Research Unit
Lysosomal Diseases and Characterization of New Lysosomal (Membrane) Proteins
Publications
2025
Roles of lysosomal small-molecule transporters in metabolism and signaling.
Trends Cell Biol. 2025 Oct 17:S0962-8924(25)00222-3.
LIMP-2 deficiency-associated glycolipid abnormalities in mice.
Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Oct;1870(7):159657.
Bi-allelic LAMP3 variants in childhood interstitial lung disease: a surfactant-related disease.
EBioMedicine. 2025 Mar;113:105626.
Physiological shedding and C-terminal proteolytic processing of TMEM106B.
Held S, Erck C, Kemppainen S, Bleibaum F, Giridhar NJ, Feederle R, Krenner C, Juopperi SP, Calliari A, Mentrup T, Schröder B, Dickson DW, Rauramaa T, Petrucelli L, Prudencio M, Hiltunen M, Lüningschrör P, Capell A, Damme M.
Cell Rep. 2025 Jan 28;44(1):115107.
Expanding the genetic landscape of Usher syndrome type IV caused by pathogenic ARSG variants.
Bauwens M, De Man V, Audo I, Balikova I, Zein WM, Smirnov V, Held S, Vermeer S, Loos E, Jacob J, Casteels I, Désir J, Depasse F, Van de Sompele S, Van Heetvelde M, De Bruyne M, Andrieu C, Condroyer C, Antonio A, Hufnagel R, Carvalho AL, Marques JP, Zeitz C, De Baere E, Damme M.
Clin Genet. 2025 Jan;107(1):44-55.
By Year
Other
2024
Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy.
Hutchings AJ, Hambrecht B, Veh A, Giridhar NJ, Zare A, Angerer C, Ohnesorge T, Schenke M, Selvaraj BT, Chandran S, Sterneckert J, Petri S, Seeger B, Briese M, Stigloher C, Bischler T, Hermann A, Damme M, Sendtner M, Lüningschrör.
P. Nat Commun. 2024 Oct 4;15(1):8622.
Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown.
Daumke O, Damme M.
Structure. 2024 Jun 6;32(6):645-647.
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.
Song F, Kovac V, Mohammadi B, Littau JL, Scharfenberg F, Matamoros Angles A, Vanni I, Shafiq M, Orge L, Galliciotti G, Djakkani S, Linsenmeier L, Černilec M, Hartman K, Jung S, Tatzelt J, Neumann JE, Damme M, Tschirner SK, Lichtenthaler SF, Ricklefs FL, Sauvigny T, Schmitz M, Zerr I, Puig B, Tolosa E, Ferrer I, Magnus T, Rupnik MS, Sepulveda-Falla D, Matschke J, Šmid LM, Bresjanac M, Andreoletti O, Krasemann S, Foliaki ST, Nonno R, Becker-Pauly C, Monzo C, Crozet C, Haigh CL, Glatzel M, Curin Serbec V, Altmeppen HC.
Acta Neuropathol. 2024 Jul 9;148(1):2.
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes.
Jungnickel KEJ, Guelle O, Iguchi M, Dong W, Kotov V, Gabriel F, Debacker C, Dairou J, McCort-Tranchepain I, Laqtom NN, Chan SH, Ejima A, Sato K, Massa López D, Saftig P, Mehdipour AR, Abu-Remaileh M, Gasnier B, Löw C, Damme M.
Nat Cell Biol. 2024 Jul;26(7):1047-1061.
Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis.
Gallwitz L, Bleibaum F, Voss M, Schweizer M, Spengler K, Winter D, Zöphel F, Müller S, Lichtenthaler S, Damme M, Saftig P.
Cell Mol Life Sci. 2024 May 22;81(1):227.
Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Roske Y, Cappel C, Cremer N, Hoffmann P, Koudelka T, Tholey A, Heinemann U, Daumke O, Damme M.
Nucleic Acids Res. 2024 Jan 11;52(1):370-384.
2023
Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism.
Van Acker ZP, Perdok A, Hellemans R, North K, Vorsters I, Cappel C, Dehairs J, Swinnen JV, Sannerud R, Bretou M, Damme M, Annaert W.
Nat Commun. 2023 May 24;14(1):2847.
Multi Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins.
Akter F, Bonini S, Ponnaiyan S, Kögler-Mohrbacher B, Bleibaum F, Damme M, Renard BY, Winter D.
Mol Cell Proteomics. 2023 Mar;22(3):100509.
Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.
Cabron AS, Borgmeyer U, Richter J, Peisker H, Gutbrod K, Dörmann P, Capell A, Damme M.
Acta Neuropathol Commun. 2023 Jan 27;11(1):21.
