Research Unit
Tumor Biochemistry
Prof. Dr. Elmar Wolf
Tel. +49 431 880-3336
Elmar Wolf is a tumor biologist whose research focuses on oncogenic transcription factors and strategies to therapeutically target them. In collaboration with medicinal chemistry partners, he pursues the approach of directing tumorigenic proteins toward proteasomal degradation using PROTACs (proteolysis-targeting chimeras). These small molecules are not only powerful cell biological tools but also represent an entirely novel and unique therapeutic strategy. Elmar develops PROTACs within projects funded by the ERC (Starting, Consolidator, and Proof of Concept Grants), the German Cancer Aid (consortium project TACTIC), and the DFG (Collaborative Research Center 387).
Publications
By Year
2026
Nat Commun. 2026 Feb 6. doi: 10.1038/s41467-026-69013-y. Online ahead of print.
Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery.
J Med Chem. 2026 Jan 23. doi: 10.1021/acs.jmedchem.5c02543. Online ahead of print. PMID: 41575171
J Med Chem. 2026 Jan 12. doi: 10.1021/acs.jmedchem.5c03024. Online ahead of print.
2025
Induced proximity to PML protects TDP-43 from aggregation via SUMO–ubiquitin networks.
Wagner K, Keiten-Schmitz J, Adhikari B, Patra U, Husnjak K, McNicoll F, Dormann D, Müller-McNicoll M, Tascher G, Wolf E, Müller S.
Nat Chem Biol. 2025 Apr 17. doi: 10.1038/s41589-025-01886-4. Epub ahead of print.
Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription.
Bhandare P, Narain A, Hofstetter J, Rummel T, Wenzel J, Schülein-Völk C, Lamer S, Eilers U, Schlosser A, Eilers M, Erhard F, Wolf E.
Nucleic Acids Res. 2025 Feb 8;53(4):gkae1219.
Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.
Škapik IP, Giacomelli C, Hahn S, Deinlein H, Gallant P, Diebold M, Biayna J, Hendricks A, Olimski L, Otto C, Kastner C, Wolf E, Schülein-Völk C, Maurus K, Rosenwald A, Schleussner N, Jackstadt RF, Schlegel N, Germer CT, Bushell M, Eilers M, Schmidt S, Wiegering A.
EMBO J. 2025 Apr;44(7):2075-2105.
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.
Snaebjornsson MT, Poeller P, Komkova D, Röhrig F, Schlicker L, Winkelkotte AM, Chaves-Filho AB, Al-Shami KM, Caballero CD, Koltsaki I, Vogel FCE, Frias-Soler RC, Rudalska R, Schwarz JD, Wolf E, Dauch D, Steuer R, Schulze A.
Nat Metab. 2025 Feb;7(2):348-366.
Workflow for E3 Ligase Ligand Validation for PROTAC Development.
Miletić N, Weckesser J, Mosler T, Rathore R, Hoffmann ME, Gehrtz P, Schlesiger S, Hartung IV, Berner N, Wilhelm S, Müller J, Adhikari B, Němec V, Sivashanmugam SA, Elson L, Holzmann H, Schwalm MP, Hoffmann L, Abdul Azeez KR, Müller S, Kuster B, Wolf E, Đikić I, Knapp S.
ACS Chem Biol. 2025 Feb 21;20(2):507-521.
Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε.
Haag A, Němec V, Janovská P, Bartošíková J, Adhikari B, Müller J, Schwalm MP, Čada Š, Ohmayer U, Daub H, Kim Y, Born F, Wolf E, Bryja V, Knapp S.
J Med Chem. 2025 Jan 9;68(1):506-530.
2024
Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA)
Adhikari B, Schneider K, Diebold M, Sotriffer C, Wolf E.
Elife. 2024 Dec 6;13:RP98450.
Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches.
Seubert AC, Krafft M, Bopp S, Helal M, Bhandare P, Wolf E, Alemany A, Riedel A, Kretzschmar K.
Stem Cell Reports. 2 2024 Dec 10;19(12):1706-1719.
Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases.
Sflakidou E, Adhikari B, Siokatas C, Wolf E*, Sarli V*.
