Research in the Voss lab aims to elucidate how proteolytic processing of glycosylation enzymes in the Golgi apparatus contributes to or is interconnected with the overall organisation of the Golgi. Combining tailored engineered cell culture models, protein biochemistry and cell biology tools as well as state-of-the-art proteomics, the lab studies in particular the intramembrane protease SPPL3, which has emerged as a potent physiological regulator of glycosylation.