Publications
2022
Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc).
Schulte DM, Waetzig GH, Schuett H, Marx M, Schulte B, Garbers C, Lokau J, Vlacil AK, Schulz J, Seoudy AK, Schieffer B, Rosenstiel P, Seeger M, Laudes M, Rose-John S, Lützen U, Grote K, Schreiber S.
Front Pharmacol. 2022 Jun 9;13:758233.
The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo. Kirschke S, Ogunsulire I, Selvakumar B, Schumacher N, Sezin T, Rose-John S, Scheffold A, Garbers C, Lokau J.
J Biol Chem. 2022 Jun;298(6):101910.
Identification of IL-6 Signalling Components as Predictors of Severity and Outcome in COVID-19.
Rodríguez-Hernández MÁ, Carneros D, Núñez-Núñez M, Coca R, Baena R, López-Ruiz GM, Cano-Serrano ME, Martínez-Tellería A, Fuentes-López A, Praena-Fernandez JM, Garbers C, Hernández-Quero J, García F, Rose-John S, Bustos M.
Front Immunol. 2022 May 13;13:891456.
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Prieto Huarcaya S, Drobny A, Marques ARA, Di Spiezio A, Dobert JP, Balta D, Werner C, Rizo T, Gallwitz L, Bub S, Stojkovska I, Belur NR, Fogh J, Mazzulli JR, Xiang W, Fulzele A, Dejung M, Sauer M, Winner B, Rose-John S, Arnold P, Saftig P, Zunke F.
Autophagy. 2022 May;18(5):1127-1151.
IL-6 Responsiveness of CD4+ and CD8+ T Cells after Allogeneic Stem Cell Transplantation Differs between Patients and Is Associated with Previous Acute Graft versus Host Disease and Pretransplant Antithymocyte Globulin Therapy.
Tvedt THA, Rose-John S, Tsykunova G, Ahmed AB, Gedde-Dahl T, Ersvær E, Bruserud Ø.
J Clin Med. 2022 Apr 30;11(9):2530.
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.
Mentrup T, Stumpff-Niggemann AY, Leinung N, Schlosser C, Schubert K, Wehner R, Tunger A, Schatz V, Neubert P, Gradtke AC, Wolf J, Rose-John S, Saftig P, Dalpke A, Jantsch J, Schmitz M, Fluhrer R, Jacobsen ID, Schröder B.
Nat Commun. 2022 Apr 6;13(1):1880.
Mechanisms of interorgan crosstalk in health and disease.
Herrlich A, Kefaloyianni E, Rose-John S.
FEBS Lett. 2022 Mar;596(5):529-533.
Enhancement of proliferation of human umbilical cord blood-derived CD34+ hematopoietic stem cells by a combination of hyper-interleukin-6 and small molecules.
Park YS, Lee Y, Choi NY, Hwang HS, Rose-John S, Zenke M, Ko K.
Biochem Biophys Rep. 2022 Jan 27;29:101214.
Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia.
Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, V Koningsbruggen-Rietschel S, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dötsch J, Alejandre Alcazar MA.
Eur Respir J. 2022 Feb 17;59(2):2002248.
IL-6- induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
Dudek M, Lohr K, Donakonda S, Baumann T, Lüdemann M, Hegenbarth S, Dübbel L, Eberhagen C, Michailidou S, Yassin A, Prinz M, Popper B, Rose-John S, Zischka H, Knolle PA.
Cell Rep. 2022 Feb 15;38(7):110389.
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D.
J Exp Med. 2022 Jan 3;219(1):e20201039.
ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer.
Schumacher N, Rose-John S.
Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119141.
By Year
2021
Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells.
Fritsch J, Frankenheim J, Marischen L, Vadasz T, Troeger A, Rose-John S, Schmidt-Arras D, Schneider-Brachert W.
Cells. 2021 Nov 10;10(11):3100. 2021 Nov;18(11):787-803.
Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring.
Breuer S, Kasper P, Vohlen C, Janoschek R, Hoffmann T, Appel S, Müller-Limberger E, Mesaros A, Rose-John S, Garbers C, Müller S, Lackmann JW, Mahabir E, Dötsch J, Hucklenbruch-Rother E, Bae-Gartz I.
Nutrients. 2021 Oct 23;13(11):3735.
Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.
Künzel SR, Hoffmann M, Weber S, Künzel K, Kämmerer S, Günscht M, Klapproth E, Rausch JSE, Sadek MS, Kolanowski T, Meyer-Roxlau S, Piorkowski C, Tugtekin SM, Rose-John S, Yin X, Mayr M, Kuhlmann JD, Wimberger P, Grützmann K, Herzog N, Küpper JH, O'Reilly M, Kabir SN, Sommerfeld LC, Guan K, Wielockx B, Fabritz L, Nattel S, Ravens U, Dobrev D, Wagner M, El-Armouche A.
Circ Res. 2021 Oct;129(8):804-820.
Identification of the factor XII contact activation site enables sensitive coagulation diagnostics.
Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jämsä A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer JR, Rose-John S, Butler LM, Salomon O, Stavrou EX, Renné T.
Nat Commun. 2021 Sep 22;12(1):5596.
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis.
Del Poggetto E, Ho IL, Balestrieri C, Yen EY, Zhang S, Citron F, Shah R, Corti D, Diaferia GR, Li CY, Loponte S, Carbone F, Hayakawa Y, Valenti G, Jiang S, Sapio L, Jiang H, Dey P, Gao S, Deem AK, Rose-John S, Yao W, Ying H, Rhim AD, Genovese G, Heffernan TP, Maitra A, Wang TC, Wang L, Draetta GF, Carugo A, Natoli G, Viale A.
Science. 2021 Sep 17;373(6561):eabj0486.
Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis.
Shriki A, Lanton T, Sonnenblick A, Levkovitch-Siany O, Eidelshtein D, Abramovitch R, Rosenberg N, Pappo O, Elgavish S, Nevo Y, Safadi R, Peled A, Rose-John S, Galun E, Axelrod JH.
Cancer Res. 2021 Sep 15;81(18):4766-4777.
Macrophage-derived IL-6 trans-signaling as a novel target in the pathogenesis of bronchopulmonary dysplasia.
Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, Koningsbruggen-Rietschel SV, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dötsch J, Alejandre Alcazar MA.
Eur Respir J. 2021 Aug 26:2002248.
The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis.
Davies R, Williams J, Sime K, Jin HS, Thompson C, Jordan L, Lang D, Halcox JP, Ellins E, Jones GW, Jones SA, Rose-John S, Williams A, Choy E.
Rheumatology (Oxford). 2021 Jun 18;60(6):2852-2861.
Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance.
Reif A, Lam K, Weidler S, Lott M, Boos I, Lokau J, Bretscher C, Mönnich M, Perkams L, Schmälzlein M, Graf C, Fischer JP, Lechner C, Hallstein K, Becker S, Weyand M, Steegborn C, Schultheiss G, Rose-John S, Garbers C, Unverzagt C.
Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13380-13387.
Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease.
Schreiber S, Aden K, Bernardes JP, Conrad C, Tran F, Höper H, Volk V, Mishra N, Blase JI, Nikolaus S, Bethge J, Kühbacher T, Röcken C, Chen M, Cottingham I, Petri N, Rasmussen BB, Lokau J, Lenk L, Garbers C, Feuerhake F, Rose-John S, Waetzig GH, Rosenstiel P.