ACS Pharmacol Transl Sci. 2024 Oct 19;7(11):3488-3501. *corresponding authors
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer.
Reissland M, Hartmann O, Tauch S, Bugter JM, Prieto-Garcia C, Schulte C, Loebbert S, Solvie D, Bitman-Lotan E, Narain A, Jacomin AC, Schuelein-Voelk C, Fuss CT, Pahor N, Ade C, Buck V, Potente M, Li V, Beliu G, Wiegering A, Grossmann T, Eilers M, Wolf E, Maric H, Rosenfeldt M, Maurice MM, Dikic I, Gallant P, Orian A, Diefenbacher ME.
Oncogene. 2024 Dec;43(50):3645-3659.
Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2.
Vogt M, Dudvarski Stankovic N, Cruz Garcia Y, Hofstetter J, Schneider K, Kuybu F, Hauck T, Adhikari B, Hamann A, Rocca Y, Grysczyk L, Martin B, Gebhardt-Wolf A, Wiegering A, Diefenbacher M, Gasteiger G, Knapp S, Saur D, Eilers M, Rosenfeldt M, Erhard F, Vos SM, Wolf E.
Gut. 2024 Aug 8;73(9):1509-1528.
Correcting 4sU induced quantification bias in nucleotide conversion RNA-seq data.
Berg K, Lodha M, Delazer I, Bartosik K, Garcia YC, Hennig T, Wolf E, Dölken L, Lusser A, Prusty BK, Erhard F.
Nucleic Acids Res. 2024 Apr 24;52(7):e35.
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts.
Trifault B, Mamontova V, Cossa G, Ganskih S, Wei Y, Hofstetter J, Bhandare P, Baluapuri A, Nieto B, Solvie D, Ade CP, Gallant P, Wolf E, Larsen DH, Munschauer M, Burger K.
Nucleic Acids Res. 2024 Apr 12;52(6):3050-3068.
2023
Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila.
Hofstetter J, Ogunleye A, Kutschke A, Buchholz LM, Wolf E*, Raabe T*, Gallant P*.
Life Sci Alliance. 2023 Nov 7;7(1):e202302130. *corresponding authors
The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes.
Djakovic L, Henning T, Reinisch K, Milic A, Whisnant AW, Wolf K, Weiß E, Haas T, Grothey A, Jürgens CS, Kluge M, Wolf E, Erhard F, Friedel CC*, Dölken L*.
Nat Commun. 2023 Jul 31;14(1):4591. *corresponding authors
2022
MYC multimers shield stalled replication forks from RNA polymerase.
Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E*, Eilers M*.
Nature. 2022 Dec;612(7938):148-155. *corresponding authors
RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells.
Otto C, Kastner C, Schmidt S, Uttinger K, Baluapuri A, Denk S, Rosenfeldt MT, Rosenwald A, Roehrig F, Ade CP, Schuelein-Voelk C, Diefenbacher ME, Germer CT, Wolf E, Eilers M, Wiegering A.
Mol Oncol. 2022 Aug;16(15):2788-2809.
The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis.
Schwarz JD, Lukassen S, Bhandare P, Eing L, Snaebjörnsson MT, García YC, Kisker JP, Schulze A, Wolf E.
Front Cell Dev Biol. 2022 Sep 14;10:954358.
Novel, highly potent PROTACs targeting AURORA-A kinase.
Bozilovic J, Eing L, Berger BT, Adhikari B, Weckesser J, Berner NB, Wilhelm S, Kuster B, Wolf E*, Knapp S*.
Current Research in Chemical Biology 2:100032 *corresponding authors
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, den Dekker AT, Brouwer RWW, Baluapuri A, Habringer S, Reichert M, Illendula A, Krämer OH, Schick M, Wolf E, van IJcken WFJ, Esposito I, Keller U, Schneider G, Wirth M.
PNAS. 2022, 119(9).
Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma.
Riedel A, Helal M, Pedro L, Swietlik JJ, Shorthouse D, Schmitz W, Haas L, Young T, da Costa ASH, Davidson S, Bhandare P, Wolf E, Hall BA, Frezza C, Oskarsson T, Shields JD.
Cancer Immunol Res. 2022, 10(4):482-497.
