Cleutjens KB, Heeneman S, Peters C, Reinheckel T, Saftig P, Beertsen W.
J Bone Miner Res. 2006 Sep;21(9):1399-408
Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion.
Reiss K, Maretzky T, Haas IG, Schulte M, Ludwig A, Frank M, Saftig P.
J Biol Chem. 2006 Aug 4;281(31):21735-44
Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment.
Caeyenberghs K, Balschun D, Roces DP, Schwake M, Saftig P, D’Hooge R.
Neurobiol Dis. 2006 Aug;23(2):422-32
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.Bech-Serra JJ, Santiago-Josefat B, Esselens C, Saftig P, Baselga J, Arribas J, Canals F.
Mol Cell Biol. 2006 Jul;26(13):5086-95
LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling.
Stypmann J, Janssen PM, Prestle J, Engelen MA, Kögler H, Lüllmann-Rauch R, Eckardt L, von Figura K, Landgrebe J, Mleczko A, Saftig P.
Basic Res Cardiol. 2006 Jul;101(4):281-91
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
Steinfeld R, Reinhardt K, Schreiber K, Hillebrand M, Kraetzner R, Bruck W, Saftig P, Gartner J.
Am J Hum Genet. 2006 Jun;78(6):988-98
The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1.
Hintze V, Höwel M, Wermter C, Grosse Berkhoff E, Becker-Pauly C, Beermann B, Yiallouros I, Stöcker W.
Biochemistry. 2006 May 30;45(21):6741-8
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.
Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, Ullrich A.
Mol Cell Biol. 2006 May;26(10):3917-34
Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.
Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch TJ, Saftig P, Friedrich T.
J Neurosci. 2006 Apr 5;26(14):3757-66
Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth.
del Cerro-Vadillo E*, Madrazo-Toca F*, Carrasco-Marín E, Fernandez-Prieto L, Beck C, Leyva-Cobián F, Saftig P*, Alvarez-Dominguez C*.
J Immunol. 2006 Feb 1;176(3):1321-5
(* equally contributed)
Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques.
Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T.
J Mol Biol. 2006 Feb 3;355(5):1048-65.
Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation.
Lutgens E, Lutgens SP, Faber BC, Heeneman S, Gijbels MM, de Winther MP, Frederik P, van der Made I, Daugherty A, Sijbers AM, Fisher A, Long CJ, Saftig P, Black D, Daemen MJ, Cleutjens KB.
Circulation. 2006 Jan 3;113(1):98-107
2005
Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation.Willenborg M, Schmidt CK, Braun P, Landgrebe J, von Figura K, Saftig P*, Eskelinen EL*.
J Lipid Res. 2005 Dec;46(12):2559-69
(* contributed equally)
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).
Koike M, Shibata M, Waguri S, Yoshimura K, Tanida I, Kominami E, Gotow T, Peters C, von Figura K, Mizushima N, Saftig P, Uchiyama Y.
Am J Pathol. 2005 Dec;167(6):1713-28
Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2.
Eskelinen EL, Cuervo AM, Taylor MR, Nishino I, Blum JS, Dice JF, Sandoval IV, Lippincott-Schwartz J, August JT, Saftig P.
Traffic. 2005 Nov;6(11):1058-61
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.
Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K.
Mol Cell Biol. 2005 Oct;25(20):9040-53
The NH(2)-terminal transmembrane and lumenal domains of LGP85 are needed for the formation of enlarged endosomes/lysosomes.
Kuronita T, Hatano T, Furuyama A, Hirota Y, Masuyama N, Saftig P, Himeno M, Fujita H, Tanaka Y.
Traffic. 2005 Oct;6(10):895-906
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.
Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D’Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B.
J Biol Chem. 2005 Sep 2;280(35):30797-806
Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice.Shimizu T, Hayashi Y, Yamasaki R, Yamada J, Zhang J, Ukai K, Koike M, Mine K, von Figura K, Peters C, Saftig P, Fukuda T, Uchiyama Y, Nakanishi H.
J Neurochem. 2005 Aug;94(3):680-90
Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis.
D’Hooge R, Lüllmann-Rauch R, Beckers T, Balschun D, Schwake M, Reiss K, von Figura K, Saftig P.
J Neurosci. 2005 Jul 13;25(28):6539-49
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death.
González-Polo RA, Boya P, Pauleau AL, Jalil A, Larochette N, Souquère S, Eskelinen EL, Pierron G, Saftig P, Kroemer G.
J Cell Sci. 2005 Jul 15;118(Pt 14):3091-102
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.
Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P.
Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9182-7
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.
Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N.
J Biol Chem. 2005 Jun 17;280(24):23009-17
Autophagic vacuoles with sarcolemmal features delineate Danon disease and related myopathies.
Sugie K, Noguchi S, Kozuka Y, Arikawa-Hirasawa E, Tanaka M, Yan C, Saftig P, von Figura K, Hirano M, Ueno S, Nonaka I, Nishino I.
J Neuropathol Exp Neurol. 2005 Jun;64(6):513-22
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J, Schwake M.
J Neurosci. 2005 May 18;25(20):5051-60
A role for cathepsin E in the processing of mast-cell carboxypeptidase A.
Henningsson F, Yamamoto K, Saftig P, Reinheckel T, Peters C, Knight SD, Pejler G.
J Cell Sci. 2005 May 1;118(Pt 9):2035-42
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.
Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P.
EMBO J. 2005 Feb 23;24(4):742-52. Erratum in: EMBO J. 2005 May 4;24(9):1762.
2004
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C.
J Biol Chem. 2004 Dec 17;279(51):53205-12
Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice.
Kilb W, Hartmann D, Saftig P, Luhmann HJ.
Eur J Neurosci. 2004 Nov;20(10):2749-56
Cathepsin K: a cysteine protease with unique kinin-degrading properties.
Godat E, Lecaille F, Desmazes C, Duchêne S, Weidauer E, Saftig P, Brömme D, Vandier C, Lalmanach G.
Biochem J. 2004 Nov 1;383(Pt. 3):501-6
Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).
Zheng Y, Saftig P, Hartmann D, Blobel C.
J Biol Chem. 2004 Oct 8;279(41):42898-906
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W.
J Cell Biol. 2004 Sep 27;166(7):1041-54
Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study.
Roces DP, Lüllmann-Rauch R, Peng J, Balducci C, Andersson C, Tollersrud O, Fogh J, Orlacchio A, Beccari T, Saftig P, von Figura K.
Hum Mol Genet. 2004 Sep 15;13(18):1979-88
Role for Rab7 in maturation of late autophagic vacuoles.
Jäger S, Bucci C, Tanida I, Ueno T, Kominami E, Saftig P, Eskelinen EL.
J Cell Sci. 2004 Sep 15;117(Pt 20):4837-48
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells.
Wille A, Gerber A, Heimburg A, Reisenauer A, Peters C, Saftig P, Reinheckel T, Welte T, Bühling F.
Biol Chem. 2004 Jul;385(7):665-70
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, Saftig P, Craessaerts K, De Strooper B, Hartmann D.
Hum Mol Genet. 2004 Jul 1;13(13):1321-31
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts.Eskelinen EL, Schmidt CK, Neu S, Willenborg M, Fuertes G, Salvador N, Tanaka Y, Lüllmann-Rauch R, Hartmann D, Heeren J, von Figura K, Knecht E, Saftig P.
Mol Biol Cell. 2004 Jul;15(7):3132-45
Cell- matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.
Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, Nakajima M, Shinohara M, Saya H.
J Cell Biol. 2004 Jun 21;165(6):893-902
Pivotal role of cathepsin K in lung fibrosis.
Bühling F, Röcken C, Brasch F, Hartig R, Yasuda Y, Saftig P, Brömme D, Welte T.
Am J Pathol. 2004 Jun;164(6):2203-16
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A.
J Immunol. 2004 May 15;172(10):6362-72
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation.
Egberts F, Heinrich M, Jensen JM, Winoto-Morbach S, Pfeiffer S, Wickel M, Schunck M, Steude J, Saftig P, Proksch E, Schütze S.
J Cell Sci. 2004 May 1;117(Pt 11):2295-307
Cathepsin D is up-regulated in inflammatory bowel disease macrophages.
Hausmann M, Obermeier F, Schreiter K, Spottl T, Falk W, Schölmerich J, Herfarth H, Saftig P, Rogler G.
Clin Exp Immunol. 2004 Apr;136(1):157-67
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.
Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP.
J Cell Biol. 2004 Mar 1;164(5):769-79.
Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.
Kruse MN, Becker C, Lottaz D, Köhler D, Yiallouros I, Krell HW, Sterchi EE, Stöcker W.
Biochem J. 2004 Mar 1;378(Pt 2):383-9
Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).
Weskamp G, Schlöndorff J, Lum L, Becherer JD, Kim TW, Saftig P, Hartmann D, Murphy G, Blobel CP.
J Biol Chem. 2004 Feb 6;279(6):4241-9
2003
Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice.
