Meprin β elevates hippocampal soluble Aβ in the APP/V717I mouse model. 

Keller M, Gallagher C, Marengo L, Bickenbach K, Schmitt U, Abukhalaf M, Tholey A, Kreiselmaier S, Becker-Pauly C,  Mittmann T, Pietrzik CU.Exp Neurol. 2026 Mar;397:115600. doi: 10.1016/j.expneurol.2025.115600. Epub 2025 Dec 19.

Regulation of keratinocyte proliferation and epidermal inflammation by meprin α-mediated cleavage of dermokine. 

Köhling V, Peters F, Götting I, Fries E, Beck N, Armbrust F, Beckinger S, Bülck C, Canbay V, Harder I, Mengel M, Rüffer M, Bickenbach K, Kalogeropoulos K, Schweizer M, Lewerenz M, Schumacher N, Jonca N, Haase M, Naumann R, Auf dem Keller U, Becker-Pauly C, Rüffer S. J Invest Dermatol. 2026 Feb 10:S0022-202X(26)00084-9. doi: 10.1016/j.jid.2026.01.034. Online ahead of print.

Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinoma. 

Peng J, Yang J, Antonopoulou G, Fang R, Adhikari B, Vogt M, Wolf E, Sun C, Du S, Godfrey L, Gupta A, Trajkovic-Arsic M, Teichmann N, Grünwald BT, Krebs N, Steiger K, Mogler C, Althoff K, Wang X, Giglio G, Liffers ST, Savvatakis K, Braren R, Lawlor RT, Scarpa A, Behrens D, Lang KS, Cheung PF, Siveke JT. Nat Commun. 2026 Feb 6. doi: 10.1038/s41467-026-69013-y. Online ahead of print.

Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery. 

Mitrović M, Greco FA, García YC, Lučić A, Hoffmann L, Chander R, Schönfeld J, Liebisch N, Sivashanmugam SA, Schwalm MP, Egner M, Lewandowski M, Merk D, Morasch V, Wolf E, Müller S, Hanke T, Proschak E, Hiesinger K, Knapp S. J Med Chem. 2026 Jan 23. doi: 10.1021/acs.jmedchem.5c02543. Online ahead of print. PMID: 41575171

Unhooking the Hook: Optimization of the Aurora A Targeting PROTAC JB170 to CCT400028, an In Vitro Degrader Chemical Probe. 

O'Hanlon JA, Gutsche K, Müller JE, Ranjan Prusty N, Mirza A, Roumeliotis TI, Yang H, Stubbs M, Hallett ST, Eing L, McAndrew PC, Choudhary JS, Le Bihan YV, Caldwell J, van Montfort RLM, Workman P, Wolf E*, Newton GK*, Evans LE*

J Med Chem. 2026 Jan 12. doi: 10.1021/acs.jmedchem.5c03024. Online ahead of print.

Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease. 

Lahme K, Sachs W, Froembling S, Loreth D, Böttcher-Dierks V, Neumann K, Hann FM, Arkan N, Brehler M, Reichelt J, Sgries A, Surmann K, Gaffling S, Adler MR, Sáez PJ, Wedekind U, Lampert A, Tasika E, Saftig P, Conze C, Thünauer R, Skuza S, Neitzel K, Zielinski S, Brand J, Bonn S, Michalik S, Völker U, Zimmermann M, Wiech T, Meyer TN, Fester L, Meyer-Schwesinger C. Cell. 2026 Jan 8;189(1):123-142.e30. doi: 10.1016/j.cell.2025.11.010. Epub 2025 Dec 4.