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis andgenetic instability in diffuse large B-cell lymphoma
Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K,Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A,Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R,Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, OostendorpRAJ, Miething C, Lenhof HP, Bassermann F, Chapuy B, Wirth M, Wolf E, Rad R, Müller S, Keller U.
Nature Communications 13.
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.
Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M.
Mol Cell. 2022 Jan 6;82(1):159-176.e12.
MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress.
Sipol A, Hameister E, Xue B, Hofstetter J, Barenboim M, Öllinger R, Jain G, Prexler C, Rubio RA, Baldauf MC, Franchina DG, Petry A, Schmäh J, Thiel U, Görlach A, Cario G, Brenner D, Richter GHS, Grünewald TGP, Rad R, Wolf E, Ruland J, Sorensen PH, Burdach SEG.
Blood. 2022 Feb 24;139(8):1184-1197.
2021
Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination.
Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dölken L, Schlosser A, Erhard F*, Baluapuri A*, Wolf E*.
Molecular Cell, 2021 Aug 5;81(15):3110-3127.e14. *corresponding authors
Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease.
Hartmann O, Reissland M, Maier CR, Fischer T, Prieto-Garcia C, Baluapuri A, Schwarz J, Schmitz W, Garrido-Rodriguez M, Pahor N, Davies CC, Bassermann F, Orian A, Wolf E, Schulze A, Calzado MA, Rosenfeldt MT, Diefenbacher ME.
Front Cell Dev Biol. 2021 Mar 2;9:641618
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.
Dölle A, Adhikari B, Krämer A, Weckesser J, Berner N, Berger LM, Diebold M, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Gebel J, Löhr F, Dötsch V, Eilers M, Heinzlmeir S, Kuster B, Sotriffer C, Wolf E*, Knapp S.*
J Med Chem. 2021 Aug 12;64(15):10682-10710. *corresponding authors
Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells.
Adhikari B*, Narain A, Wolf E*.
STAR Protoc. 2021 Nov 19;2(4):100949. *corresponding authors
MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma.
Krenz B, Gebhardt-Wolf A, Ade CP, Gaballa A, Roehrig F, Vendelova E, Baluapuri A, Eilers U, Gallant P, D'Artista L, Wiegering A, Gasteiger G, Rosenfeldt MT, Bauer S, Zender L, Wolf E, Eilers M. Cancer Res. 2021 Aug 15;81(16):4242-4256.
Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP.
Cancer Res. 2021 Apr 1;81(7):1627-1632.
Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.
Endres T, Solvie D, Heidelberger JB, Andrioletti V, Baluapuri A, Ade CP, Muhar M, Eilers U, Vos SM, Cramer P, Zuber J, Beli P, Popov N, Wolf E, Gallant P, Eilers M.
Mol Cell. 2021 Feb 18;81(4):830-844.e13.
Plant roots employ cell-layer-specific programs to respond to pathogenic and beneficial microbes.
Fröschel C, Komorek J, Attard A, Marsell A, Lopez-Arboleda WA, Le Berre J, Wolf E, Geldner N, Waller F, Korte A, Dröge-Laser W.
Cell Host Microbe. 2021 Feb 10;29(2):299-310.e7.
2020
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.
Adhikari B, Bozilovic J, Diebold M, Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, Dudvarski Stankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, Schlosser A, Heinzlmeir S, Sotriffer C, Knapp S*, Wolf E*.
Nat Chem Biol. 2020 Nov;16(11):1179-1188. *corresponding authors
The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression.
Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W, Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M, Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E, Meierjohann S.
Oncogene. 2020 Oct;39(44):6841-6855.
Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis.
Rajeeve K, Vollmuth N, Janaki-Raman S, Wulff TF, Baluapuri A, Dejure FR, Huber C, Fink J, Schmalhofer M, Schmitz W, Sivadasan R, Eilers M, Wolf E, Eisenreich W, Schulze A, Seibel J, Rudel T.
Nat Microbiol. 2020 Nov;5(11):1390-1402.
Targeting MYC Proteins for Tumor Therapy
Wolf E* and Eilers M*.
Annual Review of Cancer Biology, 2020, 4 *corresponding authors
Target gene-independent functions of MYC oncoproteins.
