July 2025
We are delighted to be among the recipients of the 2025 ERC Proof of Concept Grants! With DEGRON, we aim to explore the commercial potential of our PROTAC assay platform.Many thanks to the European Research Council
for their support. (Press Release of the CAU)
May 2025
We are thrilled about CAU’s success in the Cluster Initiative and our involvement in the “Precision Medicine in Chronic Inflammation” (PMI) cluster. Many thanks to the speaker team and everyone involved!
News
April 2025
Great collaboration and impressive application of the RiPa assay! The Müller lab demonstrates in a Nature Chemical Biology publication that induced proximity between the SUMO ligase PML and the protein TDP-43 inhibits its aggregation. Congratulations!
January 2025
Our work on SCAF1 as an activator for RNAPII elongation is online at Nucleic Acids Research! https://doi.org/10.1093/nar/gkae1219
Our new manuscript has been published in eLife. We describe a new method for identifying suitable E3 ligases for PROTACs. Many thanks to everyone involved.
December 2024
November 2024
- Our new paper on TTK/Aurora PROTACs is out. Great collaboration with the Sarli lab. Thanks to all involved!
- Congratulations to Markus Vogt on successfully defending his PhD!
- We are happy to welcome three new lab members and wish them a good start - Tonja for her MD thesis and Dana and Rose for their PhD studies!
October 2024
We congratulate Michaela Reissland and the whole team in Markus Diefenbacher's lab on their new paper in Oncogene. In the study, they were able to demonstrate the role of USP10 in Wnt signalling in colorectal cancer models. Thank you for the opportunity to contribute to this interesting study. See the paper here.
July 2025
- Our paper about Targeting MYC via RUVBL1/2 in PDAC is now online. Congratulations, Markus and Nevenka! You can find it here: https://gut.bmj.com/content/early/2024/05/31/gutjnl-2023-331519
- A new PhD student joined our team - Welcome Jan Philipp!
January 2026
New paper from the Wolf lab in the Journal of Medicinal Chemistry describing optimized degrader compounds (PROTACs) targeting the oncogenic kinase AURORA A. This work represents a great collaborative effort with Lindsay Evans, Gary Newton, Jack O’Hanlon, and many others at the ICR.