Christoph Becker-Pauly is spokesperson of the DFG-funded Research Training Group ReMPro and has published over 100 research papers on the structure and function of proteolytic enzymes in health and disease. Proteases are considered central nodes in the regulation of the immune system, in neurodegeneration, and in cancer. Among the nearly 600 human proteases, his group is particularly interested in the characterization of metalloproteases, especially meprins, ADAM10/17, and MMPs. Using N-terminomics, cell culture, and mouse models, his group has discovered important biological functions of these enzymes in mucosal homeostasis, Alzheimer's disease, tumor progression, and systemic and local inflammatory diseases.