Schellens JP, Saftig P, von Figura K, Everts V.
Cell Biol Int. 2003;27(11):897-902
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B.
J Biol Chem. 2003 Dec 5;278(49):48713-9.
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, Hundhausen C, Sadowski T, Saftig P, Hartmann D, Kallen KJ, Rose-John S.
J Biol Chem. 2003 Oct 3;278(40):38829-39
Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts.
Everts V, Hou WS, Rialland X, Tigchelaar W, Saftig P, Brömme D, Gelb BD, Beertsen W.
Calcif Tissue Int. 2003 Oct;73(4):380-6
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A.
Blood. 2003 Aug 15;102(4):1186-95
Thyroid functions of mouse cathepsins B, K, and L.
Friedrichs B, Tepel C, Reinheckel T, Deussing J, von Figura K, Herzog V, Peters C, Saftig P, Brix K.
J Clin Invest. 2003 Jun;111(11):1733-45
Differences in the activation mechanism between the alpha and beta subunits of human meprin.
Becker C, Kruse MN, Slotty KA, Köhler D, Harris JR, Rösmann S, Sterchi EE, Stöcker W.
Biol Chem. 2003 May;384(5):825-31
LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice.
Gamp AC, Tanaka Y, Lüllmann-Rauch R, Wittke D, D’Hooge R, De Deyn PP, Moser T, Maier H, Hartmann D, Reiss K, Illert AL, von Figura K, Saftig P.
Hum Mol Genet. 2003 Mar 15;12(6):631-46
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice.
Koike M, Shibata M, Ohsawa Y, Nakanishi H, Koga T, Kametaka S, Waguri S, Momoi T, Kominami E, Peters C, Figura Kv, Saftig P, Uchiyama Y.
Mol Cell Neurosci. 2003 Feb;22(2):146-61
2002
A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology.
Kuronita T, Eskelinen EL, Fujita H, Saftig P, Himeno M, Tanaka Y.
J Cell Sci. 2002 Nov 1;115(Pt 21):4117-31
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P.
Hum Mol Genet. 2002 Oct 1;11(21):2615-24
Role of LAMP-2 in lysosome biogenesis and autophagy.
Eskelinen EL, Illert AL, Tanaka Y, Schwarzmann G, Blanz J, Von Figura K, Saftig P.
Mol Biol Cell. 2002 Sep;13(9):3355-68
No endogenous A beta production in presenilin-deficient fibroblasts.
Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K, Serneels L, Annaert W, De Strooper B.
Nat Cell Biol. 2002 Jul;4(7):E164; author reply E165-6
A physiologic signaling role for the gamma-secretase-derived intracellular fragment of APP.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM.
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
Schürmann A, Koling S, Jacobs S, Saftig P, Krauss S, Wennemuth G, Kluge R, Joost HG.
Mol Cell Biol. 2002 Apr;22(8):2761-8.
Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia.
Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, Nakanishi H.
J Biol Chem. 2002 Feb 15;277(7):4816-22
Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.Zwad O, Kübler B, Roth W, Scharf JG, Saftig P, Peters C, Braulke T.
FEBS Lett. 2002 Jan 16;510(3):211-5
The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation.
Everts V, Delaissé JM, Korper W, Jansen DC, Tigchelaar-Gutter W, Saftig P, Beertsen W.
J Bone Miner Res. 2002 Jan;17(1):77-90
2001
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice.Suter A, Everts V, Boyde A, Jones SJ, Lüllmann-Rauch R, Hartmann D, Hayman AR, Cox TM, Evans MJ, Meister T, von Figura K, Saftig P.
Development. 2001 Dec;128(23):4899-910
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, De Strooper B, Grassi J, Lopez-Perez E, Checler F.
J Biol Chem. 2001 Oct 12;276(41):37743-6
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.Nakanishi H, Zhang J, Koike M, Nishioku T, Okamoto Y, Kominami E, von Figura K, Peters C, Yamamoto K, Saftig P, Uchiyama Y.
J Neurosci. 2001 Oct 1;21(19):7526-33
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W.
J Cell Biol. 2001 Aug 20;154(4):731-40
Biosynthesis of phosphatidylcholine from a phosphocholine precursor pool derived from the late endosomal/lysosomal degradation of sphingomyelin.
Jansen SM, Groener JE, Bax W, Suter A, Saftig P, Somerharju P, Poorthuis BJ.
J Biol Chem. 2001 Jun 1;276(22):18722-7
2000
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.