2022
The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis.
Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE.
Front Oncol. 2022 Feb 8;12:777634
Usher syndrome type IV: clinically and molecularly confirmed by novel ARSG variants.
Velde HM, Reurink J, Held S, Li CHZ, Yzer S, Oostrik J, Weeda J, Haer-Wigman L, Yntema HG, Roosing S, Pauleikhoff L, Lange C, Whelan L, Dockery A, Zhu J, Keegan DJ, Farrar GJ, Kremer H, Lanting CP, Damme M, Pennings RJE.
Hum Genet. 2022 Nov;141(11):1723-1738.
BCAS3-Related Neurodevelopmental Disorder Shows Magnetic Resonance Imaging Features Resembling Brain Iron Accumulation.
Wong WK, Troedson C, Damme M, Goetti R, Temple SEL, Schöls L, Balousha G, Prelog K, Buckley M, Roscioli T, Hengel H, Mohammad SS.
Mov Disord. 2022 Apr;37(4):870-872
2021
AMPylation profiling during neuronal differentiation reveals extensive variation on lysosomal proteins.
Becker T, Cappel C, Di Matteo F, Sonsalla G, Kaminska E, Spada F, Cappello S, Damme M, Kielkowski P.
iScience. 2021 Nov 26;24(12):103521
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.
Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bär J, Shrivastava AN, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, Mazzola F, Varani L, Thapa S, Gilch S, Schätzl H, Harris DA, Triller A, Mikhaylova M, Aguzzi A, Altmeppen HC, Glatzel M.
Sci Adv. 2021 Nov 26;7(48)
CLN6 deficiency causes selective changes in the lysosomal protein composition.
Tuermer A, Mausbach S, Kaade E, Damme M, Sylvester M, Gieselmann V, Thelen M.
Proteomics. 2021 Oct;21(19):e2100043.
Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG).
Kowalewski B, Lange H, Galle S, Dierks T, Lübke T, Damme M.
Biochem J. 2021 Aug 18:BCJ20210415.
S-Palmitoylation determines TMEM55B-dependent positioning of lysosomes.
Rudnik S, Heybrock S, Saftig P, Damme M.
2022 Mar 1;135(5):jcs258566
LAMP3 deficiency affects surfactant homeostasis in mice.
Lunding LP, Krause D, Stichtenoth G, Stamme C, Lauterbach N, Hegermann J, Ochs M, Schuster B, Sedlacek R, Saftig P, Schwudke D, Wegmann M, Damme M.
PLoS Genet. 2021 Jun 23;17(6):e1009619.
New clinical and molecular evidence linking mutations in ARSG to Usher syndrome type IV.
Peter VG, Quinodoz M, Sadio S, Held S, Rodrigues M, Soares M, Sousa AB, Coutinho Santos L, Damme M, Rivolta C.
Hum Mutat. 2021 Mar;42(3):261-271
Quantification and characterization of the 5'exonuclease activity of the lysosomal nuclease PLD3 by a novel cell-based assay.
Cappel C, Gonzalez AC, Damme M.
J Biol Chem. Jan-Jun 2021;296:100152
Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction.
Stroobants S, D'Hooge R, Damme M.
Brain Pathol. 2021 Mar;31(2):223-238.
2020
Characterization of the complex of the lysosomal membrane transporter MFSD1 and its accessory subunit GLMP.
Massa López D, Kählau L, Jungnickel KEJ, Löw C, Damme M.
FASEB J. 2020 Nov;34(11):14695-14709
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A.
EMBO Rep. 2020 Oct 5;21(10):e50241
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Marques ARA, Di Spiezio A, Thießen N, Schmidt L, Grötzinger J, Lüllmann-Rauch R, Damme M, Storck SE, Pietrzik CU, Fogh J, Bär J, Mikhaylova M, Glatzel M, Bassal M, Bartsch U, Saftig P.
Autophagy. 2020 May;16(5):811-825
The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M.
Cell Rep. 2020 Mar 10;30(10):3506-3519.e6
2019
The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP.
Massa López D, Thelen M, Stahl F, Thiel C, Linhorst A, Sylvester M, Hermanns-Borgmeyer I, Lüllmann-Rauch R, Eskild W, Saftig P, Damme M.
Elife. 2019 Oct 29;8
Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.
Moreau D, Vacca F, Vossio S, Scott C, Colaco A, Paz Montoya J, Ferguson C, Damme M, Moniatte M, Parton RG, Platt FM, Gruenberg J.
EMBO Rep. 2019 Jul;20(7):e47055
A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five.