Gastroenterology. 2021 Jun;160(7):2354-2366.e11.
Initiation of Pancreatic Cancer: The Interplay of Hyperglycemia and Macrophages Promotes the Acquisition of Malignancy-Associated Properties in Pancreatic Ductal Epithelial Cells.
Otto L, Rahn S, Daunke T, Walter F, Winter E, Möller JL, Rose-John S, Wesch D, Schäfer H, Sebens S.
Int J Mol Sci. 2021 May 11;22(10):5086.
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate.
Mailer RK, Allende M, Heestermans M, Schweizer M, Deppermann C, Frye M, Pula G, Odeberg J, Gelderblom M, Rose-John S, Sickmann A, Blankenberg S, Huber TB, Kubisch C, Maas C, Gambaryan S, Firsov D, Stavrou EX, Butler LM, Renné T.
Blood. 2021 Mar 11;137(10):1392-1405.
Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice.
Westermann LM, Baranowsky A, Di Lorenzo G, Danyukova T, Soul J, Schwartz JM, Hendrickx G, Amling M, Rose-John S, Garbers C, Schinke T, Pohl S.
Sci Rep. 2021 Feb 11;11(1):3556.
Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19.
Garbers C, Rose-John S.
Lancet Rheumatol. 2021 Feb;3(2):e96-e97.
ADAM17 Deficiency Protects against Pulmonary Emphysema.
Saad MI, McLeod L, Hodges C, Vlahos R, Rose-John S, Ruwanpura S, Jenkins BJ.
Am J Respir Cell Mol Biol. 2021 Feb;64(2):183-195.
Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice.
Schumacher N, Yan K, Gandraß M, Müller M, Krisp C, Häsler R, Carambia A, Nofer JR, Bernardes JP, Khouja M, Thomsen I, Chalupsky K, Bolik J, Hölscher C, Wunderlich T, Herkel J, Rosenstiel P, Schramm C, Schlüter H, Renné T, Mittrücker HW, Rose-John S, Schmidt-Arras D.
J Hepatol. 2021 Feb;74(2):407-418.
NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy.
Koerdel K, Spitzner M, Meyer T, Engels N, Krause F, Gaedcke J, Conradi LC, Haubrock M, Beißbarth T, Leha A, Johnsen SA, Ghadimi BM, Rose-John S, Grade M, Wienands J.
Cancers (Basel). 2021 Jan 26;13(3):455.
Interleukin-6 controls recycling and degradation, but not internalization of its receptors.
Flynn CM, Kespohl B, Daunke T, Garbers Y, Düsterhöft S, Rose-John S, Haybaeck J, Lokau J, Aparicio-Siegmund S, Garbers C.
J Biol Chem. 2021 Jan-Jun;296:100434.
2020
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro.
Flynn CM, Garbers Y, Düsterhöft S, Wichert R, Lokau J, Lehmann CHK, Dudziak D, Schröder B, Becker-Pauly C, Rose-John S, Aparicio-Siegmund S, Garbers C.
Sci Rep. 2020 Dec 10;10(1):21612.
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.
Gleitz HFE, Dugourd AJF, Leimkühler NB, Snoeren IAM, Fuchs SNR, Menzel S, Ziegler S, Kröger N, Triviai I, Büsche G, Kreipe H, Banjanin B, Pritchard JE, Hoogenboezem R, Bindels EM, Schumacher N, Rose-John S, Elf S, Saez-Rodriguez J, Kramann R, Schneider RK.
Blood. 2020 Oct 29;136(18):2051-2064.
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Werner-Klein M, Grujovic A, Irlbeck C, Obradović M, Hoffmann M, Koerkel-Qu H, Lu X, Treitschke S, Köstler C, Botteron C, Weidele K, Werno C, Polzer B, Kirsch S, Gužvić M, Warfsmann J, Honarnejad K, Czyz Z, Feliciello G, Blochberger I, Grunewald S, Schneider E, Haunschild G, Patwary N, Guetter S, Huber S, Rack B, Harbeck N, Buchholz S, Rümmele P, Heine N, Rose-John S, Klein CA.
Nat Commun. 2020 Oct 5;11(1):4977.
IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants.
Bartsch YC, Eschweiler S, Leliavski A, Lunding HB, Wagt S, Petry J, Lilienthal GM, Rahmöller J, de Haan N, Hölscher A, Erapaneedi R, Giannou AD, Aly L, Sato R, de Neef LA, Winkler A, Braumann D, Hobusch J, Kuhnigk K, Krémer V, Steinhaus M, Blanchard V, Gemoll T, Habermann JK, Collin M, Salinas G, Manz RA, Fukuyama H, Korn T, Waisman A, Yogev N, Huber S, Rabe B, Rose-John S, Busch H, Berberich-Siebelt F, Hölscher C, Wuhrer M, Ehlers M.
J Allergy Clin Immunol. 2020 Sep;146(3):652-666.e11.
Letter to the Editor: Non-specific effects resulting from use of tocilizumab in mice.
Lokau J, Waetzig GH, Rose-John S, Garbers C.
Metabolism. 2020 Aug;109:154281.
ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation.
Schumacher N, Rose-John S, Schmidt-Arras D.
Int J Mol Sci. 2020 Jul 20;21(14):5133.
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C.
Gut. 2020 Jul;69(7):1269-1282.
The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis.
Saad MI, McLeod L, Yu L, Ebi H, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.
Carcinogenesis. 2020 Jun 17;41(4):527-538.
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.
Schwerd T, Krause F, Twigg SRF, Aschenbrenner D, Chen YH, Borgmeyer U, Müller M, Manrique S, Schumacher N, Wall SA, Jung J, Damm T, Glüer CC, Scheller J, Rose-John S, Jones EY, Laurence A, Wilkie AOM, Schmidt-Arras D, Uhlig HH.
Bone Res. 2020 Jun 11;8:24.
Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles.
Arnold P, Lückstädt W, Li W, Boll I, Lokau J, Garbers C, Lucius R, Rose-John S, Becker-Pauly C.
Cells. 2020 May 24;9(5):1307
Soluble interleukin-6 receptor in patients with JAK2V617F somatic mutation and myeloproliferative neoplasm.
Garbers C, Rose-John S.
EClinicalMedicine. 2020 May 3;22:100340
Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells.
Lokau J, Kleinegger F, Garbers Y, Waetzig GH, Grötzinger J, Rose-John S, Haybaeck J, Garbers C.
PLoS One. 2020 May 4;15(5):e0232612
Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner.
Willis EF, MacDonald KPA, Nguyen QH, Garrido AL, Gillespie ER, Harley SBR, Bartlett PF, Schroder WA, Yates AG, Anthony DC, Rose-John S, Ruitenberg MJ, Vukovic J.
Cell. 2020 Mar 5;180(5):833-846
Interleukin-6 plays a critical role in aldosterone-induced macrophage recruitment and infiltration in the myocardium.
Liao CW, Chou CH, Wu XM, Chen ZW, Chen YH, Chang YY, Wu VC, Rose-John S, Hung CS, Lin YH; TAIPAI Study Group.
Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165627
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C.
Cell Mol Life Sci. 2020 Jan;77(2):331-350
2019
IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling.
Wilkinson AN, Chang K, Kuns RD, Henden AS, Minnie SA, Ensbey KS, Clouston AD, Zhang P, Koyama M, Hidalgo J, Rose-John S, Varelias A, Vuckovic S, Gartlan KH, Hill GR.