Baluapuri A, Wolf E, Eilers M.
Nat Rev Mol Cell Biol. 2020 May;21(5):255-267.
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa G, Roeschert I, Prinz F, Baluapuri A, Vidal RS, Schülein-Völk C, Chang YC, Ade CP, Mastrobuoni G, Girard C, Kumar A, Wortmann L, Walz S, Lührmann R, Kempa S, Kuster B, Wolf E, Mumberg D, Eilers M.
Mol Cell. 2021 Jun 3;81(11):2495. Erratum for: Mol Cell. 2020 Mar 19;77(6):1322-1339.e11.
2019
MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation.
Baluapuri A*, Hofstetter J*, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E.
Mol Cell 2019 May 16;74(4):674-687.e11. *joint first authors
A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A.
Nat Cell Biol. 2019 Nov;21(11):1413-1424.
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase.
Herold S, Kalb J, Büchel G, Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C, Dobbelstein M, Wolf E, Molenaar J, Versteeg R, Walz S, Eilers M.
Nature. 2019 Mar;567(7749):545-549.
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
Dammert MA, Brägelmann J, Olsen RR, Böhm S, Monhasery N, Whitney CP, Chalishazar MD, Tumbrink HL, Guthrie MR, Klein S, Ireland AS, Ryan J, Schmitt A, Marx A, Ozretić L, Castiglione R, Lorenz C, Jachimowicz RD, Wolf E, Thomas RK, Poirier JT, Büttner R, Sen T, Byers LA, Reinhardt HC, Letai A, Oliver TG, Sos ML.
Nat Commun. 2019 Aug 2;10(1):3485.
MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.
Annunziata I, van de Vlekkert D, Wolf E, Finkelstein D, Neale G, Machado E, Mosca R, Campos Y, Tillman H, Roussel MF, Andrew Weesner J, Ellen Fremuth L, Qiu X, Han MJ, Grosveld GC, d'Azzo A.
Nat Commun. 2019 Aug 9;10(1):3623.
The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes.
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, von Eyss B, Gaubatz S.
Cell Rep. 2019 Jun 18;27(12):3533-3546.e7.
Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells.
Otto C, Schmidt S, Kastner C, Denk S, Kettler J, Müller N, Germer CT, Wolf E, Gallant P, Wiegering A.
Neoplasia. 2019 Nov;21(11):1110-1120.
2018
Snf1-RELATED KINASE1-Controlled C/S1-bZIP Signaling Activates Alternative Mitochondrial Metabolic Pathways to Ensure Plant Survival in Extended Darkness.
Pedrotti L, Weiste C, Nägele T, Wolf E, Lorenzin F, Dietrich K, Mair A, Weckwerth W, Teige M, Baena-González E, Dröge-Laser W.
Plant Cell. 2018 Feb;30(2):495-509.
2017
Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.
Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M.
Cell Rep. 2017 Dec 19;21(12):3483-3497.
PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters.
Gerlach JM, Furrer M, Gallant M, Birkel D, Baluapuri A, Wolf E, Gallant P.
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9224-E9232.
The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.
Dejure FR, Royla N, Herold S, Kalb J, Walz S, Ade CP, Mastrobuoni G, Vanselow JT, Schlosser A, Wolf E, Kempa S, Eilers M.
EMBO J. 2017 Jul 3;36(13):1854-1868.
Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S.
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8029-8034.
OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M.
Oncogene. 2017 Apr 6;36(14):1911-1924.
2016
Different promoter affinities account for specificity in MYC-dependent gene regulation.
Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E.
Elife. 2016 Jul 27;5:e15161.
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
Vo BT*, Wolf E*, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M, Roussel MF.
Cancer Cell. 2016 Jan 11;29(1):5-16. *joint first authors
The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells.
King B, Boccalatte F, Moran-Crusio K, Wolf E, Wang J, Kayembe C, Lazaris C, Yu X, Aranda-Orgilles B, Lasorella A, Aifantis I.
Nat Immunol. 2016 Nov;17(11):1312-1321.
Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.
Jaenicke LA, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg AK, Geyer M, Eilers M, Popov N.
Mol Cell. 2016 Jan 7;61(1):54-67.