Khundadze M, Ribaudo F, Hussain A, Rosentreter J, Nietzsche S, Thelen M, Winter D, Hoffmann B, Afzal MA, Hermann T, de Heus C, Piskor EM, Kosan C, Franzka P, von Kleist L, Stauber T, Klumperman J, Damme M, Proikas-Cezanne T, Hübner CA.
Neurobiol Dis. 2019 Jul;127:419-431
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Reinicke AT, Laban K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch PC, Duncan KE, Saftig P, Rinschen MM, Morellini F, Meyer-Schwesinger C.
Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7963-7972
2018
PLD3 and spinocerebellar ataxia.
Gonzalez AC, Stroobants S, Reisdorf P, Gavin AL, Nemazee D, Schwudke D, D'Hooge R, Saftig P, Damme M.
Brain. 2018 Nov 1;141(11):e78.
A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans.
Khateb S, Kowalewski B, Bedoni N, Damme M, Pollack N, Saada A, Obolensky A, Ben-Yosef T, Gross M, Dierks T, Banin E, Rivolta C, Sharon D.
Genet Med. 2018 Sep;20(9):1004-1012
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.
Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D.
Nat Immunol. 2018 Sep;19(9):942-953
Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome.
De Pace R, Skirzewski M, Damme M, Mattera R, Mercurio J, Foster AM, Cuitino L, Jarnik M, Hoffmann V, Morris HD, Han TU, Mancini GMS, Buonanno A, Bonifacino JS.
PLoS Genet. 2018 Apr 26;14(4):e1007363
RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.
Bartsch K, Damme M, Regen T, Becker L, Garrett L, Hölter SM, Knittler K, Borowski C, Waisman A, Glatzel M, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rabe B.
Front Immunol. 2018 Mar 29;9:587
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.
Gonzalez AC, Schweizer M, Jagdmann S, Bernreuther C, Reinheckel T, Saftig P, Damme M.
Cell Rep. 2018 Jan 23;22(4):1040-1053
2017
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, Maystadt I, Füchtbauer A, Füchtbauer EM, Jablonka S, Blum R, Üçeyler N, Petri S, Kaltschmidt B, Jahn R, Kaltschmidt C, Sendtner M.
Nat Commun. 2017 Oct 30;8(1):678
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.
Bartsch K, Knittler K, Borowski C, Rudnik S, Damme M, Aden K, Spehlmann ME, Frey N, Saftig P, Chalaris A, Rabe B.
Hum Mol Genet. 2017 Oct 15;26(20):3960-3972
Long- term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R.
Neurobiol Dis. 2017 Oct;106:255-268
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, Saftig P, Van Damme P.
Hum Mol Genet. 2017 Aug 1;26(15):2850-2863
Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes.
Kissing S, Rudnik S, Damme M, Lüllmann-Rauch R, Ichihara A, Kornak U, Eskelinen EL, Jabs S, Heeren J, De Brabander JK, Haas A, Saftig P.
Mol Cell Proteomics. 2017 Mar;16(3):438-450
Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II.
Markmann S, Krambeck S, Hughes CJ, Mirzaian M, Aerts JM, Saftig P, Schweizer M, Vissers JP, Braulke T, Damme M.
Mol Cell Proteomics. 2017 Mar;16(3):438-450
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P.
Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):217-230
2016
A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease.
Wolf H, Damme M, Stroobants S, D'Hooge R, Beck HC, Hermans-Borgmeyer I, Lüllmann-Rauch R, Dierks T, Lübke T.
Dis Model Mech. 2016 Sep 1;9(9):1015-28
Age-dependent development of liver fibrosis in Glmpgt/gt mice.
Cecilie K. Nesset, Xiang Yi Kong, Markus Damme, Camilla Schjalm, Norbert Roos, Else Marit Løberg and Winnie Eskild.
Fibrogenesis Tissue Repair. 2016 Apr 28;9:5
Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice.
Kruszewski K, Lüllmann-Rauch R, Dierks T, Bartsch U, Damme M.
nvest Ophthalmol Vis Sci. 2016 Mar;57(3):1120-31
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Klionsky DJ, ..., Damme M, ..., Zughaier SM.
Autophagy. 2016 Jan 2;12(1):1-222.
2015
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.
Blanz J, Zunke F, Markmann S, Damme M, Braulke T, Saftig P, Schwake M.
Traffic. 2015 Oct;16(10):1127-36
Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice.
Damme M, Stroobants S, Lüdemann M, Rothaug M, Lüllmann-Rauch R, Beck HC, Ericsson A, Andersson C, Fogh J, D'Hooge R, Saftig P, Blanz J.
Ann Clin Transl Neurol. 2015 Sep 19;2(11):987-1001
In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11.