Blood. 2019 Dec 5;134(23):2092-2106
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C.
Gut. Jul;69(7):1269-1282
IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease.
Escrig A, Canal C, Sanchis P, Fernández-Gayol O, Montilla A, Comes G, Molinero A, Giralt M, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J.
Brain Behav Immun. 2019 Nov;82:145-159
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C.
FASEB J. 2019 Nov;33(11):11925-11940
Treatment of type 2 diabetes with the designer cytokine IC7Fc.
Findeisen M, Allen TL, Henstridge DC, Kammoun H, Brandon AE, Baggio LL, Watt KI, Pal M, Cron L, Estevez E, Yang C, Kowalski GM, O'Reilly L, Egan C, Sun E, Thai LM, Krippner G, Adams TE, Lee RS, Grötzinger J, Garbers C, Risis S, Kraakman MJ, Mellet NA, Sligar J, Kimber ET, Young RL, Cowley MA, Bruce CR, Meikle PJ, Baldock PA, Gregorevic P, Biden TJ, Cooney GJ, Keating DJ, Drucker DJ, Rose-John S, Febbraio MA.
Nature. 2019 Oct;574(7776):63-68
Interleukin 6 Dependent Synaptic Plasticity in a Social Defeat-Susceptible Prefrontal Cortex Circuit.
Esquivel-Rendón E, Vargas-Mireles J, Cuevas-Olguín R, Miranda-Morales M, Acosta-Mares P, García-Oscos F, Pineda JC, Salgado H, Rose-John S, Atzori M.
Neuroscience 2019 Aug 21;414:280-296
Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma.
Scherger AK, Al-Maarri M, Maurer HC, Schick M, Maurer S, Öllinger R, Gonzalez-Menendez I, Martella M, Thaler M, Pechloff K, Steiger K, Sander S, Ruland J, Rad R, Quintanilla-Martinez L, Wunderlich FT, Rose-John S, Keller U.
JCI Insight 2019 Aug 8;4(15)
The IL-6-neutralizing sIL-6R/sgp130 buffer system is disturbed in patients with type 2 diabetes.
Aparicio-Siegmund S, Garbers Y, Flynn CM, Waetzig GH, Gouni-Berthold I, Krone W, Berthold HK, Laudes M, Rose-John S, Garbers C.
Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E411-E420
The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients.
Dos Santos Guilherme M, Stoye NM, Rose-John S, Garbers C, Fellgiebel A, Endres K.
Front Aging Neurosci. 2019 Jul 23;11:182
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.
Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C.
Int J Mol Sci. 2019 Jul 26;20(15)
Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3.
Servais FA, Kirchmeyer M, Hamdorf M, Minoungou NWE, Rose-John S, Kreis S, Haan C, Behrmann I.
Mol Ther Nucleic Acids. 2019 Jun 7;16:419-433
Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation.
Pavlenko E, Cabron AS, Arnold P, Dobert JP, Rose-John S, Zunke F.
Int J Mol Sci. 2019 May 4;20(9)
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.
EMBO Mol Med. 2019 Apr;11(4)
ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury.
Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, Bogie J, Vanmierlo T, Vidal PM, Rose-John S, Gou-Fabregas M, Hendrix S.
Brain Behav Immun. 2019 Mar 6
Impaired mechanical, heat, and cold nociception in a murine model of genetic TACE/ADAM17 knockdown.
Quarta S, Mitrić M, Kalpachidou T, Mair N, Schiefermeier-Mach N, Andratsch M, Qi Y, Langeslag M, Malsch P, Rose-John S, Kress M.
FASEB J. 2019 Mar;33(3):4418-4431
Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.
Kleinegger F, Hofer E, Wodlej C, Golob-Schwarzl N, Birkl-Toeglhofer AM, Stallinger A, Petzold J,Orlova A, Krassnig S, Reihs R, Niedrist T, Mangge H, Park YN, Thalhammer M, Aigelsreiter A, Lax S, Garbers C, Fickert P, Rose-John S, Moriggl R, Rinner B, Haybaeck J.
Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):308-321
Correction to: A new multiple trauma model of the mouse.
Fitschen-Oestern S, Lippross S, Klueter T, Weuster M, Varoga D, Tohidnezhad M, Pufe T, Rose-John S, Andruszkow H, Hildebrand F, Steubesand N, Seekamp A, Neunaber C.
BMC Musculoskelet Disord. 2019 Feb 11;20(1):72
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Paige E, Clément M, Lareyre F, Sweeting M, Raffort J, Grenier C, Finigan A, Harrison J, Peters JE, Sun BB, Butterworth AS, Harrison SC, Bown MJ, Lindholt JS, Badger SA, Kullo IJ, Powell J, Norman PE, Scott DJA, Bailey MA, Rose-John S, Danesh J, Freitag DF, Paul DS, Mallat Z.
Circ Genom Precis Med. 2019 Feb;12(2):e002413
Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation byproteolytic cleavage.
Prenissl N, Lokau J, Rose-John S, Haybaeck J, Garbers C.
Cytokine. 2019 Feb;114:1-5
Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.
Agthe M, Brügge J, Garbers Y, Wandel M, Kespohl B, Arnold P, Flynn CM, Lokau J, Aparicio-Siegmund S, Bretscher C, Rose-John S, Waetzig GH, Putoczki T, Grötzinger J, Garbers C.
Cell rep.2019 Jan;156(1):145-159.e19
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice.
Aden K, Bartsch K, Dahl J, Reijns MAM, Esser D, Sheibani-Tezerji R, Sinha A, Wottawa F, Ito G, Mishra N, Knittler K, Burkholder A, Welz L, van Es J, Tran F, Lipinski S, Kakavand N, Boeger C, Lucius R, von Schoenfels W, Schafmayer C, Lenk L, Chalaris A, Clevers H, Röcken C, Kaleta C, Rose-John S, Schreiber S, Kunkel T, Rabe B, Rosenstiel P.
Gastroenterology.2019 Jan;156(1):145-159.e19
Interleukin 6 Trans-Signalling and Risk of Future Cardiovascular Events.
Ziegler L, Gajulapuri A, Frumento P, Bonomi A, Wallén H, de Faire U, Rose-John S, Gigante B.
Cardiovasc Res 2019 Jan 1;115(1):213-221
2018
Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe C, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A, Seufferlein T.
J Clin Invest 2018 Nov 1;128(11):5056-5072
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.
Cabron AS, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, Dobert JP, Pavlenko E, Schumacher N,Renné T, Taylor PR, Linder S, Rose-John S, Zunke F.
J Immunol 2018 Nov 15;201(10):3106-3118
Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis.
Stahl FR, Jung R, Jazbutyte V, Ostermann E, Tödter S, Brixel R, Kemmer A, Halle S, Rose-John S, Messerle M, Arck PC, Brune W, Renné T.
Sci Rep 2018 Oct 4;8(1):14823
Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Nivarthi H, Gordziel C,Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S,Friedrich K, Moriggl R.
Oncotarget 2018 Sep 18;9(73):33865
Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells.
Lücke K, Yan I, Krohn S, Volmari A, Klinge S, Schmid J, Schumacher V, Steinmetz OM, Rose-John S, Mittrücker HW.
PLoS One 2018 Aug 31;13(8):e0203395
Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice.
Holz K, Prinz M, Brendecke SM, Hölscher A, Deng F, Mitrücker HW, Rose-John S, Hölscher C.