Roth W, Deussing J, Botchkarev VA, Pauly-Evers M, Saftig P, Hafner A, Schmidt P, Schmahl W, Scherer J, Anton-Lamprecht I, Von Figura K, Paus R, Peters C.
FASEB J. 2000 Oct;14(13):2075-86
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.
Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E, Peters C, von Figura K, Uchiyama Y.
J Neurosci. 2000 Sep 15;20(18):6898-906
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.
Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lüllmann-Rauch R, Janssen PM, Blanz J, von Figura K, Saftig P.
Nature. 2000 Aug 24;406(6798):902-6
Spermatogenesis proceeds normally in mice without linker histone H1t.
Drabent B, Saftig P, Bode C, Doenecke D.
Histochem Cell Biol. 2000 Jun;113(6):433-42
mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors.
Meyer C, Zizioli D, Lausmann S, Eskelinen EL, Hamann J, Saftig P, von Figura K, Schu P.
EMBO J. 2000 May 15;19(10):2193-203
1999
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM.
J Biol Chem. 1999 Dec 17;274(51):36801-7
Cathepsin D targeted by acid sphingomyelinase-derived ceramide.
Heinrich M, Wickel M, Schneider-Brachert W, Sandberg C, Gahr J, Schwandner R, Weber T, Saftig P, Peters C, Brunner J, Krönke M, Schütze S.
EMBO J. 1999 Oct 1;18(19):5252-63. Erratum in: EMBO J 2000 Jan 17;19(2):315.
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B.
Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7
Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis.
Stinchi S, Lüllmann-Rauch R, Hartmann D, Coenen R, Beccari T, Orlacchio A, von Figura K, Saftig P.
Hum Mol Genet. 1999 Aug;8(8):1365-72
Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly.
Hartmann D, De Strooper B, Saftig P.
Curr Biol. 1999 Jul 15;9(14):719-27
Normal lysosomal morphology and function in LAMP-1-deficient mice.
Andrejewski N, Punnonen EL, Guhde G, Tanaka Y, Lüllmann-Rauch R, Hartmann D, von Figura K, Saftig P.
J Biol Chem. 1999 Apr 30;274(18):12692-701
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R.
Nature. 1999 Apr 8;398(6727):518-22
Early embryonic death of mice deficient in gamma-adaptin.
Zizioli D, Meyer C, Guhde G, Saftig P, von Figura K, Schu P.
J Biol Chem. 1999 Feb 26;274(9):5385-90
1998
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.
Saftig P, Hunziker E, Wehmeyer O, Jones S, Boyde A, Rommerskirch W, Moritz JD, Schu P, von Figura K.
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13453-8
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA.
Nature. 1998 Oct 15;395(6703):698-702
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
Wu GS, Saftig P, Peters C, El-Deiry WS.
Oncogene. 1998 Apr 30;16(17):2177-83
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.
Deussing J, Roth W, Saftig P, Peters C, Ploegh HL, Villadangos JA.
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4516-21
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F.
Nature. 1998 Jan 22;391(6665):387-90
1997
Non- conventional role of lysosomal acid phosphatase in olfactory receptor axons: co-localization with growth-associated phosphoprotein-43.
Wolff JR, Liu WL, Böttcher H, Krizbai I, Jóo F, Saftig P, Parducz Á.
Neuroscience. 1997 Aug;79(3):887-91
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.
Saftig P, Hartmann D, Lüllmann-Rauch R, Wolff J, Evers M, Köster A, Hetman M, von Figura K, Peters C.
J Biol Chem. 1997 Jul 25;272(30):18628-35
1996
Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy.
Hess B, Saftig P, Hartmann D, Coenen R, Lüllmann-Rauch R, Goebel HH, Evers M, von Figura K, D’Hooge R, Nagels G, De Deyn P, Peters C, Gieselmann V.
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14821-6
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.
Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B.
J Biol Chem. 1996 Nov 1;271(44):27241-4
Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI.
Evers M, Saftig P, Schmidt P, Hafner A, McLoghlin DB, Schmahl W, Hess B, von Figura K, Peters C.
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8214-9
1995
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
Saftig P, Hetman M, Schmahl W, Weber K, Heine L, Mossmann H, Köster A, Hess B, Evers M, von Figura K, et al.
EMBO J. 1995 Aug 1;14(15):3599-608
1994
Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.
Hetman M, Perschl A, Saftig P, Von Figura K, Peters C.
DNA Cell Biol. 1994 Apr;13(4):419-27
1993
Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.
Köster A, Saftig P, Matzner U, von Figura K, Peters C, Pohlmann R.
EMBO J. 1993 Dec 15;12(13):5219-23