Varga RE, Khundadze M, Damme M, Nietzsche S, Hoffmann B, Stauber T, Koch N, Hennings JC, Franzka P, Huebner AK, Kessels MM, Biskup C, Jentsch TJ, Qualmann B, Braulke T, Kurth I, Beetz C, Hübner CA.
PLoS Genet. 2015 Aug 18;11(8):e1005454
Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver.
Kong XY, Kase ET, Herskedal A, Schjalm C, Damme M, Nesset CK, Thoresen GH, Rustan AC, Eskild W.
PLoS One. 2015 Jun 5;10(6):e0129402
Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III).
Kowalewski B, Heimann P, Ortkras T, Lüllmann-Rauch R, Sawada T, Walkley SU, Dierks T, Damme M.
Hum Mol Genet. 2015 Apr 1;24(7):1856-68
Review: Autophagy in neuronal cells: general principles and physiological and pathological functions.
Damme M, Suntio T, Saftig P, Eskelinen EL.
Acta Neuropathol. 2015 Mar;129(3):337-62
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease.
Peters J, Rittger A, Weisner R, Knabbe J, Zunke F, Rothaug M, Damme M, Berkovic SF, Blanz J, Saftig P, Schwake M.
Biochem Biophys Res Commun. 2015 Feb 13;457(3):334-40
2014
Molecular Characterization of Arylsulfatase G: Expression, Processing, Glycosylation, Transport, and Activity.
Kowalewski B, Lübke T, Kollmann K, Braulke T, Reinheckel T, Dierks T, Damme M.
J Biol Chem. 2014 Oct 3;289(40):27992-8005
Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR.
Science. 2014 Jun 27;344(6191):1506-10
Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.
Acta Neuropathol. 2014;127(6):845-60
Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease.
Damme M, Brandenstein L, Fehr S, Jankowiak W, Bartsch U, Schweizer M, Hermans-Borgmeyer I, Storch S.
Neurobiol Dis. 2014 May;65:12-24
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells.
Kong XY*), Nesset CK*), Damme M*), Løberg EM, Lübke T, Mæhlen J, Andersson KB, Lorenzo PI, Roos N, Thoresen GH, Rustan AC, Kase ET, Eskild W.
Dis Model Mech. 2014 Mar;7(3):351-62
*) contributed equally
2012
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Kollmann K*), Damme M*), Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski JC, Käkelä R, Walkley SU, Braulke T.
Brain. 2012 Sep;135(Pt 9):2661-75
*) contributed equally
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice.
Kowalewski B, Lamanna WC*), Lawrence R*), Damme M*), Stroobants S, Padva M, Kalus I, Frese MA, Lübke T, Lüllmann-Rauch R, D'Hooge R, Esko JD, Dierks T.
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10310-5
*) contributed equally
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
Makrypidi G*), Damme M*), Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T.
Mol Cell Biol. 2012 Feb;32(4):774-82
*) contributed equally
Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis.
Thelen M*), Damme M*), Schweizer M, Hagel C, Wong AM, Cooper JD, Braulke T, Galliciotti G.
PLoS One. 2012;7(4):e35493
*) contributed equally
2011
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.
Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jézégou A, Reinheckel T, Hasilik A, Saftig P, Schröder B.
Biochem J. 2011 Oct 1;439(1):113-28
Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α-mannosidosis.
Damme M, Stroobants S, Walkley SU, Lüllmann-Rauch R, D'Hooge R, Fogh J, Saftig P, Lübke T, Blanz J.
J Neuropathol Exp Neurol. 2011 Jan;70(1):83-94
2010
Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.
Damme M, Morelle W, Schmidt B, Andersson C, Fogh J, Michalski JC, Lübke T.
Mol Cell Biol. 2010 Jan;30(1):273-83
2009
NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.
Schieweck O, Damme M, Schröder B, Hasilik A, Schmidt B, Lübke T.
Biochem J. 2009 Jul 29;422(1):83-90
Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1.
Kollmann K, Damme M, Deuschl F, Kahle J, D'Hooge R, Lüllmann-Rauch R, Lübke T.
FEBS J. 2009 Mar;276(5):1356-69
2023
Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein.
Mohammadi B, Song F, Matamoros-Angles A, Shafiq M, Damme M, Puig B, Glatzel M, Altmeppen HC.
Cell Tissue Res. 2023 Apr;392(1):215-234.
Reviews
2021
The lysosomal membrane - export of metabolites and beyond.
Rudnik, S, Damme M.
FEBS J. 2021 Jul;288(14):4168-4182.
2020
Lysosomal sulfatases: a growing family.
Lübke T, Damme M.
Biochem J. 2020 Oct 30;477(20):3963-3983.