Front Immunol 2018 May 2;9:836
Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma.
Kaiser K, Prystaz K, Vikman A, Haffner-Luntzer M, Bergdolt S, Strauss G, Waetzig GH, Rose-John S, Ignatius A.
Naunyn Schmiedebergs Arch Pharmacol 2018 May;391(5):523-536
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.
J Exp Med 2018 Apr 2;215(4):1205-1225
BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.
Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K.
J Clin Invest 2018 Mar 1;128(3):916-930
Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer.
Garbers C, Rose-John S.
Methods Mol Biol. 2018;1725:127-140
The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpectedfunction of ADAM-17 in necroptosis.
Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D.
Oncotarget 2018 Feb 5;9(16):12941-12958
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.
Prystaz K, Kaiser K, Kovtun A, Haffner-Luntzer M, Fischer V, Rapp AE, Liedert A, Strauss G, Waetzig GH, Rose-John S, Ignatius A.
Am J Pathol. 2018 Feb;188(2):474-490
The ADAM17 Metalloproteinase Maintains Arterial Elasticity.
Nicolaou A, Northoff BH, Zhao Z, Kohlmaier A, Sass K, Rose-John S, Steffens S, Weber C, Teupser D, Holdt LM.
Thromb Haemost 2018 Jan;118(1):210-213
Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.
Dixit A, Bottek J, Beerlage AL, Schuettpelz J, Thiebes S, Brenzel A, Garbers C, Rose-John S, Mittrücker HW, Squire A, Engel DR.
J Leukoc Biol. 2018 Jan;103(1):13-22
2017
Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Hölscher C.
Front Immunol. 2017 Nov 10;8:1537
The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.
Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.
Oncoimmunology 2017 Oct 26;7(1):e1368603
Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.
Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.
Front Physiol. 2017 Oct 9;8:775
The role of ADAM17 in the T-cell response against bacterial pathogens.
Link MA, Lücke K, Schmid J, Schumacher V, Eden T, Rose-John S, Mittrücker HW.
PLoS One. 2017 Sep 6;12(9):e0184320
Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice.
Tode J, Richert E, Koinzer S, Klettner A, Pickhinke U, Garbers C, Rose-John S, Nölle B, Roider J.
Cytokine. 2017 Aug;96:8-15
Cancer- associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C.
Oncotarget 2017 Jul 4;8(33):54873-54888
EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.
Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M.
Gastroenterology 2017 Jul;153(1):178-190.e10
Over- expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.
Kammoun HL, Allen TL, Henstridge DC, Kraakman MJ, Peijs L, Rose-John S, Febbraio MA.
PLoS One. 2017 Jun 20;12(6):e0179099
IL6- Dependent Genomic Instability Heralds Accelerated Carcinogenesis Following Liver Regeneration on a Background of Chronic Hepatitis.
Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, Rosenberg N, Paldor M, Goldenberg D, Sonnenblick A, Peled A, Rose-John S, Galun E, Axelrod JH.
Hepatology. 2017 May;65(5):1600-1611
Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.
Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose-John S, Knolle PA, Wohlleber D.
J Hepatol. 2017 May;66(5):978-986
IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.
Timper K, Denson JL, Steculorum SM, Heilinger C, Engström-Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT, Brüning JC.
Cell Rep. 2017 Apr 11;19(2):267-280
The balance between Treg and TH17 cells: CD11b and interleukin-6.
Garbers C, Rose-John S.
Eur J Immunol. 2017 Apr;47(4):629-632
Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
Balic JJ, Garbers C, Rose-John S, Yu L, Jenkins BJ.
Cytokine. 2017 Apr;92:118-123
Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.
Sontag S, Förster M, Qin J, Wanek P, Mitzka S, Schüler HM, Koschmieder S, Rose-John S, Seré K, Zenke M.
Stem Cells. 2017 Apr;35(4):898-908
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.
Sci Rep. 2017 Mar 9;7:44053
Instructive Role of the Microenvironment in Preventing Renal Fibrosis.
Matsumoto K, Xavier S, Chen J, Kida Y, Lipphardt M, Ikeda R, Gevertz A, Caviris M, Hatzopoulos AK, Kalajzic I, Dutton J, Ratliff BB, Zhao H, Darzynkiewicz Z, Rose-John S, Goligorsky MS.
Stem Cells Transl Med. 2017 Mar;6(3):992-1005
Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth.
Burger R, Günther A, Klausz K, Staudinger M, Peipp M, Penas EM, Rose-John S, Wijdenes J, Gramatzki M.
Haematologica. 2017 Feb;102(2):381-390
Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM.
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):247-257
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.
Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.
PLoS Biol. 2017 Jan 6;15(1):e2000080
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.
Nat Immunol. 2017 Jan;18(1):74-85
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.
Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D.
Hepatology. 2017 Jan;65(1):89-103
2016
Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.
Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ.
Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.
Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P.
Oncogenesis. 2016 Nov 21;5(11):e270
Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.
Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.
J Immunol. 2016 Nov 1;197(9):3705-3715
Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts.
Heckt T, Keller J, Peters S, Streichert T, Chalaris A, Rose-John S, Mell B, Joe B, Amling M, Schinke T.
Bone. 2016 Nov;92:85-93
Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.
Kalinin DV, Wagner S, Riemann B, Hermann S, Schmidt F, Becker-Pauly C, Rose-John S, Schäfers M, Holl R.
J Med Chem. 2016 Oct 27;59(20):9541-9559
ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A.
JCI Insight. 2016 Aug 18;1(13)
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response.
Heim D, Gil-Ibanez I, Herden J, Parplys AC, Borgmann K, Schmidt-Arras D, Lohse AW, Rose-John S, Wege H.
Oncotarget. 2016 Aug 23;7(34):55639-55648
Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A.
Elife. 2016 Aug 1;5
Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling.
Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, Garbers C.
J Biol Chem. 2016 Jul 29;291(31):16186-96
Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.
Wörmann SM, Song L, Ai J, Diakopoulos KN, Kurkowski MU, Görgülü K, Ruess D, Campbell A, Doglioni C, Jodrell D, Neesse A, Demir IE, Karpathaki AP, Barenboim M, Hagemann T, Rose-John S, Sansom O, Schmid RM, Protti MP, Lesina M, Algül H.
Gastroenterology. 2016 Jul;151(1):180-193.e12
Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer.
Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K
Gut. 2016 Jul;65(7):1139-50
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.
Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, Barrett DM, Weiss SL, Fitzgerald JC, Berg RA, Aplenc R, Callahan C, Rheingold SR, Zheng Z, Rose-John S, White JC, Nazimuddin F, Wertheim G, Levine BL, June CH, Porter DL, Grupp SA.
Cancer Discov. 2016 Jun;6(6):664-79
Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.
Riethmueller S, Ehlers JC, Lokau J, Düsterhöft S, Knittler K, Dombrowsky G, Grötzinger J, Rabe B, Rose-John S, Garbers C.
Sci Rep. 2016 May 6;6:25550
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.
Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker HW, Chalaris A.
J Leukoc Biol. 2016 May;99(5):749-60
Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts.
Malysheva K, de Rooij K, Lowik CW, Baeten DL, Rose-John S, Stoika R, Korchynskyi O.
Croat Med J. 2016 Apr 23;57(2):89-98
Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.
Birner P, Heider S, Petzelbauer P, Wolf P, Kornauth C, Kuroll M, Merkel O, Steiner G, Kishimoto T, Rose-John S, Soleiman A, Moriggl R, Kenner L.