2015
LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation.
Küspert M, Murakawa Y, Schäffler K, Vanselow JT, Wolf E, Juranek S, Schlosser A, Landthaler M, Fischer U.
RNA. 2015 Jul;21(7):1294-305.
snoRNAs are a novel class of biologically relevant Myc targets.
Herter EK, Stauch M, Gallant M, Wolf E, Raabe T, Gallant P.
BMC Biol. 2015 Apr 16;13:25.
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.
Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M.
EMBO J. 2015 Jun 3;34(11):1554-71.
Taming of the beast: shaping Myc-dependent amplification.
Wolf E, Lin CY, Eilers M, Levens DL.
Trends Cell Biol. 2015 Apr;25(4):241-8.
Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.
Weber D, Heisig J, Kneitz S, Wolf E, Eilers M, Gessler M.
J Mol Cell Cardiol. 2015 Feb;79:79-88.
Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.
Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R.
EMBO Rep. 2015 Dec;16(12):1723-36.
2014
Dual regulation of Fbw7 function and oncogenic transformation by Usp28.
Schülein-Völk C, Wolf E, Zhu J, Xu W, Taranets L, Hellmann A, Jänicke LA, Diefenbacher ME, Behrens A, Eilers M, Popov N.
Cell Rep. 2014 Nov 6;9(3):1099-109.
BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues.
Muthalagu N, Junttila MR, Wiese KE, Wolf E, Morton J, Bauer B, Evan GI, Eilers M, Murphy DJ.
Cell Rep. 2014 Sep 11;8(5):1347-53.
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.
Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E*, Eilers M*.
Nature. 2014 Jul 24;511(7510):483-7. *corresponding authors
Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.
Baumgart S, Chen NM, Siveke JT, König A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Urrutia R, Ellenrieder V.
Cancer Discov. 2014 Jun;4(6):688-701.
Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.
Sanz-Moreno A, Fuhrmann D, Wolf E, von Eyss B, Eilers M, Elsässer HP.
PLoS One. 2014 Feb 19;9(2):e89187.
2013
The role of MIZ-1 in MYC-dependent tumorigenesis.
Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M.
Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a014290.
Miz1 is required to maintain autophagic flux.
Wolf E*, Gebhardt A*, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M.
Nat Commun. 2013;4:2535. *these authors contributed equally
2012
Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex.
Wolf E, Kastner B, Lührmann R.
RNA. 2012 Jul;18(7):1347-57.
Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.
Hönnemann J, Sanz-Moreno A, Wolf E, Eilers M, Elsässer HP.
PLoS One. 2012;7(4):e34885.
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.
Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M.
PLoS Genet. 2012;8(5):e1002728.
2011
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method.
Agafonov DE, Deckert J, Wolf E, Odenwälder P, Bessonov S, Will CL, Urlaub H, Lührmann R.
Mol Cell Biol. 2011 Jul;31(13):2667-82.
2010
3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core.
Golas MM, Sander B, Bessonov S, Grote M, Wolf E, Kastner B, Stark H, Lührmann R.
Mol Cell. 2010 Dec 22;40(6):927-38.
Molecular architecture of the human Prp19/CDC5L complex.
Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A, Fischle W, Urlaub H, Lührmann R.
Mol Cell Biol. 2010 May;30(9):2105-19.
2009
Exon, intron and splice site locations in the spliceosomal B complex.
Wolf E, Kastner B, Deckert J, Merz C, Stark H, Lührmann R.
EMBO J. 2009 Aug 5;28(15):2283-92.
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes.
Herold N, Will CL, Wolf E, Kastner B, Urlaub H, Lührmann R.
Mol Cell Biol. 2009 Jan;29(1):281-301.
2008
Exon, intron and splice site locations in the spliceosomal B complex.
Wolf E, Kastner B, Deckert J, Merz C, Stark H, Lührmann R.
EMBO J. 2009 Aug 5;28(15):2283-92.
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes.
Herold N, Will CL, Wolf E, Kastner B, Urlaub H, Lührmann R.
Mol Cell Biol. 2009 Jan;29(1):281-301.
2006
Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques.
Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T.
J Mol Biol. 2006 Feb 3;355(5):1048-65.