Exp Dermatol. 2016 Apr;25(4):305-10
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D.
Oncotarget. 2016 Apr 5;7(14):17431-41.
Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation.
Marmary Y, Adar R, Gaska S, Wygoda A, Maly A, Cohen J, Eliashar R, Mizrachi L, Orfaig-Geva C, Baum BJ, Rose-John S, Galun E, Axelrod JH.
Cancer Res. 2016 Mar 1;76(5):1170-80
Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA.
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3006-11
KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.
Rosean TR, Holman CJ, Tompkins VS, Jing X, Krasowski MD, Rose-John S, Janz S.
Blood Cancer J. 2016 Feb 26;6:e398
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C.
Cell Rep. 2016 Feb 23;14(7):1761-1773
A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.
Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C.
Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6
IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.
Brooks GD, McLeod L, Alhayyani S, Miller A, Russell PA, Ferlin W, Rose-John S, Ruwanpura S, Jenkins BJ.
Cancer Res. 2016 Feb 15;76(4):866-76
IL-6 Trans-Signaling Drives Murine Crescentic GN.
Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J
J Am Soc Nephrol. 2016 Jan;27(1):132-42
2015
Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells.
Holmer R, Wätzig GH, Tiwari S, Rose-John S, Kalthoff H.
BMC Cancer. 2015 Dec 16;15:975.
RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity.
Mittelberger F, Meyer C, Waetzig GH, Zacharias M, Valentini E, Svergun DI, Berg K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U.
RNA Biol. 2015;12(9):1043-53
Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles.
Schumacher N, Meyer D, Mauermann A, von der Heyde J, Wolf J, Schwarz J, Knittler K, Murphy G, Michalek M, Garbers C, Bartsch JW, Guo S, Schacher B, Eickholz P, Chalaris A, Rose-John S, Rabe B.
J Biol Chem. 2015 Oct 23;290(43):26059-71
Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
Grill M, Syme TE, Noçon AL, Lu AZ, Hancock D, Rose-John S, Campbell IL
Glia. 2015 Oct;63(10):1738-52
Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation.
Ullah MA, Revez JA, Loh Z, Simpson J, Zhang V, Bain L, Varelias A, Rose-John S, Blumenthal A, Smyth MJ, Hill GR, Sukkar MB, Ferreira MA, Phipps S
J Allergy Clin Immunol. 2015 Oct;136(4):1065-73
Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer.
Goumas FA, Holmer R, Egberts JH, Gontarewicz A, Heneweer C, Geisen U, Hauser C, Mende MM, Legler K, Röcken C, Becker T, Waetzig GH, Rose-John S, Kalthoff H
Int J Cancer. 2015 Sep 1;137(5):1035-46
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.
Kreins AY, Ciancanelli MJ, Okada S, Kong XF, Ramírez-Alejo N, Kilic SS, El Baghdadi J, Nonoyama S, Mahdaviani SA, Ailal F, Bousfiha A, Mansouri D, Nievas E, Ma CS, Rao G, Bernasconi A, Sun Kuehn H, Niemela J, Stoddard J, Deveau P, Cobat A, El Azbaoui S, Sabri A, Lim CK, Sundin M, Avery DT, Halwani R, Grant AV, Boisson B, Bogunovic D, Itan Y, Moncada-Velez M, Martinez-Barricarte R, Migaud M, Deswarte C, Alsina L, Kotlarz D, Klein C, Muller-Fleckenstein I, Fleckenstein B, Cormier-Daire V, Rose-John S, Picard C, Hammarstrom L, Puel A, Al-Muhsen S, Abel L, Chaussabel D, Rosenzweig SD, Minegishi Y, Tangye SG, Bustamante J, Casanova JL, Boisson-Dupuis S.
J Exp Med. 2015 Sep 21;212(10):1641-62
STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.
Nat Commun. 2015 Jul 22;6:7736
A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.
Hong SS, Choi JH, Lee SY, Park YH, Park KY, Lee JY, Kim J, Gajulapati V, Goo JI, Singh S, Lee K, Kim YK, Im SH, Ahn SH, Rose-John S, Heo TH, Choi Y.
J Immunol. 2015 Jul 1;195(1):237-45
Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RA, Panzer U, Steinmetz OM.
J Am Soc Nephrol. 2015 Jul;26(7):1597-607
Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages.
Beyer C, Huang J, Beer J, Zhang Y, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Maier C, Munoz L, Krönke G, Uderhardt S, Distler O, Jones S, Rose-John S, Oravecz T, Schett G, Distler JH
Ann Rheum Dis. 2015 Jun;74(6):1317-24
Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat.
Garcia-Oscos F, Peña D, Housini M, Cheng D, Lopez D, Cuevas-Olguin R, Saderi N, Salgado Delgado R, Galindo Charles L, Salgado Burgos H, Rose-John S, Flores G, Kilgard MP, Atzori M
J Neurosci Res. 2015 Jun;93(6):859-65
Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma.
Mackiewicz J, Karczewska-Dzionk A, Laciak M, Kapcinska M, Wiznerowicz M, Burzykowski T, Zakowska M, Rose-John S, Mackiewicz A.
Medicine (Baltimore). 2015 May;94(21):e853
IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans.
Müller N, Schulte DM, Türk K, Freitag-Wolf S, Hampe J, Zeuner R, Schröder JO, Gouni-Berthold I, Berthold HK, Krone W, Rose-John S, Schreiber S, Laudes M
J Lipid Res. 2015 May;56(5):1034-42
Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.
van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM
Am J Pathol. 2015 Apr;185(4):1145-55
Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.
Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, EstevezE, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S,Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A,Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA
Cell Metab. 2015 Mar 3;21(3):403-16
Pharmaceutical relevant cytokine receptors: lessons from the first drafts of the human proteome.
Garbers C, Rose-John S
J Proteome Res. 2015 Feb 6;14(2):1330-2
ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis.
Caolo V, Swennen G, Chalaris A, Wagenaar A, Verbruggen S, Rose-John S, Molin DG, Vooijs M, Post MJ
Angiogenesis. 2015 Jan;18(1):13-22
Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M.
Hsu MP, Frausto R, Rose-John S, Campbell IL
Glia. 2015 Jan;63(1):132-41
Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex.
Garcia-Oscos F, Peña D, Housini M, Cheng D, Lopez D, Borland MS, Salgado-Delgado R, Salgado H, D'Mello S, Kilgard MP, Rose-John S, Atzori M
Brain Behav Immun. 2015 Jan;43:149-58
2014
Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease.
Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reißig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Münzel T
Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2658-68
GP130 activation induces myeloma and collaborates with MYC.
Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U
J Clin Invest. 2014 Dec;124(12):5263-74
Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6.
Reif A, Siebenhaar S, Tröster A, Schmälzlein M, Lechner C, Velisetty P, Gottwald K, Pöhner C, Boos I, Schubert V, Rose-John S, Unverzagt C
Angew Chem Int Ed Engl. 2014 Nov 3;53(45):12125-31
Mycobacterium simiae infection in two unrelated patients with different forms of inherited IFN-γR2 deficiency.
Martínez-Barricarte R, Megged O, Stepensky P, Casimir P, Moncada-Velez M, Averbuch D, Assous MV, Abuzaitoun O, Kong XF, Pedergnana V, Deswarte C, Migaud M, Rose-John S, Itan Y, Boisson B, Belkadi A, Conti F, Abel L, Vogt G, Boisson-Dupuis S, Casanova JL, Bustamante J
J Clin Immunol. 2014 Nov;34(8):904-9
Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.
Effenberger T, von der Heyde J, Bartsch K, Garbers C, Schulze-Osthoff K, Chalaris A, Murphy G, Rose-John S, Rabe B
FASEB J. 2014 Nov;28(11):4847-56
Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.
Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C
PLoS One. 2014 Sep 26;9(9):e107990
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.
Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF
Cell Metab. 2014 Sep 2;20(3):433-47
Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.
Quarta S, Baeumer BE, Scherbakov N, Andratsch M, Rose-John S, Dechant G, Bandtlow CE, Kress M
J Neurosci. 2014 Sep 24;34(39):13222-33
The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.
Marczynska J, Ozga A, Wlodarczyk A, Majchrzak-Gorecka M, Kulig P, Banas M, Michalczyk-Wetula D, Majewski P, Hutloff A, Schwarz J, Chalaris A, Scheller J, Rose-John S, Cichy J
J Immunol. 2014 Sep 15;193(6):2753-63
IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function.
Böttcher JP, Schanz O, Garbers C, Zaremba A, Hegenbarth S, Kurts C, Beyer M, Schultze JL, Kastenmüller W, Rose-John S, Knolle PA
Cell Rep. 2014 Sep 11;8(5):1318-27
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J
Biochim Biophys Acta. 2014 Sep;1842(9):1485-94
Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.
Chow SZ, Speck M, Yoganathan P, Nackiewicz D, Hansen AM, Ladefoged M, Rabe B, Rose-John S, Voshol PJ, Lynn FC, Herrera PL, Müller W, Ellingsgaard H, Ehses JA
Diabetes. 2014 Sep;63(9):2984-95
Dendritic cell development requires histone deacetylase activity.
Chauvistré H, Küstermann C, Rehage N, Klisch T, Mitzka S, Felker P, Rose-John S, Zenke M, Seré KM
Eur J Immunol. 2014 Aug;44(8):2478-88
RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.
Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N
Cardiovasc Res. 2014 Jul 15;103(2):206-16
Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.
Schlecker E, Fiegler N, Arnold A, Altevogt P, Rose-John S, Moldenhauer G, Sucker A, Paschen A, von Strandmann EP, Textor S, Cerwenka A
Cancer Res. 2014 Jul 1;74(13):3429-40
The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).
Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J
J Biol Chem. 2014 Jun 27;289(26):18442-50
A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor.
Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J
J Biol Chem. 2014 Jun 6;289(23):16336-48
Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.
Aparicio-Siegmund S, Sommer J, Monhasery N, Schwanbeck R, Keil E, Finkenstädt D, Pfeffer K, Rose-John S, Scheller J, Garbers C
Oncotarget. 2014 Apr 30;5(8):2131-48
IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions.
Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A
J Invest Dermatol. 2014 Mar;134(3):728-735
Stabilized Interleukin-6 receptor binding RNA aptamers.
Meyer C, Berg K, Eydeler-Haeder K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U
RNA Biol. 2014;11(1):57-65
Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.
Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J
Biochim Biophys Acta. 2014 Feb;1843(2):275-87
Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.
Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J
J Neurosci. 2014 Feb 12;34(7):2503-13
Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.
Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A
J Biol Chem. 2014 Jan 31;289(5):3080-93
Oncogenic deletion mutants of gp130 signal from intracellular compartments.
Schmidt-Arras D, Müller M, Stevanovic M, Horn S, Schütt A, Bergmann J, Wilkens R, Lickert A, Rose-John S
J Cell Sci. 2014 Jan 15;127(Pt 2):341-53
"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells.
Trilling M, Le VT, Rashidi-Alavijeh J, Katschinski B, Scheller J, Rose-John S, Androsiac GE, Jonjic S, Poli V, Pfeffer K, Hengel H
J Immunol. 2014 Jan 1;192(1):447-58
T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
Dewitz C, Möller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S
FEBS J. 2014 Jan;281(1):157-74
2013
ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice.
Vidal PM, Lemmens E, Avila A, Vangansewinkel T, Chalaris A, Rose-John S, Hendrix S
Cell Death Dis. 2013 Dec 12;4:e954
Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A
Biochim Biophys Acta. 2013 Dec;1833(12):3355-3367
Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
J Immunol. 2013 Dec 1;191(11):5574-82
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3).
Möller-Hackbarth K, Dewitz C, Schweigert O, Trad A, Garbers C, Rose-John S, Scheller J
J Biol Chem. 2013 Nov 29;288(48):34529-44
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).
Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J
Cell Cycle. 2013 Nov 1;12(21):3421-32
Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions.
Martin P, Palmer G, Vigne S, Lamacchia C, Rodriguez E, Talabot-Ayer D, Rose-John S, Chalaris A, Gabay C
J Leukoc Biol. 2013 Oct;94(4):791-802
Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice.
Tsantikos E, Maxwell MJ, Putoczki T, Ernst M, Rose-John S, Tarlinton DM, Hibbs ML.
Arthritis Rheum. 2013 Oct;65(10):2691-702
Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets.
Marino M, Scuderi F, Ponte E, Maiuri MT, De Cristofaro R, Provenzano C, Rose-John S, Cittadini A, Bartoccioni E
J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):841-52
Trp53 deficiency protects against acute intestinal inflammation.
Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.
J Immunol. 2013 Jul 15;191(2):837-47
An analysis of the function and expression of D6 on lymphatic endothelial cells.
McKimmie CS, Singh MD, Hewit K, Lopez-Franco O, Le Brocq M, Rose-John S, Lee KM, Baker AH, Wheat R, Blackbourn DJ, Nibbs RJ, Graham GJ
Blood. 2013 May 2;121(18):3768-77
In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli.
Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, Shriki A, Klaus S, Rosen S, Rose-John S, Galun E, Axelrod JH, Heyman SN
Clin Exp Pharmacol Physiol. 2013 Apr;40(4):262-72
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H
J Clin Invest. 2013 Mar;123(3):1019-31
The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model.
Wei LH, Chou CH, Chen MW, Rose-John S, Kuo ML, Chen SU, Yang YS
J Clin Endocrinol Metab. 2013 Mar;98(3):E472-84
gp130 activation is regulated by D2-D3 interdomain connectivity.
Schütt A, Zacharias M, Schneider N, Horn S, Grötzinger J, Rose-John S, Schmidt-Arras D
Biochem J. 2013 Mar 15;450(3):487-96
Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice.
Braun O, Dewitz C, Möller-Hackbarth K, Scheller J, Schiffelholz T, Baier PC, Rose-John S (2013)
J Interferon Cytokine Res. 2013 May;33(5):254-60
ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.
Trad A, Hansen HP, Shomali M, Peipp M, Klausz K, Hedemann N, Yamamoto K, Mauermann A, Desel C, Lorenzen I, Lemke H, Rose-John S, Grötzinger J
Cancer Immunol Immunother. 2013 Mar;62(3):411-21
mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease.
Derer S, Till A, Haesler R, Sina C, Grabe N, Jung S, Nikolaus S, Kuehbacher T, Groetzinger J, Rose-John S, Rosenstiel PC, Schreiber S
Gut. 2013 Mar;62(3):376-86
d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers.
Magbanua E, Zivkovic T, Hansen B, Beschorner N, Meyer C, Lorenzen I, Grötzinger J, Hauber J, Torda AE, Mayer G, Rose-John S, Hahn U
RNA Biol. 2013 Feb;10(2):216-27
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.
Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, Hölscher C, Rose-John S, Grötzinger J, Lorenzen I, Scheller J
J Biol Chem. 2013 Feb 8;288(6):4346-54
Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction.
Samavedam UK, Kalies K, Scheller J, Sadeghi H, Gupta Y, Jonkman MF, Schmidt E, Westermann J, Zillikens D, Rose-John S, Ludwig RJ
J Autoimmun. 2013 Feb;40:74-85
IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.
Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, Engel DR, Scheller J, Rose-John S, Mittrücker HW
J Immunol. 2013 Jan 15;190(2):703-11
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C
Cell Mol Life Sci. 2013 Jan;70(2):309-33
2012
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.
Hofmann S, Vögtle T, Bender M, Rose-John S, Nieswandt B
J Thromb Haemost. 2012 Dec;10(12):2581-92
Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.
Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, Rose-John S, Scheller J, Thiery J, Kratzsch J.
PLoS One. 2012;7(4):e34787
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis.
Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grötzinger J, Rose-John S, Ehlers S, Hölscher C
Immunobiology. 2012 Oct;217(10):996-1004
Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing.
ElSharawy A, Warner J, Olson J, Forster M, Schilhabel MB, Link DR, Rose-John S, Schreiber S, Rosenstiel P, Brayer J, Franke A
BMC Genomics. 2012 Sep 20;13:500
Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis.
Gerlach K, Daniel C, Lehr HA, Nikolaev A, Gerlach T, Atreya R, Rose-John S, Neurath MF, Weigmann B
Cancer Res. 2012 Sep 1;72(17):4340-50
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.
O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE
EMBO Mol Med. 2012 Sep;4(9):939-51
A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.
Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S
Biochem J. 2012 Jul 1;445(1):135-44
Dendritic cell lineage commitment is instructed by distinct cytokine signals.
Seré KM, Lin Q, Felker P, Rehage N, Klisch T, Ortseifer I, Hieronymus T, Rose-John S, Zenke M
Eur J Cell Biol. 2012 Jun-Jul;91(6-7):515-23
Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection.
Mackiewicz A, Mackiewicz J, Wysocki PJ, Wiznerowicz M, Kapcinska M, Laciak M, Rose-John S, Izycki D, Burzykowski T, Karczewska-Dzionk A
Expert Opin Investig Drugs. 2012 Jun;21(6):773-83. Erratum in: Expert Opin Investig Drugs. 2012 Jul;21(7):1065.
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.
Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, Janz S, Scheller J, Rose-John S
Blood. 2012 May 31;119(22):5173-81
The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.
Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J
FEBS Lett. 2012 Apr 24;586(8):1093-100
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J
J Biol Chem. 2012 Apr 20;287(17):13743-51
The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling.
Garcia-Oscos F, Salgado H, Hall S, Thomas F, Farmer GE, Bermeo J, Galindo LC, Ramirez RD, D'Mello S, Rose-John S, Atzori M
Biol Psychiatry. 2012 Apr 1;71(7):574-82
A designer hyper interleukin 11 (H11) is a biologically active cytokine.
Dams-Kozlowska H, Gryska K, Kwiatkowska-Borowczyk E, Izycki D, Rose-John S, Mackiewicz A
BMC Biotechnol. 2012 Mar 21;12:8
IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.
Traum D, Timothee P, Silver J, Rose-John S, Ernst M, LaRosa DF
J Leukoc Biol. 2012 Mar;91(3):427-35
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice.
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, Wollert KC, Seegert D, Rose-John S, Tietge UJ, Schieffer B, Grote K
Arterioscler Thromb Vasc Biol 2012 Feb;32(2):281-90
Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells.
Meyer C, Eydeler K, Magbanua E, Zivkovic T, Piganeau N, Lorenzen I, Grötzinger J, Mayer G, Rose-John S, Hahn U
RNA Biol. 2012 Jan;9(1):67-80
Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells.
Ding X, Lin Q, Ensenat-Waser R, Rose-John S, Zenke M
Stem Cells Dev. 2012 Jan;21(1):121-32
2011
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J
J Biol Chem 2011 Dec 16;286(50):42959-70
Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages.
Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, Hildner K, Hoffman A, Kiesslich R, Rink AD, Rau TT, Rose-John S, Kessler H, Schmidt J, Neurath MF
Gastroenterology. 2011 Dec;141(6):2026-38
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS
J Clin Invest. 2011 Oct;121(10):3846-59
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model.
Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH
Crit Care Med. 2011 Jun;39(6):1407-13
The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution.
Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):515-20
Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.
Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, Pappo O, Rose-John S, Galun E, Axelrod JH
J Hepatol. 2011 May;54(5):922-9
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.
Schiechl G, Bauer B, Fuss I, Lang SA, Moser C, Ruemmele P, Rose-John S, Neurath MF, Geissler EK, Schlitt HJ, Strober W, Fichtner-Feigl S
J Clin Invest. 2011 May;121(5):1692-708
Stat3/ Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H
Cancer Cell. 2011 Apr 12;19(4):456-69
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.
Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J
J Biol Chem. 2011 Apr 29;286(17):14804-11
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures.
Loppnow H, Zhang L, Buerke M, Lautenschläger M, Chen L, Frister A, Schlitt A, Luther T, Song N, Hofmann B, Rose-John S, Silber RE, Müller-Werdan U, Werdan K
J Cell Mol Med. 2011 Apr;15(4):994-1004
Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling.
Malchow S, Thaiss W, Jänner N, Waetzig GH, Gewiese-Rabsch J, Garbers C, Yamamoto K, Rose-John S, Scheller J
Biochim Biophys Acta. 2011 Mar;1812(3):290-301
Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis.
Loppnow H, Buerke M, Werdan K, Rose-John S
J Cell Mol Med. 2011 Mar;15(3):484-500
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ
J Immunol. 2011 Jan 15;186(2):1199-208
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer.
Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, Chang JS, Lai TC, Rose-John S, Kuo ML, Wei LH
Cancer Res. 2011 Jan 15;71(2):424-34
ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.
Conrad U, Plagmann I, Malchow S, Sack M, Floss DM, Kruglov AA, Nedospasov SA, Rose-John S, Scheller J
Plant Biotechnol J. 2011 Jan;9(1):22-31
2010
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S, Neurath MF(2010)
J Exp Med. 2010 Dec 20;207(13):2855-68
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA
Nat Immunol. 2010 Dec;11(12):1119-26
Role of IL-6 trans-signaling in CCl₄induced liver damage.
Gewiese-Rabsch J, Drucker C, Malchow S, Scheller J, Rose-John S
Biochim Biophys Acta. 2010 Nov;1802(11):1054-61
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.
Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R
Immunology. 2010 Nov;131(3):395-404
Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration.
Lam SP, Luk JM, Man K, Ng KT, Cheung CK, Rose-John S, Lo CM
Liver Transpl. 2010 Oct;16(10):1195-206
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B
Blood. 2010 Oct 28;116(17):3347-55
Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6
Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R
J Leukoc Biol. 2010 Sep;88(3):579-87
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J Exp Med. 2010 Aug 2;207(8):1617-24
Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.
Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J
Mol Biol Cell. 2010 Aug 1;21(15):2797-807. Erratum in: Mol Biol Cell. 2011 Jun;22(12):2132
Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.
McGreal EP, Davies PL, Powell W, Rose-John S, Spiller OB, Doull I, Jones SA, Kotecha S
Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):649-58
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
J Immunol. 2010 Feb 15;184(4):2130-9
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model.
Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, Scheller J, Rose-John S, Kado S, Takada T
J Immunol. 2010 Feb 1;184(3):1543-51
ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.
Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J
Biochim Biophys Acta. 2010 Feb;1803(2):234-45
N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D
J Biol Chem. 2010 Jan 15;285(3):1781-9
TNF- alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.
Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Böll B, Chalaris A, Simhadri VR, Wiegmann K, Krell HW, Rose-John S, Engert A, von Strandmann EP, Hansen HP
Leukemia. 2010 Jan;24(1):51-7
2009
Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, Tedjokusumo R, Esser K, Arzberger S, Kirschning CJ, Langenkamp A, Falk C, Büning H, Rose-John S, Protzer U
Hepatology. 2009 Dec;50(6):1773-82
G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation.
Sina C, Gavrilova O, Förster M, Till A, Derer S, Hildebrand F, Raabe B, Chalaris A, Scheller J, Rehmann A, Franke A, Ott S, Häsler R, Nikolaus S, Fölsch UR, Rose-John S, Jiang HP, Li J, Schreiber S, Rosenstiel P
J Immunol. 2009 Dec 1;183(11):7514-22
Interleukin-6 trans-signaling regulates glycogen consumption after D-galactosamine-induced liver damage.
Drucker C, Rabe B, Chalaris A, Schulz E, Scheller J, Rose-John S
J Interferon Cytokine Res. 2009 Nov;29(11):711-8
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M
J Neurosci. 2009 Oct 28;29(43):13473-83
Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep.
Benedict C, Scheller J, Rose-John S, Born J, Marshall L
FASEB J. 2009 Oct;23(10):3629-36
Transglutaminase- catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity.
Plagmann I, Chalaris A, Kruglov AA, Nedospasov S, Rosenstiel P, Rose-John S, Scheller J
J Biotechnol. 2009 Jun 15;142(2):170-8
IL-6-trans-signalling increases rapid-eye-movement sleep in rats.
May U, Schiffelholz T, Baier PC, Krueger JM, Rose-John S, Scheller J
Eur J Pharmacol. 2009 Jun 24;613(1-3):141-5
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
Baier PC, May U, Scheller J, Rose-John S, Schiffelholz T
Behav Brain Res. 2009 Jun 8;200(1):192-6
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.
Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J
J Virol. 2009 May;83(10):5117-26
Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production.
Chen L, Frister A, Wang S, Ludwig A, Behr H, Pippig S, Li B, Simm A, Hofmann B, Pilowski C, Koch S, Buerke M, Rose-John S, Werdan K, Loppnow H
Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H987-96
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M
Cancer Cell. 2009 Feb 3;15(2):103-13
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, Richards PJ, Slinn S, Ernst M, Jenkins BJ, Topley N, Rose-John S, Jones SA
J Immunol. 2009 Jan 1;182(1):613-22
Interleukin-6 and neural stem cells: more than gliogenesis.
Islam O, Gong X, Rose-John S, Heese K
Mol Biol Cell. 2009 Jan;20(1):188-99
2008
Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia.
von Bismarck P, Claass A, Schickor C, Krause MF, Rose-John S
Exp Lung Res. 2008 Dec;34(10):694-706
IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier.
Linker RA, Lühder F, Kallen KJ, Lee DH, Engelhardt B, Rose-John S, Gold R
J Neuroimmunol. 2008 Dec 15;205(1-2):64-72
Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130
Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J
J Biol Chem. 2008 Oct 3;283(40):27200-7
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C
J Cell Biol. 2008 Sep 8;182(5):993-1005
The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis.
Weigmann B, Lehr HA, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, Schmidt J, Galle PR, Rose-John S, Neurath MF
J Exp Med. 2008 Sep 1;205(9):2099-110
The transcription factor repertoire of Flt3+ hematopoietic stem cells.
Hieronymus T, Ruau D, Ober-Blöbaum J, Baek JH, Rolletschek A, Rose-John S, Wobus AM, Müller AM, Zenke M
Cells Tissues Organs. 2008;188(1-2):103-15
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
Mudter J, Amoussina L, Schenk M, Yu J, Brüstle A, Weigmann B, Atreya R, Wirtz S, Becker C, Hoffman A, Atreya I, Biesterfeld S, Galle PR, Lehr HA, Rose-John S, Mueller C, Lohoff M, Neurath MF
J Clin Invest. 2008 Jul;118(7):2415-26
IL-6/IL-6R axis plays a critical role in acute kidney injury.
Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH
J Am Soc Nephrol. 2008 Jun;19(6):1106-15
IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.
Marino M, Scuderi F, Provenzano C, Scheller J, Rose-John S, Bartoccioni E
J Neuroimmunol. 2008 May 30;196(1-2):41-8
Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.
Sudarman E, Bollati-Fogolín M, Hafner M, Müller W, Scheller J, Rose-John S, Eichler J
Chem Biol Drug Des. 2008 May;71(5):494-500
IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
Walker F, Zhang HH, Matthews V, Weinstock J, Nice EC, Ernst M, Rose-John S, Burgess AW
Blood. 2008 Apr 15;111(8):3978-85
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
Benrick A, Jirholt P, Wernstedt I, Gustafsson M, Scheller J, Eriksson AL, Borén J, Hedner T, Ohlsson C, Härd T, Rose-John S, Jansson JO
Regul Pept. 2008 Feb 7;146(1-3):189-96
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J
Blood. 2008 Feb 1;111(3):1021-8
2007
Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling.
Wei LH, Baumann H, Tracy E, Wang Y, Hutson A, Rose-John S, Henderson BW
Br J Cancer. 2007 Dec 3;97(11):1513-22
Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.
Koch M, May U, Kuhns S, Drechsler H, Adam N, Hattermann K, Wirtz S, Rose-John S, Scheller J
Biochem Biophys Res Commun. 2007 Dec 21;364(3):483-7
Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress.
Appenheimer MM, Girard RA, Chen Q, Wang WC, Bankert KC, Hardison J, Bain MD, Ridgley F, Sarcione EJ, Buitrago S, Kothlow S, Kaspers B, Robert J, Rose-John S, Baumann H, Evans SS
Eur J Immunol. 2007 Oct;37(10):2856-67
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.
Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones SA, Rose-John S, Scheller J
Blood. 2007 Sep 15;110(6):1748-55
Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells.
Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose-John S, Neurath MF, Becker C
J Immunol. 2007 Aug 15;179(4):2041-5
Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo.
Coles B, Fielding CA, Rose-John S, Scheller J, Jones SA, O'Donnell VB
Am J Pathol. 2007 Jul;171(1):315-25. Erratum in: Am J Pathol. 2007 Sep;171(3):1078
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.
Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF
Int Immunol. 2007 Jun;19(6):685-93
Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.
Yeoh GC, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB
Hepatology. 2007 Feb;45(2):486-94
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Eichenauer DA, Simhadri VL, von Strandmann EP, Ludwig A, Matthews V, Reiners KS, von Tresckow B, Saftig P, Rose-John S, Engert A, Hansen HP
Cancer Res. 2007 Jan 1;67(1):332-8
Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells.
Chattopadhyay S, Tracy E, Liang P, Robledo O, Rose-John S, Baumann H
J Biol Chem. 2007 Feb 2;282(5):3014-26